Advanced Methods Journal Club

The Center for Evidence Synthesis in Health will host monthly advanced methods journal clubs to promote engagement and scholarship in evidence synthesis methods. These sessions are open to all members of the Brown University community. 

Material for journal club sessions can be found here.


Presenter and Title

Discussion Material

Thursday, September 21

12:00 pm- 1:00 pm

Room 375

George D. Papandonatos,  PhD          

Associate Professor of Biostatistics (Research)                                 

Lecture Title: Systematic Review and Meta Analyses on the FTO Genotype and Weight Loss

Description: FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.

Summary data was extracted from randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this review, using allele dose coding for genetic effects and a common set of covariates. Study level interactions were combined using random effect models. Metaregression and subgroup analysis were used to assess sources of study heterogeneity.



Andrew Zullo, PharmD, PhD    

Investigator in Health Services, Policy and Practice                                                                                                                                               

Lecture Title: TBA

Past events