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Welcome to the Coulombe Lab

Coulombe Lab 2016-2017Coulombe Lab 2016-2017

The focus of the Coulombe lab is to re-engineer contractility of the heart after injury or disease.  We use technologies in tissue engineering, biomaterials, muscle mechanics, and imaging to understand growth and maturation of human pluripotent stem cell-derived cardiomyocytes, cell-matrix interactions in 3D cardiac tissue, mechanical properties of engineered cardiac scaffolds and tissues, the process of vascularization, and whole heart contractility after implantation of engineered tissues.  

Our long-term goal is to develop a deep understanding of how to assemble functional myocardium in order to design regenerative therapies for the heart.