Brown University SealBrown University

Rounds Lab Overview

Research Focus Areas:

Sharon Rounds is interested in mechanisms of lung vascular injury in conditions causing pulmonary hypertension and acute lung injury. Her work focuses on the way in which endothelial cells of the lung circulation are injured. Current research focuses on the role of small GTPase post-translational processing in modulation of lung vascular permeability and apoptosis; the effects of tobacco smoke exposure on lung vascular permeability and lung endothelial cell apoptosis; and the effects of adenosine on lung vascular permeability.

She is also interested in chronic obstructive pulmonary disease and factors that impair compliance with therapy. Other clinical research interests are pulmonary hypertension and combined pulmonary fibrosis and emphysema.

Current Funding:

Funding Agency:  NIH NHLBI T32HL134625 (Harrington, Bennett, Levy, & Rounds)
Role:  Co-PITitle:  Brown Respiratory Research Training Program
Funding period:  04/01/17-08/31/21
Direct Costs:  $498,064
Funding Agency:  NIH NIGMS, P20GM109035 (Rand)
Role:  Mentor Project 3
Title:  COBRE:Center for Computational Biology of Human Disease
Funding period:  06/01/2016-05/31/2021
Direct Costs:  $2,359,578
Funding Agency:  NIH NIGMS, U54 GM115677 (Padbury)
Role:  PI Pilot Project Program
Title:  Rhode Island Center for Clinical and Translational Science
Funding period:  07/01/16-03/31/21
Direct Costs:  $3,974,123

Funding Agency:  Department of Veterans Affairs, 1I01CX000908-01 (Goldstein)

Role:  Co-Principal Investigator
Title:  Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease 
Funding period:  04/01/13 - 03/31/19 
Direct Costs:  $150,000 (Rounds:  $50,000)
Funding Agency:  Department of Veterans Affairs, Merit Review, BX002622
Role:  Principal Investigator
Title:  Mechanisms of Cigarette Smoke-Induced Acute Lung Injury 
Funding period:  04/01/14 - 03/31/19
Direct Costs:  $200,000 
 Funding Agency: NIH NIGMS P20GM103652
 Role:  Principal Investigator
Title:  Endothelial Injury and Repair:  Cardiopulmonary Vascular Biology COBRE
Funding period:  09/20/13 - 05/31/18

Direct Costs:  $1,987,405 (Rounds:  $236,946)

Recent Publications: