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Morrison Lab Overview

Research Focus Areas:

My laboratory focuses on mechanisms of immune-mediate vascular remodeling by studying areas where macrophages direct the biologic processes of arteriogenesis, vascular calcification, and pulmonary arterial hypertension.  The goal of the research in my lab is to define macrophage-dependent signaling mechanisms that modulate these processes in order to identify novel targets for the development of therapeutic strategies.

Current Funding:

Funding Agency:  Department of Veterans Affairs, VA-ORD CDA-2, 5IK2BX002527
Role:  Principal Investigator
Title:  Calcific Atherosclerosis is Mediated by Macrophage Adhesion Signalling
Funding Period: 7/01/2014-6/30/2017
Direct Costs:  $250,000
Funding Agency:  NIH NIGMS P20GM103652 (Rounds)
Role:  Pilot Project PI
Title:  Therapeutic Targeting of IL-1ß-based Mechanisms in Calcific Aortic Valve Disease
Funding Period: 6/01/2016-5/31/2017
Direct Costs:  $1,978,405 (Morrison:  $50,000)

Recent Publications:

  • Ceneri, N, Young, BD, Zhao, L, Coskun, S, Vasavada, H, Yarovinsky, TO, Ike, K, Pardi, R, Hirschi, K, Sadeghi, M, Bender, JR, Morrison, AR.  Rac2 Regulates Calcification of Atherosclerotic Plaques By Modulating Macrophage IL-1β Expression. Arterioscler, Thromb, Vasc Biol. 2016 In press.