MPP Graduate Program Trainers

MPP Trainer Directory

Click on a faculty member's name to access their full profile. For a complete list of Biomed Faculty visit the Biomed Faculty Directory website.
Name Research Interest

Alfred Ayala
Professor of Surgery (Research)(Trauma) 

My research centers on understanding the pathophysiological effects of shock/tissue injury/sepsis that lead to immune dysfunction and subsequent multiple organ failure in the critically ill trauma patient (through animal modeling and collaborative clinical studies). 
Gilad Barnea
Associate Professor-Neuroscience
Our laboratory studies how the mammalian brain processes olfactory information and translates it into behavioral outputs.
David Berson 
Professor of Medical Science- Neuroscience  
My lab studies what the eye tells the brain. We explore the structure and function of ganglion cells, the retinal neurons that communicate directly with the brain. There are more than a dozen types of ganglion cells.
Wayne Bowen
MPPB Department Chair, Professor of Biology
We study sigma receptors, proteins that bind compounds with wide chemical diversity, including several classes of psychoactive drugs.  Sigma-1 receptors promote cell proliferation and survival, while sigma-2 receptors induce apoptotic cell death.  We are targeting sigma receptors for development of novel anti-cancer and neuroprotective agents.  We are elucidating signal transduction mechanisms mediating these cell viability changes and working with medicinal chemists to design and characterize selective sigma receptor ligands.
Gaurav Choudhary
Associate Professor of Medicine
The focus of our research is to evaluate the mechanisms underlying vascular dysfunction and cardiac dysfunction seen in pulmonary vascular diseases. The laboratory uses a variety of in vitro, ex vivo and in vivo approaches utilizing the preclinical models of pulmonary hypertension and emphysema.
Barry Connors
Professor of Medical Science- Neuroscience
I study the cellular physiology of the mammalian brain. Most of my work centers on the neocortex, which is responsible for thinking, remembering, processing sensory information, and controlling movement. 
Kareen Coulombe
Assistant Professor of Engineering
Our research mission is to re-engineer contractility in the heart using hiPSC-derived cardiomyocytes and working to develop mature engineered cardiac tissue that can integrate with the host heart through neovascularization and electromechanical coupling.
Eric Darling
Associate Professor of Medical Science
The Darling Lab focuses on understanding cellular heterogeneity and its influence on both fundamental and translational applications. Central to this, we explore the mechanical and biological characteristics of adult stem and non-stem cells as a means to improve tissue regeneration and cell-based therapies.
Michelle Dawson
Assistant Professor of Medical Science 
My research combines expertise in cell biophysics and cancer biology for quantitative analysis of the molecular and mechanical profiles of cells in tumor and tissue microenvironments. Research goals include: (1) developing novel therapies for metastatic cancer, (2) improving stem cell homing to tissues, and (3) using mechanics to guide in the development of tissue substitutes.
Suzanne de la Monte
Professor of Neurosurgery 
We study the roles of brain insulin deficiency and insulin resistance in neurodegeneration. Three diseases of major interest to us are: Alzheimer's, alcoholic neurodegeneration, and fetal alcohol syndrome.
Alexandra Deaconescu
Assistant Professor of Biology
Research in my laboratory focuses on the biochemical and biophysical underpinnings of the stress response and of DNA transactions essential for the maintenance of genomes and for controlling the flow of genetic information. Our approach combines biochemistry and biophysics with complementary structure determination methods (X-ray crystallography, small-angle X-ray scattering and electron microscopy) with the goal of elucidating the architecture, function, and regulation of protein and protein-nucleic acid complexes. Our work has direct relevance for biofilm formation and the development of novel antibiotics as well as neurodevelopment, cancer and accelerated aging.
Sarah Delaney 
Associate Professor of Chemistry 
The research in my laboratory aims to understand the biological consequences of DNA damage. Using the tools of chemistry and biology we probe the effects of DNA modification at the molecular level.
 Patrycja Dubielecka-Szczerba
Assistant Professor of Medicine (Research)
The goal of our research is to identify new targets for therapies aimed at eradicating drug resistant leukemic stem cells responsible for relapse.
Nicolas Fawzi
Assistant Professor of Medical Science

My laboratory studies the structure, dynamics, and molecular interactions of protein aggregates implicated in neurodegenerative disease. Using a combination of novel NMR spectroscopy approaches and atomistic simulation supplemented by biophysical and imaging methods, we determine high-resolution structures of these species and their toxic interactions with other macromolecules and membranes, as well as their interactions with potential therapeutic agents.

Philip Gruppuso
Professor of Pediatrics, Professor of Mol Biol/Cell Biol/Biochem (Research)

My laboratory focuses on the regulation of normal and abnormal somatic growth. We use liver as a model system, employing in vivo and in vitro models. We employ traditional cell biology and biochemical methods as well as proteomic and genomic approaches.

