Jose Mercado-Ortiz


I am interested in understanding the mechanisms of interaction and RNA granule association of TDP-43, an intrinsically disordered protein associated with several neurodegenerative diseases including ALS, frontotemporal dementia and Alzheimer’s Disease. More specifically, I use biophysical and biochemical techniques like NMR spectroscopy to study how structure and disease mutations in TDP-43 affect phase separation and aggregation.