Adaptive Intervention Strategies Trial for Strengthening Adherence to Antiretroviral HIV Treatment Among Youth

Multiple Principal Investigators
Matthew Mimiaga, ScD, MPH
Robert Garofalo, MD, MPH (Lurie Children's Hospital, Chicago)

Sponsor: National Institutes of Health (NIH)/National Institute of Nursing Research

Grant Number:
1R01NR017098-01

Evidence indicates that a significant and growing population of adolescents are acquiring and living with HIV in the U.S. According to the Centers for Disease Control and Prevention, an estimated >12,200 adolescents were diagnosed with HIV infection in 2010, a 22% increase since 2008. In 2010, adolescents made up only 17% of the US population, but accounted for 26% (12,200) of all new HIV infections (47,500) in the U.S. Although HIV can be managed with ongoing ART, exceptionally high levels of adherence are required. The purpose of this study is to test the efficacy of an integrated technology- and counseling-based antiretroviral therapy (ART) stepped care, adherence intervention ("Positive Steps") for HIV infected adolescents, ages 16 to 24. If successful, the stepped care intervention would be ready for translation studies to examine effectiveness testing and dissemination into "real-world" settings.