Ion Channels in the Pulmonary Vasculature

Pulmonary arterial hypertension is associated with pulmonary vascular remodeling and endothelial dysfunction. We have been evaluating role of endothelial ion channels in mediating endothelial dysfunction, pulmonary vasoconstriction and pulmonary vascular remodeling. We are evaluating endothelial ion channels as potential therapeutic targets in pulmonary hypertension.

Ano1 in MitochondriaAno1 in Mitochondria

Ano1 is localized to the plasma membrane (white arrow) and intracellular compartments, including mitochondria (inset) in RLMVEC. Scale bars = 10 μm (From: Am. J. Respir. Cell Mol. Biol. November 3, 2017).

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