Research Focus Areas:
My laboratory focuses on mechanisms of immune-mediate vascular remodeling by studying areas where macrophages direct the biologic processes of arteriogenesis, vascular calcification, and pulmonary arterial hypertension. The goal of the research in my lab is to define macrophage-dependent signaling mechanisms that modulate these processes in order to identify novel targets for the development of therapeutic strategies.
Funding Agency: Department of Veterans Affairs, VA-ORD CDA-2, 5IK2BX002527
Role: Principal Investigator
Title: Calcific Atherosclerosis is Mediated by Macrophage Adhesion Signalling
Funding Period: 7/01/2014-6/30/2017
Direct Costs: $250,000
Funding Agency: NIH NIGMS P20GM103652 (Rounds)
Role: Pilot Project PI
Title: Therapeutic Targeting of IL-1ß-based Mechanisms in Calcific Aortic Valve Disease
Funding Period: 6/01/2016-5/31/2017
Direct Costs: $1,978,405 (Morrison: $50,000)
Ceneri, N, Young, BD, Zhao, L, Coskun, S, Vasavada, H, Yarovinsky, TO, Ike, K, Pardi, R, Hirschi, K, Sadeghi, M, Bender, JR, Morrison, AR. Rac2 Regulates Calcification of Atherosclerotic Plaques By Modulating Macrophage IL-1β Expression. Arterioscler, Thromb, Vasc Biol. 2016 In press.
Bailey, B, Meadows, J, Morrison, AR. Imaging Atherosclerotic Plaque Calcification: Translating Biology. Curr Atheroscl Rep. 2016 August;18(8):51.
Morrison, AR, Yarovinsky, TO, Young, BD, Moraes, F, Ross, TD, Ceneri, N, Zhang, J, Zhuang, ZW, Sinusas, AJ, Pardi, R, Schwartz, MA, Simons, M, Bender, JR. Chemokine-coupled ß2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exper Med. 2014 Sept;211(10):1957-1968.
Morrison, AR, Sinusas, AJ. Advances in Radionucleotide Molecular Imaging in Myocardial Biology. J Nuc Cardiol. 2010 Jan-Feb;17(1): 116-134.
Morrison, AR, Sinusas, AJ. New Molecular Imaging Targets to Characterize Myocardial Biology. Cardiol Clin. 2009 May;27:329-344.
Heysell, SK, Thomas, TA, Morrison, AR, Barry, M. Salmonella panama and ARDS in a traveler taking a proton-pump inhibitor. J Travel Med. 2008 Nov-Dec;15(6): 460-463.
Morrison, AR, Moss, J, Evans, J, Merrithew, E, Lambright, D, Farrell, C, Greiner, D, Mordes, J, Rossini, A, Bortell, R. ART2, A T cell surface mono-ADP-ribosyltransferase, generates extracellular poly(ADP-ribose). J Biol Chem. 2006 May;281(44):33363-33372.
Moss, J, Chung, A, Morrison, AR, Zheng, X, Bortell, R. Substrate Specificity of Soluble and Membrane Associated ADP-Ribosyltransferase ART2.1. J Cell Biochem. 2006 Jul;98(4):851-860.