Cover Features and Publication Highlights
Dr. Jonathan Kurtis and team's paper on Schistosoma accepted to Infection and Immunity
Look for the research article, "Maternal infection with Schistosoma japonicum induces a pro-fibrotic response in neonates" by Emily McDonald, Ling Cheng, Blanca Jarilla, Marianne Sagliba, Annaliza Gonzal, Amabelle Amoylen, Remigio Olveda, Luz Acosta, David Baylink, Eric White, Jennifer Friedman, and Jonathan Kurtis, to be published in Infection and Immunity in the coming months.
Collaborative research by Brown Department of Pathology and Laboratory Medicine graces cover of January 2012 Issue of Chemical Research in Toxicology
Pathology and Laboratory Medicine researchers Drs. Sanchez, Jachak, Hurt, and Kane publish an article on interactions of graphene-family nanomaterials in Chemical Research in Toxicology, focusing on the biological mechanisms and responses with potential for increased function and safety in molecules, tissues, and organisms.
Click here to read the full article.
Dr. Anatoly Zhitkovich's research on chromium in drinking water featured on the October 2011 cover of Chemical Research in Toxicology
Dr. Zhitkovich addresses a growing public concern: Cr(VI), a carcinogen by inhalation, could potentially cause cancer in humans by ingestion. His studies show how environmental amounts of Cr(IV) in drinking water are not completely detoxified by the digestive tract, as previously expected. Thus establishing that naturally existing amounts can have a deleterious effect.
Find the full article here
The prevalent methods of evaluation of infertility rely upon physical examinations, as well as semen and hormone analyses; these measurements fail to explain the underlying causes of infertility. Dr. Boekelheide's lab uses an integrative genome-wide approach to identify CpG methylation profiles and mRNA alterations as genetic factors influencing low sperm motility and ultimately male fertility. The experimental evidence indicates the potential for improved therapeutic interventions based upon the relationship between motility and the molecular features of sperm.
Dr. Andres Matoso received the Stowell-Orbison Award, an award intended to recognize the best research work performed by a physician in training. The award, which is sponsored by the United States and Canadian Academy of Pathology (USCAP), recognized the work of Dr. Matoso and his collaborators working an inflammatory disorder in children (“eosinophilic esophagitis”). Although the disease is unknown cause, the research team, also including Drs. Mangray and Resnick in our department, identified a set of genes that are expressed in eosinophilic esophagitis, and extended the discovery to propose a protein expression profile that appears to be of diagnostic value.
CANICK TEAM IDENTIFIES NEW METHOD FOR DETECTING FETAL MALFORMATIONS
Dr. Jack Canick and his associates have developed a new method for the detection of fetal malformations using next generation sequencing. At this time, the most common methods to detect fetal malformations is using amniocentesis, using a needle to aspirate amniotic fluid from within the uterus. The new method developed by Canick and his associates, uses next generation sequencing to detect fragments of fetal DNA circulating in the maternal serum. During pregnancy, there are small amounts of fetal DNA circulating in the mother’s serum, and these DNA fragments can be detected and analyzed. In a series of articles, the team reports that this method allows early detection of fetal malformations in a high percentage of pregnancies.