Alexandra Deaconescu

Assistant Professor of Molecular Biology, Cell Biology and Biochemistry


Research in my laboratory focuses on the biochemical and biophysical underpinnings of the stress response and of DNA transactions essential for the maintenance of genomes and for controlling the flow of genetic information. Our approach combines biochemistry and biophysics with complementary structure determination methods (X-ray crystallography, small-angle X-ray scattering and electron microscopy) with the goal of elucidating the architecture, function, and regulation of protein and protein-nucleic acid complexes. Our work has direct relevance for biofilm formation and the development of novel antibiotics as well as neurodevelopment, cancer and accelerated aging.