Steven Moss, MD
Steven Moss, MD
Professor of Medicine
Director - Brown University
Gastroenterology Fellowhip Training Program
E-mail: [email protected]
My research and clinical interests are focused on Helicobacter pylori and its association with and role in promoting gastric cancer. Research in my lab has investigated how H. pylori interacts with gastric epithelial cells to alter cell turnover and cause cell cycle dysregulation using co-culture systems and animal models with validation in clinical patient samples. More recent efforts have focused on H. pylori vaccine development to prevent infection, examination of local H. pylori eradication success rates, and exploration of molecular diagnostic testing of antibiotic resistance to guide therapy after treatment failure. We are currently recruiting patients with active H. pylori infection into a clinical study to compare molecular diagnostic testing of antibiotic resistance in gastric biopsy versus stool specimens
Resnick MB, Sabo E, Kim SS, Cho YS, Meitner P, Kim HK, Tavares R, Moss SF. Global analysis of the human gastric epithelial transcriptome altered by Helicobacter pylori eradication in vivo. Gut 2006; 55: 1717-1724.
Moise L, McMurry JA, Pappo J, Lee D-S, Moss SF, Martin WD, deGroot AS. Identification of genome-derived vaccine candidates conserved between human and mouse-adapted strains of H. pylori. Human Vaccines 2007 Dec 8;4(3)
Moss SF, Lee J-W, Sabo E, Rubin AK, Rommel J, Westley B, May FE, Gao J, Meitner P, Tavares R, Resnick MB. Decreased Gastrokine 1 and Trefoil Interacting Protein TFIZ1/GKN2 in Gastric Cancer: influence of Tumor Histology and Relationship to Prognosis. Clin Cancer Res 2008;14:4161-7.
Sabo E, Meitner P, Tavares R, Corless CL, Lauwers GY, Moss SF, Resnick MB. Expression analysis of Barrett’s esophagus-associated high grade dysplasia in laser capture microdissected archival tissue. Clin Cancer Res 2008; 14:6440-8.
Wen S, Moss SF. Pathogenesis of Helicobacter pylori virulence factors in Gastric Cancer. Cancer Letts 2009;282:1-8.