Ongoing Research

Translational Approaches to Orthopaedic Related Infections

Background on Orthopedic Infections

  • Annually, around two million fracture-fixation devices are inserted and although the rate of infection of closed fracture is low (1-2%), the rate of infection of traumatic open fractures is much higher (>30%)[1].
  • This increase in infection rate in traumatic open fractures is primarily due to invasion of bacteria during or after the traumatic event, but prior to surgery[1].
  • The most frequent microbe infection that occurs post-surgery for fracture fixation devices is Staphylococcus aureus (30% of infections), and although 27% of infections contain multiple different microbes, the second frequent species is coagulase-negative staphylococci (22%)[1].

Biofilm FormationBiofilm Formation