In the Jaworski lab, we primarily study molecular mechanisms of neural circuit assembly during embryonic development. This research can advance our understanding of neurodevelopmental disease etiology and inform therapeutic approaches for the repair of damaged neuronal connections after physical injury or onset of neurodegenerative disease. More recently, we have also begun to study how neuronal connectivity is eroded in mouse models of amyotrophic lateral sclerosis, with the goal of identifying novel therapeutic targets for this devastating disease.