Exercise intolerance is frequently associated with pulmonary hypertension. Using preclinical models, we are investigating the mechanisms underlying skeletal muscle dysfunction in pulmonary hypertension with particular focus on mitochondrail metabolism.
- McCullough, D. J., Kue, N., Mancini, T., Vang, A., Clements, R. T., & Choudhary, G. (2020). EXPRESS: Endurance Exercise Training in Pulmonary Hypertension increases Skeletal Muscle Electron Transport Chain Supercomplex Assembly. Pulmonary Circulation. https://doi.org/10.1177/2045894020925762