Subject HIV-AIDS

Development and Pilot Testing of a Persuasive Health Communication Intervention for Emergency Department Patients Who Decline Rapid HIV/HCV Screening

Emergency departments (EDs) are an ideal venue to conduct screening for both HIV and HCV, given the high prevalence of HIV and HCV risk-taking behaviors among ED patients (e.g., sexual risk and drug use, particularly injection-drug use during the current opioid epidemic in the US); the known feasibility and acceptability of HIV and HCV screening in this setting; the proven yield of identifying those with undiagnosed infections in the ED; and the ability to link those with infections to subsequent care after the ED visit.

Real Time Phylogeny and Contact Tracing to Disrupt HIV Transmission

Real Time Phylogeny and Contact Tracing to Disrupt HIV Transmission Kantor, Rami MD NARRATIVE This proposal will evaluate the benefits of integrating different methods - contact tracing used to obtain social information from HIV-infected persons, and phylogenetics used to compare HIV between infected persons - to disrupt HIV transmission in Rhode Island.

HIV Treatment and Failure and Drug Resistance in Western Kenyan Children (RESPECT)

This study will generate new information on the development of treatment failure and drug resistance among a large, well-characterized cohort of HIV-infected children in western Kenya who receive common medications, using detailed, longitudinal, clinical, adherence, and drug concentration data. The proposed research is relevant to public health since such information is limited in the scientific literature, and withot it we cannot accurately assess treatment failure and drug resistance in HIV-infected children, which can lead to sickness and death.

Alcohol and HIV: Biobehavioral Interactions and Intervention

By increasing understanding of how excessive alcohol consumption and interventions to reduce excessive drinking can impact HIV-related health outcomes and sexual behavior that transmits HIV, this program project can contribute greatly to efforts to improve the health of those living with HIV and to reduce the spread of HIV.

Joseph Hogan Staff 1 Research Assistant i

Optimizing HIV Treatment Monitoring under Resource Constraints

Effective use of antiretroviral therapy is critical for managing and preventing the spread of HIV in the developing world. This proposal develops methods that make optimal use of diagnostic tests having limited availability to monitor the effectiveness of therapy and to prompt a change in regimen when it is warranted. Successful implementation will improve patient outcomes and help to prevent the spread of treatment-resistant strains of HIV.

HPV and Cervical Cancer in Kenyan Women with HIV/AIDS (HPV)

The interaction of human papillomavirus (HPV) with human immunodeficiency virus (HIV) represents one of the most "dangerous liaisons" for women in Sub-Saharan Africa. Understanding and addressing the modifiable co-factors described above could have profound implications on strategies to address cervical cancer in low to middle income countries beyond implementation of HPV 16/18-based vaccines (even if made affordable) and current screen and treat approaches for patients with abnormal Visual Inspection with Acetic Acid (VIA).

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