The Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital
Clinical Trials Program
|Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A-4 trial)
||Phase 3 secondary prevention multicenter trial aimed at treating older individuals at risk for developing Alzheimer’s disease dementia on the basis of having biomarker evidence of amyloid, by decreasing amyloid burden with solanezumab during the preclinical stage and hopefully delay cognitive decline over 3 years.|
|Aducanumab anti-amyloid antibody (EMERGE trial)||Phase 3, multicenter trial to to evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment in participants with early AD over 72 weeks.|
|BIIB092 anti-tau antibody (TANGO trial)
||Phase 2, multicenter trial to assess the efficacy of BIIB092 in slowing cognitive and functional impairment in particpants with mild cognitive impairment due to Alzheimer's disease or with mild Alzheimer's disease over 78 weeks.|
|ABBV-8E12 anti-tau antibody (AWARE trial)
||Phase 2, multicenter trial to assess the efficacy of ABBV-8E12 in slowing disease progression in people with early Alzheimer's disease and to assess long term efficacy for up to 96 weeks.
|Troriluzole (T2 PROTECT AD trial)||Phase 2, multicenter trial to determine if troriluzole can protect against, slow down, and potentially improve memory and thinking problems that increase as Alzheimer's disease progresses over 48 weeks.|
|Alzheimer's Disease NeuroImaging Initiative (ADNI-3)||This study is to develop improved brain imaging and biomarker methods in people with Alzheimer's disease, mild cognitive impairment, and normal elderly by acquiring high quality longitudinal data tha will be shared with the worl wide research community.
|Driving (Drive-Cam trial)||This study is to determine the efficacy of a video feedback intervention for reducing unsafe driving event frequency in older individuals with mild cognitive impairment and early Alzheimer’s disease compared to passive monitoring.|
|Yoga (Mind Body trial)||This study is to determine the preliminary efficacy of a yoga intervention for improving cognition, quality of life/emotional function, and daily living skills in individuals with mild cognitive impairment compared to the control, healthy living education.|
For more information about the clinical trials and research donation programs and how you can help, contact Dr. Lori Daiello at 444-3337 or email [email protected].