Wayne Bowen

Wayne Bowen
Upjohn Professor of Pharmacology
Professor of Biology & Chair of Molecular Pharmacology, Physiology and Biotechnology

Biography

We study sigma receptors, proteins that bind compounds with wide chemical diversity, including several classes of psychoactive drugs.  Sigma-1 receptors promote cell proliferation and survival, while sigma-2 receptors induce apoptotic cell death.  We are targeting sigma receptors for development of novel anti-cancer and neuroprotective agents.  We are elucidating signal transduction mechanisms mediating these cell viability changes and working with medicinal chemists to design and characterize selective sigma receptor ligands.