COVID-19 clinical data is available for research through the new N3C analytics platform.
Data from more than 143,000 coronavirus-positive patients are now available to Rhode Island researchers through the new National COVID Cohort Collaborative (N3C) data platform.
In addition to the vast amounts of data available for coronavirus research, the N3C also aims to help scientists analyze these data to understand the disease and develop treatments. The N3C Data Enclave was officially launched in September 2020 and is funded by the National Center for Advancing Translational Sciences (NCATS).
Advance-CTR has joined a national IDeA-CTR effort, led by West Virginia CTSI, to contribute RI data to the platform. This work is currently underway.
The N3C enclave currently holds data related to roughly:
- 47 million visits,
- 61.9 million observations,
- 116.8 million procedures; and
- 694.8 million lab results.
The data originates from national health records of more than 1 million patients, 143.9K of whom were confirmed to have COVID-19. More than 60 organizations have agreed to contribute health records for the effort.
A complete overview of the N3C enclave is now available to researchers.
How to Request Access
Click the purple “Access the Enclave” button on the N3C website and follow instructions for first-time users. Your institution must have executed a Data Use Agreement prior to registering (in process or completed for Advance-CTR partner sites). Please use your institutional email address when registering. After you register for an account, access is granted within 48 business hours.
Three levels of data are available:
- Synthetic data or a safe data derivative,
- De-identified data; and
- Limited data.
If you request limited data, you will need IRB approval from your home institution and must provide documentation of human subject research protection training. If you have questions, follow the drop-down menu to the Support Desk page.
Data Use Requests
A Data Use Request (DUR) is an online application submitted by the researcher within the N3C Data Enclave that describes the scope and nature of the project and justifies the requested data access tier. Approval of the DUR by the Data Access Committee (DAC) is required before a researcher can access data within the enclave. (Approved DURs are valid for 1 year.) Please contact Advance-CTR for important information on this process at [email protected] .
Clinical Domain Teams
Domain teams are multidisciplinary research teams focusing on specific aspects of COVID-19 ranging from diabetes to pediatrics. These teams collaboratively submit data access requests to avoid duplication of efforts and to ensure appropriate expertise while answering questions about the pandemic. See the list of clinical domain teams.
- Generating sample data for pilot projects and grant proposals
- Training algorithms on a very large cohort of patients
- Opportunities to train junior researchers (the domain teams can offer support and a network for these investigators)
- Informatics and statistics opportunities for innovation and evaluation
- Opportunities for clinicians to investigate COVID-19 treatment patterns and disease progression
Complete these tutorials that are available from N3C
See more webinars and information sessions
- Read the JAMIA paper: "The National COVID Cohort Collaborative (N3C): Rationale, Design, Infrastructure, and Deployment"