Choudhary Research Overview

Choudhary lab 2022Choudhary lab 2022

Research Statement:

The focus of the research in my lab is to evaluate the mechanisms underlying vascular dysfunction and cardiac dysfunction seen in pulmonary vascular diseases.  The laboratory uses a variety of in vitro, ex vivo, and in vivo approaches utilizing the preclinical models of pulmonary hypertension and emphysema.  In clinical and epidemiological research, we are attempting to characterize the role and impact of cardiac dysfunction in settings of lung diseases, and study the epidemiology of pulmonary hypertension.

Research Focus Areas:

    1. Epidemiology of Pulmonary Hypertension
    2. Ion Channels in the Pulmonary Vasculature
    3. Right Ventricular Dysfunction
    4. Skeletel Muscle and Exercise Intolerance

      For a complete list of published work, click here.

      Current Funding:

      Funding Agency: National Institutes of Health, NHLBI R44HL166025 
      Role:  co-Principal Investigator
      Title:  Deep learning for algorithmic detection of pulmonary hypertension using a combined digital stethoscope and single-lead electrocardiogram
      Funding Period: 9/15/2022-8/31/2025 
      Funding Agency: National Institutes of Health, NHLBI R01 HL148727
      Role:  Principal Investigator
      Title:  Role of Endothelial Anoactamin-1 In Pulmonary Arterial Hypertension 
      Funding Period: 07/01/2019 - 06/30/2023
      Funding Agency: Department of Veterans Affairs, PULM-004-18S
      Role: Principal Investigator
      Title: Role of Skeletal Muscle Mitochondrial Supercomplexes in Exercise Intolerance
      Funding Period: 07/01/2019 - 06/30/2023
      Funding Agency: National Institutes of Health, NIGMS, P20GM103652  
      Role:  Co-Principal Investigator
      Title:   Endothelial Injury and Repair: CardioPulmonary Vascular Biology COBRE 
      Funding period:  09/20/2013 - 05/31/2023

      Direct Costs:  $2,064,137 
      Funding Agency: Department of Defense, W81XWH-19-1-0763 (Savitz)
      Role: Co-Investigator
      Title: Impact of Open Burn Pit Exposure on Respiratory and Cardiovascular Health Among Military Veterans   
      Funding Period: 09/15/2019 – 09/14/2022
      Funding Agency: National Institutes of Health, NIGMS, U54 GM115677 (Rounds) 
      Role: Director, Pilot Projects Core, Co- Investigator 
      Title: Advance Clinical and Translational Research (Advance-CTR)   
      Funding Period: 08/10/2021-07/09/2026 
      PREVENTABLE- Pragmatic Evaluation of Events and Benefits of Lipid-lowering in Older Adults
      Sponsor: National Institute of Ageing
      Trial Period: 2021-
      Role: Site Principal Investigator