Evidence-based Practice Center (EPC)

At the Center for Evidence Synthesis in Health we operate the Brown Evidence-based Practice Center (EPC) for the Effective Healthcare (EHC) Program of the Agency for Healthcare Research and Quality (AHRQ) of the U.S. Department of Health and Human Services (HHS). Ours is one of 13 EPCs currently sponsored by AHRQ.  

Our EPC develops comparative effectiveness reviews, evidence reports, and technology assessments on a spectrum of clinical and policy-oriented topics. Our reviews inform decisions of clinicians, patients, policy-makers, purchasers, and payers. We synthesize literature on clinical, behavioral, organizational, and financing topics, promotes improvements in health and healthcare and provides data for others to make coverage decisions develop quality measures, educational materials, and guidelines to set research agendas.

In addition, we manage and maintain the Systematic Review Data Repository (SRDR), an open collaborative web-based repository of systematic review data (AHRQ Contract No. HHSA 290-2007-10055-I & HHSA 290-2012-1200012-I ). This resource serves as both a central archive and data extraction tool, shared among and freely accessible to organizations producing systematic reviews worldwide. A suite of easy-to-use software tools with a web front-end enables researchers to seamlessly search for and incorporate previously deposited data into their own reviews, as well as contribute their own.  The SRDR™ was initially developed by Center for Evidence Synthesis in Health members who were at the then Tufts EPC.

We collaborate with Brown’s School of Public Health, the Alpert Medical School, affiliated hospitals, and a range of interdisciplinary scholars and departments (health services, policy & practice; biostatistics; computer science, etc.) throughout Brown University. We also work with other EPCs and AHRQ to advance the processes and methods of systematic reviews, their transparency, and their use in dissemination and translation of findings.

HISTORY
The Brown EPC was formed in 2012 from key individuals who moved to Brown from Tufts Medical Center in Boston. Joseph Lau established the Tufts EPC in 1997 as a charter member of 11 EPCs supported by AHRQ. The Brown EPC was formed within the new Center for Evidence-based Medicine in the School of Public Health under the Direction of Thomas Trikalinos and Joseph Lau.  

LEADERSHIP
Thomas Trikalinos, Director, Thomas_Trikalinos@brown.edu
Joseph Lau, CoDirector, Joseph_Lau@brown.edu
Issa Dahabreh, Associate Director, Issa_Dahabreh@brown.edu
Ethan Balk, Associate Director, ethan_balk@brown.edu
Christopher Schmid, Statistician, christopher_schmid@brown.edu
Constantine Gatsonis, Statistician, gatsonis@stat.brown.edu
Jenna Legault, Program Manager, jenna_legault@brown.edu

 RECENT EPC REPORTS

Transparency of Reporting Requirements: Tympanostomy Tubes. Springs S, Adam GP, Halladay H, Langberg V, Lin L, Balk EM, Trikalinos TA. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 September.

Transparency of Reporting Requirements: Omega-3 Fatty Acids and Cardiovascular Disease.Springs S, Adam GP, Halladay H, Langberg V, Lin L, Balk EM, Trikalinos TA. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 September.

Strategies for Improving the Lives of Women Aged 40 and Above Living With HIV/AIDS. Technical Brief No. 29. Adam GP, Di M, Cu-Uvin S, Halladay C, Smith BT, Trikalinos TA.  Rockville, MD: Agency for Healthcare Research and Quality; 2016 November.

Guidance for the Conduct and Reporting of Modeling and Simulation Studies in the Context of Health Technology Assessment. Methods Guide for Comparative Effectiveness Reviews. Dahabreh IJ, Trikalinos TA, Balk EM, Wong JB. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 September.

Omega-3 Fatty Acids and Cardiovascular Disease: An Updated Systematic ReviewBalk EM, Adam GP, Langberg V, Halladay C, Chung M, Lin L, Robertson S, Yip A, Steele D, Smith BT, Lau J, Lichtenstein AH, Trikalinos TA.  Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 July. 

Benefits and Harms of Routine Preoperative Testing: Comparative Effectiveness [Internet]. Balk EM, Earley A, Hadar N, Shah N, Trikalinos TA.  Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Jan. 

Oral Mechanical Bowel Preparation for Colorectal Surgery [Internet]. Dahabreh IJ, Steele DW, Shah N, Trikalinos TA.  Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Apr. []

Core Needle and Open Surgical Biopsy for Diagnosis of Breast Lesions: An Update to the 2009 Report [Internet]. Dahabreh IJ, Wieland LS, Adam GP, Halladay C, Lau J, Trikalinos TA.  Rockville (MD): Agency for Healthcare Research and Quality (US); 2014 Sep. 

Collaborations with other EPCs:

Systematic Reviews of Complex Multicomponent Health Care Interventions [Internet]. Guise JM, Chang C, Viswanathan M, Glick S, Treadwell J, Umscheid CA, Whitlock E, Fu R, Berliner E, Paynter R, Anderson J, Motu'apuaka P, Trikalinos TRockville (MD): Agency for Healthcare Research and Quality (US); 2014 Mar. PMID: 24696890

Agency for Healthcare Research and Quality Evidence-based Practice Center methods for systematically reviewing complex multicomponent health care interventions. Guise JM, Chang C, Viswanathan M, Glick S, Treadwell J, Umscheid CA, Whitlock E, Fu R, Berliner E, Paynter R, Anderson J, Motu'apuaka P, Trikalinos T.  J Clin Epidemiol. 2014 Nov;67 (11):1181-91. doi: 10.1016/j.jclinepi.2014.06.010. Epub 2014 Oct 17. PMID: 25438663

For a complete list of EPC projects, click here