Pulmonary hypertension is a disease associated with increased morbidity and mortality in general population. Few studies have evaluated the epidemiology of pulmonary hypertension in community-based population. We are investigating the epidemiology of pulmonary hypertension in a community-based population and in the VA cohorts.
Cardiac Magnetic Resonance Relationships
Scatterplots with fitted lines and 95% confidence intervals (CIs) demonstrating a linear relationship between the pulmonary artery pulse wave velocity (PA PWV) and right ventricle extracellular volume fraction, and an inverse linear relationship between the pulmonary artery relative area change (RAC) and right ventricle extracellular volume fraction. (From: Am J Respir Crit Care Med. 2019 Sep 15;200(6):776-779.)
Recent Publications:
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Jankowich M, Maron BA, Choudhary G*. Pulmonary Artery Systolic Pressure on Echocardiogram: Filling the Gap in Current Guidelines. Lancet Respir Med. 2021 Oct;9(10):1185-1191.
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Lahm T, Hess E, Barón AE, Maddox TM, Plomondon ME, Choudhary G, Maron BA, Zamanian RT, Leary PJ. Renin-Angiotensin-Aldosterone System Inhibitor Use and Mortality in Pulmonary Hypertension: Insights from the Veterans Affairs CART Database. Chest. 2020 Oct 5;. doi: 10.1016/j.chest.2020.09.258. [Epub ahead of print] PubMed PMID: 33031831.
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Maron BA, Brittan EL, Hess E, Waldo SW, Barón AE, Huang S, Goldstein RH, Assad T, Wertheim BM, Alba GA, Leopold JA, Olschewski H, Galiè N, Simonneau G, Kovacs G, Tedford RJ, Humbert M, Choudhary G. Pulmonary vascular resistance and clinical outcomes in patients with pulmonary hypertension: a retrospective cohort study. Lancet Respir Med. 2020 Sep;8(9):873-884. doi: 10.1016/S2213-2600(20)30317-9. Epub 2020 Jul 27. PubMed PMID: 32730752.
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Lakshmanan S, Jankowich M, Wu WC, Blackshear C, Abbasi S, Choudhary G. Gender Differences in Risk Factors Associated With Pulmonary Artery Systolic Pressure, Heart Failure, and Mortality in Blacks: Jackson Heart Study. J Am Heart Assoc. 2020 Jan 7;9(1):e013034. doi: 10.1161/JAHA.119.013034. Epub 2020 Jan 4. PubMed PMID: 31902323; PubMed Central PMCID: PMC6988159.
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Imran H, Jankowich M, Choudhary G. Pulmonary Hypertension Post Liver-Kidney Transplant. R I Med J (2013). 2019 Nov 1;102(9):23-26. PubMed PMID: 31675782
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Ali HR, Kiernan MS, Choudhary G, Levine DJ, Sodha NR, Ehsan A, Yousefzai R. Right Ventricular Failure Post-Implantation of Left Ventricular Assist Device: Prevalence, Pathophysiology, and Predictors. ASAIO J. 2019 Oct 23;. doi: 10.1097/MAT.0000000000001088.
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Huston JH, Maron BA, French J, Huang S, Thayer T, Farber-Eger EH, Wells QS, Choudhary G, Hemnes AR, Brittain EL. Association of Mild Echocardiographic Pulmonary Hypertension With Mortality and Right Ventricular Function. JAMA Cardiol. 2019 Sep 18;. doi: 10.1001/jamacardio.2019.3345.
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Jankowich M, Abbasi SA, Vang A, Choudhary G. Right Ventricular Fibrosis Is Related to Pulmonary Artery Stiffness in Pulmonary Hypertension: A Cardiac Magnetic Resonance Imaging Study. Am J Respir Crit Care Med. 2019 Sep 15;200(6):776-779. doi: 10.1164/rccm.201903-0580LE.
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Koo P, Gjelsvik A, Choudhary G, Wu WC, Wang W, McCool FD, Eaton CB. Prospective Association of Physical Activity and Heart Failure Hospitalizations Among Black Adults With Normal Ejection Fraction: The Jackson Heart Study. J Am Heart Assoc. 2017 Sep 7;6(9).
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Opotowsky AR, Hess E, Maron BA, Brittain EL, Barón AE, Maddox TM, Alshawabkeh LI, Wertheim BM, Xu M, Assad TR, Rich JD, Choudhary G, Tedford RJ. Thermodilution vs Estimated Fick Cardiac Output Measurement in Clinical Practice: An Analysis of Mortality From the Veterans Affairs Clinical Assessment, Reporting, and Tracking (VA CART) Program and Vanderbilt University. JAMA Cardiol. 2017 Oct 1;2(10):1090-1099.
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Jankowich M, Wu WC, Choudhary G. Elevated plasma endothelin-1 levels are associated with pulmonary hypertension, mortality, and heart failure in African-Americans: The Jackson Heart Study. JAMA Cardiology. 2016 Jul 1;1(4):461-9.