Nancy E. Lane, M.D. Professor and Director, UC Davis Center for Healthy Aging, Davis, CA

Kerby C. Oberg, M.D., Ph.D. Professor Department of Pathology and Human Anatomy, Loma Linda

Jack Dennerlein, Ph.D. Professor, Department of Physical Therapy, Movement & Rehabilitation Science, Northeastern University and Adjunct Professor of Ergonomics and Safety Department of Environmental Health, Harvard University.

Dr. Lane’s keynote lecture will focus on joint homeostasis, epidemiology, and the scope of thumb/hand arthritis in relation to large joint arthritis. Dr. Lane, MD is an internationally recognized scientist in the fields of both osteoarthritis and osteoporosis. Dr. Lane is an Endowed Professor of Medicine, Rheumatology, and Aging Research, Director for the Center for Musculoskeletal Health, Director of the K12 NIH Building Interdisciplinary Research Careers in Women’s Health (BIRCWH), and Principal Investigator of the NIH funded Program on Sex Differences in Musculoskeletal Diseases, Across the Lifespan at the University of California at Davis School of Medicine, where she has served for the past eight (8) years. Dr. Lane was President of the Board of the United States Bone and Joint Decade (2006-2008), co-led the International Bone and Joint Decade Conference in Washington DC (2010), was elected and serves on the council of the American Society of Bone and Mineral Research (2010-2013), and the Orthopedic Research Society. Dr. Lane is on the editorial boards of Nature Reviews Rheumatology, Rheumatology (Associate Editor), Seminars in Arthritis and Rheumatism (Associate Editor), Co-editor Arthritis and Rheumatism (2005-2010), and Journal of Rheumatology. Dr. Lane will speak on the specifics of thumb and hand osteoarthritis in the broader context of the pathophysiology of large joint arthritis.

Dr. Oberg’s keynote lecture will focus on the molecular basis of thumb development. Dr. Oberg is a Pediatric Pathologist whose practice emphasizes congenital anomalies and the molecular basis for malformations (molecular embryopathy). Using clinical disease as a starting point, his lab also studies the molecular mechanisms that control normal limb. Among his current projects is an exploration of the patterning mechanisms by which dorsal-ventral asymmetry is relayed to bones, joints, ligaments, and tendons of the forelimb via a transcription factor, Lmx1b. His interest in patterning includes its reactivation during regeneration using the forelimb as a model. A number of species (including humans) exhibit transient regeneration during development. During this transition, clues to molecules and mechanisms that promote regenerative wound healing are being exposed. Two key molecules currently under investigation are sonic hedgehog (Shh) and fibroblast growth factor (Fgf). Dr. Oberg’s group is exploring the mechanism and molecular pathways involved in Fgf’s up-regulation of Shh during limb development and regeneration.

Prof. Dennerlein’s keynote lecture will examine the effects of computer technology and tool design on upper extremity biomechanics. Within the ecological framework of computer-related musculoskeletal disorders, computer technology has a direct effect on the biomechanics of the user. Technology use can alter the loads on the upper extremity, increasing the risk of musculoskeletal disorders. However, as technology evolves to include novel mobile computing technologies, and as dynamic workstations emerge, such as sit-to-stand desks, new biomechanical loading scenarios emerge. Dr. Dennerlein’s work has continuously followed technology and evaluated effects of design on biomechanical loading and outcomes. His lab has demonstrated that device design does matter and that biomechanical loading can be reduced with innovative design. These findings have both influenced and validated the design of devices currently available in the market.  In addition, they have developed user and designer guidelines to optimize upper extremity biomechanical loads.