Publications

A complete list of Dr. Heffernan's publications can be found here.


Selected publications from 2011 - present:

Blakely, A. M., Heffernan, D. S., McPhillips, J., Cioffi, W. G., & Miner, T. J. (2014). Elevated C-reactive protein as a predictor of patient outcomes following palliative surgery. J Surg Oncol. [Epub ahead of print] 

Heffernan DS, Monaghan SF, Thakkar RK, Tran ML, Chung CS, Gregory SH, Cioffi WG, Ayala A. “A divergent response of innate regulatory T-cells to sepsis in humans: circulating invariant natural killer T-cells are preserved”. Hum. Imm.2014 75:277-282.

Lomas-Neira J, Venet F, Chung CS, Thakkar R, Heffernan D, Ayala A.“Neutrophil-Endothelial interactions mediate angiopoietin-2 associated pulmonary endothelial cell dysfunction in indirect ALI mice.” Am J Respir Cell Mol Biol 2014 50:193-200. PMID: 23980650.

Fox, E., Heffernan, D., Cioffi, W., and Reichner, J.S. Neutrophils from critically ill patients mediate profound loss of barrier integrity. Critical Care, 2013 17:226-232.

Heffernan DS, Monaghan SF, Thakkar RK, Tran ML, Chung CS, Gregory SH, Cioffi WG, Ayala A. “Inflammatory mechanisms in sepsis: elevated invariant natural killer T-cell numbers in mouse and their modulatory effect on macrophage function.” Shock 2013 Aug; 40(2):122-8. PMID: 23807244.

Duron VP, Monaghan SF, Connolly MD, Gregg SC, Stephen AH, Adams CA Jr, Cioffi WG, Heffernan DS. “Undiagnosed medical comorbidities in the uninsured: a significant predictor of mortality following trauma.” J Trauma Acute Care Surg 2012 Nov; 73(5):1093-8. PMID: 23117376.

Monaghan SF, Thakkar RK, Tran ML, Huang X, Cioffi WG, Ayala A, Heffernan DS. “PD-1 expression as a marker for immune and physiological dysfunction in the critically ill surgical patients.” Shock 2012 Aug;38(2):117-22. PMID: 22683728.

Shubin NJ, Chung CS, Heffernan DS, Irwin LR, Monaghan SF, Ayala A. “BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction.” J Leuko Biol 2012 Sep;92(3):593-603. PMID: 22459947. PMC3427605.

Heffernan DS, Monaghan SF, Thakkar RK, Machan JT, Cioffi WG, Ayala A. “Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern.” Crit Care 2012 Jan 20;16(1): R12. PMID: 22264310. PMC3396248.

Monaghan SF, Thakkar RK, Heffernan DS, Huang X, Chung CS, Lomas-Neira J, Cioffi WG, Ayala A. “Mechanisms of indirect acute lung injury: A novel role for the Co-inhibitory receptor Programmed Death-1 (PD-1). Ann Surg 2012 Jan; 255(1):158-164. PMID: 21997806. PMC3243770.

Heffernan DS, Dossett LA, Lightfoot MA, Fremont RD, Ware LB, Sawyer RG, May AK. “Gender and ARDS in critically injured adults: A prospective study.” J Trauma 2011: 71(4): 878-883. PMID: 21986736. PMC3201740.

Monaghan SF, Heffernan DS, Thakkar RK, Reinert, SE, Machan JT, Connolly MD, Gregg, SC, Kozloff MS, Adams CA, Cioffi WG. “The development of a Urinary Tract Infection is associated with increased mortality in trauma patients.” J Trauma. 2011; 71(6): 1569-1574. PMID: 21768897.

Heffernan DS. Vera RM, Monaghan SF, Thakkar RK, Kozloff MS, Connolly MD, Gregg SC, Machan JT, Harrington DT, Adams CA Jr, Cioffi WG. “Impact of socioethnic factors on outcomes following traumatic brain injury. J Trauma 2011; 70(3): 527-534. PMID: 21610339.

Thakkar RK, Chung CS, Chen Y, Monaghan SF, Lomas-Neira J, Heffernan DS, Cioffi WG, Ayala A. “Local tissue expression of the cell death ligand, FasL, plays a central role in the development of extra-pulmonary acute lung injury.” Shock 2011; 36(2): 138-143. PMID: 21451443. PMC3139824.