Novel Markers of Exposure and Pathways of Response to Chromium

Chromium (Cr) exposure through the drinking water and in occupational settings is a serious public health concern, inducing carcinogenesis in lung-derived cells and exposed populations. We propose an approach to investigate Chromium-gene interactions that is anchored in a major nuclear organelle (the nucleolus) and rDNA loci. The proposed work focuses on a novel pathway, an important exposure, and advances the NIH mission by generating knowledge, resources, and technologies that will advance both basic and public health studies of environmental triggers of human diseases.

Jean Wu Staff 1 Research Assistant i

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