Scientists capture ‘snapshot’ of bacterial stress-response

April 15, 2019
Protein color structure

A false-color structure of RssB (pink and cyan) — a protein that specifically recognizes a critical stress-response master regulator in bacteria and delivers it to the recycling machinery somewhat like a recycling truck — bound to IraD (green) — a factor that inhibits RssB activity. Both lobes of RssB, which are connected by a flexible linker (magenta) contact IraD in a “hug.”

Credit: Alexandra Deaconescu

Scientists have captured the first “snapshot” of two proteins involved in delivering a bacterial stress-response master regulator to the cell’s recycling machinery. The mechanism is critical to help bacteria survive nutrient deprivation and other stressful situations such as those encountered during the process of infecting a new host.