Musculoskeletal Tissue Engineering
Our laboratory focuses on the effects of biophysical and biochemical factors on chondrogenesis and the development of tissue-engineered cartilage and meniscus. Engineered musculoskeletal tissues can be used to restore cartilage function after traumatic cartilage injuries and may prevent diseases such as arthritis and osteoarthritis.
Our overall aim is to develop a transplantable biocomposite to restore function to cartilage of traumatized joints using tissue-engineering techniques. These techniques include the use of autologous adult stem cells, encapsulated drug delivery, biomaterial development and bioreactors.
Modulation of Tissue Development by Mechanical Loading
We designed a biaxial loading device for the investigation of the effects of dynamic biaxial mechanical loading (compressive and shear strain) on tissue-engineered cartilage. (Bilgen et al. 2012)
Stem Cell Chondrogenesis
We are working to optimize the chondrogenic ability of stem cells using co-cultures and growth factors. Synovial-derived stem cells could be a potential adult stem cell source for musculoskeletal tissue repair and regeneration. (Bilgen et al. 2009)
Decellularized Tissues as Scaffolds
Decellularization of cartilage is a potential alternative for chondral repair and regeneration. (Bautista et al. 2016)
Characterization of Collagen Organization
We have developed quantitative methods that are necessary to analyze the collagen fiber orientation in cartilage (References).