Elizabeth Harrington
Associate Dean for Graduate & Postdoctoral Studies, Professor Medicine (Research) 
My research focuses on characterizing intracellular signaling mechanisms which regulate endothelial cell functions and/or responses to environmental cues. Vascular injury has been implicated in the pathogenesis of disorders such as sepsis and acute respiratory distress syndrome (ARDS). Identification of molecules key in regulating endothelial cell functions may lead to therapeutic strategies for controlling vascular tissue damage and enhancing repair.
Anne Hart
Professor of Neuroscience
Anne Hart is a neurobiologist who uses genetic and molecular approaches in the small nematode C. elegans to understand the conserved mechanisms underlying neurodegenerative disease and nervous system function.
Edward Hawrot
Professor of Medical Science, Associate Dean of Biology  
We pursue biochemical and pharmacological studies aimed at understanding the fundamental structure-function relationship of nicotinic acetylcholine receptors (nAChRs). 
Alexander Jaworski 
Assistant Professor of Neuroscience
My laboratory studies the molecular and cellular mechanisms of brain wiring during embryonic development. To this end we employ a variety of experimental approaches, including molecular biology, biochemistry, embryology, and mouse
genetics.
Julie Kauer
Professor of Medical Science  
My laboratory focuses on understanding molecular mechanisms involved in synaptic plasticity and modulation of neuronal excitability using modern electrophysiological techniques in brain slices.
Karla Kaun
Assistant Professor of Neuroscience 
My lab uses the fruit fly, Drosophila melanogaster, to investigate the neural substrates of drug reward at the molecular and cellular level by mapping    areas in the fly brain that regulate alcohol reward, and uncovering genes and  pathways never-before implicated in memory of alcohol reward.
Gideon Koren
Professor of Medicine
Gideon Koren's research focuses on the regulation of expression voltage-gated potassium channels and mechanisms of sudden death. 
John Marshall 
Professor of Medical Science  
My lab is studying the trafficking and localization of glutamate receptors and calcium channels to synapses, and their modulation by protein kinases.
Edith Mathiowitz
Professor of Medical Science 
Research in our laboratory focuses on the polymer science-medicine interface. Areas of interest include development and modeling of novel drug delivery systems, particularly for the release of insulin and growth factors; etc. 
Ulrike Mende
Professor of Medicine 
Ulrike Mende is interested in the functional role of G proteins (GTP-binding proteins) and their regulators (Regulators of G protein Signaling) in the heart. 
Jeffrey Morgan
Professor of Medical Science and Engineering, Director of Biomedical Engineering 

The Morgan lab invented a new method to grow living cells in three dimensions (3D) and is using this technology to answer fundamental questions in high throughput phenotypic drug discovery, toxicity testing, drug transport and 3D tissue engineering. These areas are relevant to important medical needs including multi-drug resistance in cancer and the quest to find new and less toxic drugs while reducing the use of animals in research.

Eric Morrow
Associate Professor of Biology 
The Morrow lab investigates the genetic and molecular mechanisms underlying disorders of cognitive development, such as intellectual disability and autism.
Elena Oancea
Associate Professor of Medical Science 
The focus of my laboratory is in understanding signal transduction events using fluorescent microscopy in living cells. My lab is equipped with a state-of-the-art two-color TIRF microscope, which we will use to study UV-induced pigmentation in human skin and melanoma behavior. 
Rebecca Page
Professor of Biology
The focus of my research is to understand the molecular basis of MAP kinase regulation by its interaction with kinases, via scaffolding proteins, and phosphatases. 
Wolfgang Peti 
Professor of Medical Science  
The focus of my research group is to understand the molecular and functional basis of signaling processes essential to interfere with neurodegenerative and other neuronal diseases, cancer and diabetes.
Arthur Salomon
Associate Professor of Biology
My interests include: elucidation of signaling networks relevant to human disease and exploring perturbations in phosphorylation patterns induced by pharmacological agents.
Jason Sello
Associate Professor of Chemistry  
My research is inspired by naturally occurring antibiotics and the organisms from which they come. Streptomyces bacteria and their antibiotics are the primary subjects of my research.
Anita Shukla
Assistant Professor of Engineering
My research focuses on identifying and developing biomaterials solutions for critical unmet clinical needs in the areas of drug delivery and regenerative medicine.
Ian Wong
Assistant Professor of Engineering
Prof. Wong engineers new technologies to study cancer cell invasion, phenotypic plasticity and therapeutic resistance.
Anatoly Zhitkovich
Professor of Medical Science
Our main research efforts are directed at characterization of molecular mechanisms responsible for cell death and mutagenicity of DNA-reactive carcinogenic chemicals and anticancer drugs.
Peng Zhang
Assistant Professor of Medicine (Research)
My research focuses on  cardiac remodeling, with a particular interest in cardiac fibroblasts and their role and regulation in the normal and diseased heart. My laboratory uses both  in vitro and in vivo models along with gene manipulation approaches and analytical techniques.