Publications from Delaney Group

41. Caffrey, P.J. and Delaney, S. Nucleosome core particles lacking H2B or H3 tails are altered structurally and have differential base excision repair fingerprints. Biochemistry 2021 60, 210-218. [Article]

40. Rioux, K.L. and Delaney, S. 1,N6-ethenoadenine: From molecular to biological consequences. Chem. Res. Toxicol. 2020 33, 2688-2698. [Article]

39. Caffrey P.J., Kher R., Bian K., Li D., Delaney S. Comparison of the base excision and direct reversal repair pathways for correcting 1,N6-ethenoadenine in strongly positioned nucleosome core particles. Chem. Res. Toxicol. 2020 33, 1888-1896. [Article]   **Honored as ACS Editors' Choice Article for May 1, 2020 [ACS Editors' Choice]**Featured on cover of July 2020 issue [Cover]

38. Caffrey, P.J. and Delaney, S. Chromatin and other obstacles to base excision repair: Potential roles in carcinogenesis. Mutagenesis 2020 35, 39-50. [Article]

37. Li, C. and Delaney, S. Challenges for base excision repair enzymes: Acquiring access to damaged DNA in chromatin. Book chapter in The Enzymes: DNA Repair 2019 45, 27-57. [Chapter]

36. Kennedy, E.E., Li, C., and Delaney, S. The global repair profile of human alkyladenine DNA glycosylase on nucleosomes reveals DNA packaging effects. ACS Chem. Biol. 2019 14, 1687-1692. [Article]

35. Li, C. and Delaney, S. Histone H2A variants enhance the initiation of base excision repair in nucleosomes. ACS Chem. Biol. 2019  14, 1041-1050. [Article] **Honored as ACS Editors' Choice Article for May 7, 2019. [ACS Editors' Choice]

34. Tarantino, M.E., Dow, B.J., Drohat, A.C., and Delaney, S.  Nucleosomes and the three glycosylases: High, medium, and low levels of excision by the uracil DNA glycosylase superfamily. DNA Repair. 201872, 56-63. [Article]

33. *Kennedy, E.E., *Caffrey, P.J. and Delaney, S. Initiating base excision repair in chromatin. DNA Repair 2018, 71, 87-92 . *Contributed equally. [Article]

32. *Bilotti, K., *Tarantino, M.E. and Delaney, S. Human oxoguanine glycosylase 1 removes solution accessible 8-oxo-7,8-dihydroguanine lesions from globally substituted nucleosomes except in the dyad region.
Biochemistry 2018, 57, 1436. [Article] *Contributed equally. Featured on Cover of March 2018 issue.

31. Bilotti, K., Kennedy, E.E., Li, C. and Delaney, S. Human OGG1 activity in nucleosomes is facilitated by transient unwrapping of DNA and is influenced by the local histone environment. DNA Repair2017, 59, 1. [Article]

30. Olmon, E.D. and Delaney, S. Differential ability of five DNA glycosylases to recognize and repair damage on nucleosomal DNA. ACS Chem. Biol. 2017, 12, 692. [Article] **Featured on Cover of March 17, 2017 issue. [Cover]

29. Huang, J. and Delaney, S. Unique length-dependent biophysical properties of repetitive DNA. J. Phys. Chem. B. 2016, 120, 4195. [Article]

28. Huang, J., Yennie, C. J., and Delaney, S. Klenow fragment discriminates against the incorporation of the hyperoxidized dGTP lesion spiroiminodihydantoin into DNA. Chem. Res. Toxicol. 2015, 28, 2325. [Article]

27. Tarantino, M.E., Bilotti, K., Huang, J., and Delaney, S. Rate-determining step of flap endonuclease 1 (FEN1) reflects a kinetic bias against long flaps and trinucleotide repeat sequences. J. Biol. Chem. 2015, 290, 21254. [Article]

26. Schermerhorn, K. M. and Delaney, S. A chemical and kinetic perspective on base excision repair of DNA. Acc. Chem. Res201447, 1238-1246. [Article]

25. Volle C. B. and Delaney S. AGG/CCT interruptions affect nucleosome formation and positioning of healthy-length CGG/CCG triplet repeats. BMC Biochemistry. 201314, 1-12. [Article]

24. Schermerhorn, K. M. and Delaney, S. Transient-state kinetics of apurinic/apyrimidinic (AP) endonuclease 1 acting on an authentic AP site and commonly-used substrate analogs: The effect of diverse metal ions and base 
mismatches. Biochemistry. 201352, 7669-7677. [Article]

23. Volle, C. B. and Delaney, S. CAG/CTG repeats alter affinity for the histone core and positioning of DNA in the nucleosome. Biochemistry201251, 9814-9825. [Article]

22. Yennie, C. J. and Delaney, S. Thermodynamic consequences of the hyperoxidized guanine lesion guanidinohydantoin in duplex DNA. Chem. Res. Toxicol. 201225, 1732-1739. [Article]

