How can we understand how the brain works when it is healthy, and how it malfunctions in disease?
We need to observe both cellular and vascular dynamics, and their interactions. Professor Jonghwan Lee and his team are developing novel technologies that enable label-free, micrometer-resolution, in vivo imaging of various cellular and vascular dynamics in the cortex of animal disease models.
The Lee Lab is also applying the technologies to better understand and diagnose brain disorders, including ischemic stroke and Alzheimer’s disease. For example, the team characterizes how microcirculation varies with different stages of the ischemic stroke with unprecedented resolution and scale. They also trace microvascular and circulation parameters during development of Alzheimer’s disease to find novel early biomarkers.