Photo: February 2021, via Zoom (Top (L-R): Dana Biechele-Speziale, Mary Tarantino, Paul Caffrey; Middle: Katelyn Rioux, Sarah Delaney, Giovannia Barbosa; Bottom: Treshaun Sutton, Selahaddin Gumus, Esther Webber)
Research in the Delaney laboratory aims to understand the biological consequences of DNA damage. Using the methods and tools of biochemistry, biophysics, and molecular biology we probe the effects of DNA damage from the molecular to the cellular level. We exploit our abilities to synthesize modified DNA nucleobases and study their properties within well-defined systems. We are particularly interested in the role of packaging of DNA into chromatin and how that packaging influences repair of DNA damage.