Jack R. Wands, MD, AGAF, AASLDF

Jack R. Wands, MD

Jeffrey and Kimberly Greenberg - Artemis and Martha Joukowsky Professor in Gastroenterology and Professor of Medical Science

Director, Division of Gastroenterology/Hepatology

Director, Liver Research Center

Phone: 401-444-5031

Email: [email protected]

Research Interests:

Research efforts include early diagnoses and therapy of alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH).  Other research investigations include identification and clarification of signaling pathways important in the pathogenesis of gastrointestinal malignancies that may provide new targets for early diagnosis and therapy using monoclonal antibody-based diagnostics and the development of cancer vaccines.  

Clinical Interests:

My clinical interests include acute and chronic liver disease, cirrhosis, and gastrointestinal malignancies.  I am particularly committed to hepatocellular carcinoma and alcohol induced liver disease and subsequent complications.

Selected Publications:

Comprehensive molecular and immunological characterization of hepatocellular carcinoma. Shimada S, Mogushi K, Akiyama Y, Furuyama T, Watanabe S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Tanabe M, Wands JR, Tanaka S.  EBioMedicine. 2018 Dec 28. pii: S2352-3964(18)30634-0. doi: 10.1016/j.ebiom.2018.12.058. [Epub ahead of print]

Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation.  Huang CK, Iwagami Y, Zou J, Casulli S, Lu S, Nagaoka K, Ji C, Ogawa K, Cao KY, Gao JS, Carlson RI, Wands JR.  Cancer Lett. 2018 Aug 10;429:1-10. doi: 10.1016/j.canlet.2018.04.041. Epub 2018 May 5.

Unusual Features of Sodium Taurocholate Cotransporting Polypeptide as a Hepatitis B Virus Receptor.  Li J, Zong L, Sureau C, Barker L, Wands JR, Tong S.  J Virol. 2016 Aug 26;90(18):8302-13. doi: 10.1128/JVI.01153-16. Print 2016 Sep 15.

Aspartate β-Hydroxylase expression promotes a malignant pancreatic cellular phenotype. Dong X, Lin Q, Aihara A, Li Y, Huang CK, Chung W, Tang Q, Chen X, Carlson R, Nadolny C, Gabriel G, Olsen M, Wands JR.  Oncotarget. 2015 Jan 20;6(2):1231-48.

A cell-surface β-hydroxylase is a biomarker and therapeutic target for hepatocellular carcinoma. Aihara A, Huang CK, Olsen MJ, Lin Q, Chung W, Tang Q, Dong X, Wands JR.  Hepatology. 2014 Oct;60(4):1302-13. doi: 10.1002/hep.27275. Epub 2014 Aug 25.