Our work in the Diane N. Weiss Center for Orthopaedic Trauma Research focuses on providing translational technologies aimed at preventing, treating, and minimizing the problems of infection related to orthopaedic trauma. Our approach emphasizes translational outcomes based on immediate clinical needs. Our general aim is focused on investigating the permitting factors relating to bacterial adherence and biofilm formation on clinically relevant surfaces, as well as means to more efficiently diagnose, treat, and prevent them.
Past and current studies focus on: the characterization of bacterial adherence on spinal implants of various compositions, preventative measures independent of antibiotics, in the form of biocompatible antimicrobial silver-doped Titanium Dioxide: Polydimethylsiloxane antimicrobial coating. Translation of antimicrobial coating on prosthetic liners, spinal implants, and catheters. Additionally, through the development of a Confocal Laser Scanning Microscopy and fluorescent conjugated antibodies, our team has developed an assay capable of directly visualizing and quantifying bacterial and fungal colonization and biofilm formation directly on explants, tissue, and synovial fluid before the patient leaves the operating room.