Publications

A complete list of Dr. Chung's publications can be found on Brown University's Faculty Profile Page.


(Selected publications from 2007 - present)

Huang, X., Chen, Y., Chung, C.S., Yuan, Z., Monaghan, S.F., Wang, F., Ayala, A. 2014. B7-H1, a novel mediator of the innate immune/pro-inflammatory response as well as a possible a novel myeloid cell prognostic biomarker in sepsis. J. Immunology 192:1091-9.(PMID: 24379123). (2014)

Bai, J.*, Tang, L.*, Lomas-Neira, J., Chen, Y., McLeish, K.R., Uriarte, S.M., Chung, C.S., Ayala, A. TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary-acute lung injury. Innate Immunity 19:(epub-ahead of press) (*J.B. and L.T. contributed equally as first authors to this work).(PMID: 24391146)(2014)

Heffernan, D., Monaghan, S., Chung, C.S., Cioffi, W., Gravenstein, S., Ayala, A. 2014. A divergent response of innate regulatory T-cells to sepsis in humans: circulating invariant natural killer T-cells are preserved. Human Immunology 74:( epub-ahead of press). (PMID: 24269692). (2014)

Ayala, A., Elphick, G.F., Kim, Y.S., Huang, X., Carreira-Rosario, A., Santos, S.C., Shubin, N.J., Chen, Y., Reichner, J.S., Chung, C.S. 2014. Sepsis induced potentiation of peritoneal macrophage migration is mitigated by PD-1 gene deficiency. J. Innate Immunity 5:(epub-ahead of press)(PMID: 24247196). (2014)

Lomas-Neira, J., Venet, F., Chung, C.S., Thakkar, R., Ayala, A. 2014. Neutrophil-endothelial Interactions mediate angiopoietin-2 associated pulmonary endothelial cell dysfunction in indirect acute lung injury. Amer. J. Resp. Cell. Mol. Biol. 50:193-200(PMID: 23980650). (2014)

Shubin, N.J., Monaghan, S.F., Heffernan, D.S., Chung, C.S., Irwin, L.R., Ayala, A. 2014. A new marker of septic immunosuppression? BTLA expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients. Crit. Care Forum 17:R276 (PMID: 24289156). (2014)

Hutchins, N.A., Wang, F., Wang, Y., Chung, C.S., Ayala, A. 2013. Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1. J. Leukocyte Biol. (epub-ahead of press) (PMID: 23766529). (2013)

Heffernan, D.S., Monaghan, S.F., Thakkar, R.K., Tran, M.L., Chung, C.S., Gregory, S.H., Cioffi, W.G., Ayala, A. 2013. Inflammatory mechanisms in sepsis: elevated invariant natural killer T-cell numbers in mouse and their modulatory effect on macrophage function. Shock 40:122-128. (PMID: 23807244). (2013)

Hutchins, N.A., Chung, C.S., Ayala, C.A., Borgerding, J.N., Ayala, A. 2013. Kupffer cells protect sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130. Amer. J. Pathol. 182: 742-54. (PMID: 23306157) (2013)

Lomas-Neira, J., Perl, M., Venet, F., Chung, C.S., Ayala, A. 2012. The Role and Source of TNF-α in Hemorrhage Induced Priming for Septic Lung Injury. Shock 37:611-20. (PMID: 22552013) (2012)

Shubin, N.J., Monaghan, S.F., Heffernan, D., Chung, C.S., Ayala, A. 2012. B and T Lymphocyte Attenuator (BTLA) and the role of lymphocytes in contributing to sepsis progression. J. Leukocyte Biol. 92:593-603. (PMID: 22459947) (2012)

Monaghan, S.F., Thakkar, R.K., Heffernan, D.S., Tran, M.L., Huang, X., Chung, C.S., Chen, Y., Lomas-Neira, J., Cioffi, W.G., Ayala, A. 2012. Mechanisms of indirect acute lung injury: a novel role for the co-inhibitory receptor, programmed death-1 (PD-1). Ann. Surg. 255:158-64. (PMID: 21997806) (2012)

McNeal, S.I., LeGolvan, M.P., Chung, C.S., Ayala, A. 2011. Dual functions of RIP1 in Fas induced hepatocyte death during sepsis. Shock 35:499-505. (PMID: 21263386). (2011)

Perl, M., Chung, C.S., Perl, U., Thakkar, R., Lomas-Neira, J., Ayala, A. 2010. Therapeutic accessibility of caspase mediated cell death as a key patho-mechanism in indirect acute lung injury. Crit. Care. Med. 39:1179-86. (PMID: 0154604). (2010)

Venet, F., Huang, X., Chung, C.S., Chen, Y., Ayala, A. 2010. Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice. Amer. J. Pathol. 176:764-73. (PMID: 20042672). (2010)

Chung, C.S., Venet, F., Chen, Y., Jones, L., Wilson, D., Ayala, C.A., Ayala, A. 2010. Deficiency of BID protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival. Shock 33:150-61. (PMID: 20023601). (2010)

Hu , C.K., Venet, F., Heffernan, D.S., Wang, Y.L., Horner, B., Huang, X., Chung, C.S., Gregory, S.H., Ayala, A. 2009. The Role of Hepatic Invariant (i)NKT Cells in Systemic/Local Inflammation and Mortality During Polymicrobial Septic Shock. Journal of Immunology 182(4):2467-75. (2009)

Huang, X., Venet, F., Wang, Y.L., Lepape, A., Yuan, Z., Wang, Y.L., Chen, Y., Swan, R., Kherouf, H., Monneret, G., Chung, C.S., Ayala, A. 2009. PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. P.N.A.S. USA 106:6303-6308. (2009)

Venet, F., Chung, C.S., Huang, X., Lomas-Neira, J., Chen, Y., Ayala, A. Lymphocytes in the development of lung inflammation: a role for regulatory cd4+ t cells in indirect pulmonary lung injury. J. Immunol. (In press). (2009)

Chung, C.S., Chen, Y., Grutkoski, P.S., Doughty, L., Ayala, A. 2007. SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis. Apoptosis 12:1143-1153. (2007)

Perl, M., Chung, C.S., Perl, U., Lomas-Neira, J., de Paepe, M., Cioffi, W.G., Ayala, A. 2007. Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury. Am J Respir Crit Care Med. 176(6):591-601. (2007)