Neurological Dysfunction

Overview

This set of studies has focused on examining behavioral and  brain mechanisms in patients with neurological disorders, mostly motor dysfunction, particularly Parkinson's disease in current work and cerebellar dysfunction and deafferentation in earlier work.  The aim of these studies is to understand the 
behavioral and brain processes that go awry with neurological disorders while also aiming to reveal how the affected regions and circuits operate in healthy humans.  The outcome of the work also has implications for diagnosis and treatment, particularly from a rehabilitation perspective. 

Publications (If you download PDF versions of the publications, you have tacitly agreed to Fair Use policies.)

  • Bédard P. and J. N. Sanes  (2011)  Basal ganglia-dependent processes in short-term recall of visual-motor skills.  Experimental Brain Research, 209:385-393.  Pubmed citation | Download pdf
  • Bédard P. and J. N. Sanes  (2009)  On a basal ganglia role in learning and rehearsing visual-motor associations, NeuroImage, 47: 1701-1710.  Pubmed citation | Download pdf

Older Publications

  • Agostino, R., Sanes, J. N., and Hallett, M.  (1996)  Movement skill learning in Parkinson's disease.  Journal of the Neurological Sciences, 139: 218-226.  Pubmed citation Download pdf
  • Friedman, J. H. M. Epstein, J. N. Sanes, P. Lieberman, K. Cullen, C. Lindquist, M. Daamen  (1996)  Gamma knife pallidotomy in advanced Parkinson’s disease.  Annals of Neurology, 39:  535-538.  Pubmed citation | Download pdf
  • Labutta, R., R. B. Miles, J. N. Sanes, and M. Hallett  (1994)  Motor program memory storage in Parkinson's disease patients tested with a delayed response task.  Movement Disorders, 9:  218-222.  Pubmed citation Download pdf
  • Pullman, S. L., R. L. Watts, J. L. Juncos, and J. N. Sanes   (1990)  Movement amplitude choice reaction time performance in Parkinson's disease may be independent of dopaminergic status.  Journal of Neurology, Neurosurgery and Psychiatry, 53:  279-283.  Pubmed citation | Download pdf
  • Sanes, J. N., B. Dimitrov and M. Hallett  (1990)  Motor learning in patients with cerebellar dysfunction.  Brain  113: 103-120.  Pubmed citation
  • Pullman, S. L., R. L. Watts, J. L. Juncos, T. N. Chase and J. N. Sanes  (1988)  Dopaminergic effects on simple and choice reaction time performance in Parkinson's Disease.  Neurology  38:  249-254.  Pubmed citation
  • Sanes, J. N., K. -H. Mauritz, M. C. Dalakas and E. V. Evarts  (1985)  Motor control in humans with large-fiber sensory neuropathy.  Human Neurobiology  4:  101-114.  Pubmed citation 
  • Sanes, J. N.  (1985)  Information processing deficits in Parkinson's disease during movement.  Neuropsychologia  23: 381-392.  Pubmed citation
  • Sanes, J. N., K. -H. Mauritz, E. V. Evarts, M. C. Dalakas and A. Chu  (1984)  Motor deficits in patients with large-fiber sensory  neuropathy.  Proceedings of the National Academy of Science  81: 979-982.  Pubmed citation | Download pdf