21. Delaney, S., Jarem, D. A., Volle, C. B., and Yennie, C. J. Chemical and biological consequences of oxidatively damaged guanine in DNAFree Rad. Res201246, 420-441. [Article]

20. Volle, C. B., Jarem, D. A., and Delaney, S.Trinucleotide repeat DNA alters structure to minimize the thermodynamic impact of 8-oxo-7,8-dihydroguanine. Biochemistry 201251, 52-62. [Article]

19. Jarem, D. A. and Delaney, S. Premutation huntingtin allele adopts a non-B conformation and contains a hot spot for DNA damage. Biochem. Biophys. Res. Comm2011416, 146-152. [Article]

18. Avila Figueroa, A.; Cattie, D. J.; Delaney, S. A small unstructured nucleic acid disrupts a trinucleotide repeat hairpin. Biochem. Biophys. Res. Comm2011413, 532-536. [Article]

17. Jarem, D. A.; Wilson, N. R.; Schermerhorn, K. M.; Delaney, S. Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with 
trinucleotide repeat expansion. DNA Repair 201110, 887-896. [Article]

16. Cooper, D. C., Yennie, C. J., Morin, J. B., Delaney, S. , and Suggs, J. W. Development of a DNA-damaging ferrocene amino acid. J. Organomet. Chem2011696, 3058-3061. [Article]

15. Avila Figueroa, A.; Cattie, D. J.; Delaney, S. Structure of even/odd trinucleotide repeat sequences modulates persistence of non-B conformations and conversion to duplex. Biochemistry 201150, 4441-4450. [Article]

14. Jarem, D. A.; Huckaby, L. V.; Delaney, S. AGG interruptions in (CGG)n DNA repeat tracts modulate the structure and thermodynamics of non-B conformations in vitroBiochemistry 201049, 6826-6837. [Article]

13. Avila Figueroa, A.; Delaney, S. Mechanistic studies of hairpin to duplex conversion for trinucleotide repeat sequences. J. Biol. Chem2010285, 14648-14657. [Article]

12. Jarem, D. A.; Wilson, N. R.; Delaney, S. Structure-dependent DNA damage and repair in a trinucleotide repeat sequence. Biochemistry 200948, 6655-6663. [Article]


Prior publications

11. Delaney, S.; Delaney, J. C.; Essigmann, J. M. Chemical-Biological Fingerprinting: Probing the properties of DNA lesions formed by peroxynitrite. Chem. Res. Toxicol. 200720, 1718-1729. [Article]

10. Neeley, W. L.; Delaney, S.; Alekseyev, Y. O.; Jarosz, D. F.; Delaney, J. C.; Walker, G. C.; Essigmann, J. M. DNA polymerase v allows bypass of toxic guanine oxidation products in vivoJ. Biol. Chem. 2007, 282
12741-12748. [Article]

9. Delaney, S.; Neeley, W. L.; Delaney, J. C.; Essigmann, J. M. The substrate specificity of MutY for hyperoxidized guanine lesions in vivoBiochemistry 200746, 1448-1455. [Article]

8. Delaney, S.; Yoo, J.; Stemp, E. D.; Barton, J. K. Charge equilibration between two distinct sites in double helical DNA. Proc. Natl. Acad. Sci. U. S. A. 2004101, 10511-10516. [Article]

7. Yoo, J.; Delaney, S.; Stemp, E. D.; Barton, J. K. Rapid radical formation by DNA charge transport through sequences lacking intervening guanines. J. Am. Chem. Soc. 2003125, 6640-6641. [Article]

6. Delaney, S.; Barton, J. K. Long-range DNA charge transport. J. Org. Chem. 200368, 6475-6483. [Article]

5. Delaney, S.; Barton, J. K. Charge transport in DNA duplex/quadruplex conjugates. Biochemistry 200342, 14159-14165. [Article]

4. Delaney, S.; Pascaly, M.; Bhattacharya, P. K.; Han, K.; Barton, J. K. Oxidative damage by ruthenium complexes containing the dipyridophenazine ligand or its derivatives:  A focus on intercalation. Inorg. Chem. 200241
1966-1974. [Article]

3. Choi, S.; Delaney, S.; Orbai, L.; Padgett, E. J.; Hakemian, A. S. A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA. Inorg. Chem. 200140, 5481-5482. [Article]

2. Choi, S.; Mahalingaiah, S.; Delaney, S.; Neale, N. R.; Masood, S. Substitution and reduction of platinum(IV) complexes by a nucleotide, guanosine 5'-monophosphate. Inorg. Chem. 199938, 1800-1805. [Article]

1. Choi, S.; Filotto, C.; Bisanzo, M.; Delaney, S.; Lagasee, D.; Whitworth, J. L.; Jusko, A.; Li, C. R.; Wood, N. A.; Willingham, J.; Schwenker, A.; Spaulding, K. Reduction and anticancer activity of platinum(IV) complexes. Inorg. 
 199837, 2500-2504. [Article]