Research Interests

The goal of the research group is to determine the structure and elucidate the molecular mechanisms of toxicity of aggregated and aggregation-prone states of proteins in degenerative diseases.

Current work focuses on:

  • RNA-binding proteins involved in ALS and frontotemporal dementias
  • Amyloid-β aggregation associated with Alzheimer's Disease
  • Transthyretin aggregation diseases

Recent and current funded projects include:

 

 

Finding the molecular switch of FUS protein self-assembly in neurodegeneration

NIGMS/NIH R01GM118530

The major goal of this project is to determine the structure of FUS along its assembly pathway in neurodegenerative disease.

Seeds of protein aggregation in inclusion body myositis

Center of Biomedical Research Excellence (COBRE) for Skeletal Health and Repair, Junior Investigator

The major goal of this pilot project is to develop a molecular picture of aggregation of hnRNP proteins in inclusion body myositis and myopathy

Structural characterization of soluble and neurotoxic aggregates of FUS

RI-IDeA/INBRE Research Proposal Development Project

The goal of this project is to develop the protocols for recombinant protein expression and purification of FUS, a human RNA binding protein that forms neuronal inclusions in ALS and frontotemporal dementia.

 

Protein Aggregation in Preeclampsia: New Mechanism for a Deadly Pregnancy Disease

DEANS Award 2015 EMERGING AREAS OF NEW SCIENCE, Brown University

The goals of this project are 1) to identify and quantify aggregated proteins in serum of patients with PE and 2) to evaluate the ability of these protein aggregates to cause features of PE in our “humanized” mouse model.