Research Focus Areas:
Sharon Rounds is interested in mechanisms of lung vascular injury in conditions causing pulmonary hypertension and acute lung injury. Her work focuses on the way in which endothelial cells of the lung circulation are injured. Current research focuses on the role of small GTPase post-translational processing in modulation of lung vascular permeability and apoptosis; the effects of tobacco smoke exposure on lung vascular permeability and lung endothelial cell apoptosis; and the effects of adenosine on lung vascular permeability.
She is also interested in chronic obstructive pulmonary disease and factors that impair compliance with therapy. Other clinical research interests are pulmonary hypertension and combined pulmonary fibrosis and emphysema.
Current Funding:
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Funding Agency: NIH NHLBI T32HL134625 (Harrington, Bennett, Levy, & Rounds)
Role: Co-PITitle: Brown Respiratory Research Training Program
Funding period: 04/01/17-08/31/21
Direct Costs: $498,064
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Funding Agency: NIH NIGMS, P20GM109035 (Rand)
Role: Mentor Project 3
Title: COBRE:Center for Computational Biology of Human Disease
Funding period: 06/01/2016-05/31/2021
Direct Costs: $2,359,578
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Funding Agency: NIH NIGMS, U54 GM115677 (Padbury)
Role: PI Pilot Project Program
Title: Rhode Island Center for Clinical and Translational Science
Funding period: 07/01/16-03/31/21
Direct Costs: $3,974,123
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Funding Agency: Department of Veterans Affairs, 1I01CX000908-01 (Goldstein) Role: Co-Principal Investigator
Title: Tadalafil for Pulmonary Hypertension Associated with Chronic Lung Disease
Funding period: 04/01/13 - 03/31/19
Direct Costs: $150,000 (Rounds: $50,000)
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Funding Agency: Department of Veterans Affairs, Merit Review, BX002622
Role: Principal Investigator
Title: Mechanisms of Cigarette Smoke-Induced Acute Lung Injury
Funding period: 04/01/14 - 03/31/19
Direct Costs: $200,000
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Funding Agency: NIH NIGMS P20GM103652
Role: Principal Investigator
Title: Endothelial Injury and Repair: Cardiopulmonary Vascular Biology COBRE
Funding period: 09/20/13 - 05/31/18
Direct Costs: $1,987,405 (Rounds: $236,946) |
Recent Publications:
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Lu Q, Gottlieb E, Rounds S. Effects of Cigarette Smoke on Pulmonary Endothelial Cells. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 4. doi: 10.1152/ajplung.00373.2017. [Epub ahead of print]
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Chambers E, Rounds S, Lu Q. Pulmonary Endothelial Cell Apoptosis in Emphysema and Acute Lung Injury. Adv Anat Embryol Cell Biol. 2018;228:63-86.
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Lu Q, Mundy M, Chambers E, Lange T, Newton J, Borgas D, Yao H, Choudhary G, Basak R, Oldham M, Rounds S. Alda-1 Protects Against Acrolein-Induced Acute Lung Injury and Endothelial Barrier Dysfunction. Am J Respir Cell Mol Biol. 2017 Dec;57(6):662-673.
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Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, Gillies H, Gladwin M, Gray MP, Hemnes AR, Herbst RS, Hernandez AF, Hill NS, Horn EM, Hunter K, Jing ZC, Johns R, Kaul S, Kawut SM, Lahm T, Leopold JA, Lewis GD, Mathai SC, McLaughlin VV, Michelakis ED, Nathan SD, Nichols W, Page G, Rabinovitch M, Rich J, Rischard F, Rounds S, Shah SJ, Tapson VF, Lowy N, Stockbridge N, Weinmann G, Xiao L. Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1661-1670.
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Vang A, Clements RT, Chichger H, Kue N, Allawzi A, O'Connell K, Jeong EM, Dudley SC Jr, Sakhatskyy P, Lu Q, Zhang P, Rounds S, Choudhary G. Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L748-L759.
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Sakhatskyy P, Wang Z, Borgas D, Lomas-Neira J, Chen Y, Ayala A, Rounds S, Lu Q. Double-hit mouse model of cigarette smoke priming for acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L56-L67.
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Okereke IC, Bates MF, Jankowich MD, Rounds SI,
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Borgas D, Chambers E, Newton J, Ko J, Rivera S, Rounds S, Lu Q. Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6. Am J Respir Cell Mol Biol. 2016 May;54(5):683-96.
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Sakhatskyy P, Gabino Miranda GA, Newton J, Lee CG, Choudhary G, Vang A, Rounds S, Lu Q. Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α. Microvasc Res. 2014 Jul;94:80-9.
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Dweik RA, Rounds S, Erzurum SC, Archer S, Fagan K, Hassoun PM, Hill NS, Humbert M, Kawut SM, Krowka M, Michelakis E, Morrell NW, Stenmark K, Tuder RM, Newman J; ATS Committee on Pulmonary Hypertension Phenotypes. An official American Thoracic Society Statement: pulmonary hypertension phenotypes. Am J Respir Crit Care Med. 2014 Feb 1;189(3):345-55.
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Maron BA, Goldstein RH, Rounds SI, Shapiro S, Jankowich M, Garshick E, Moy ML, Gagnon D, Choudhary G. Study design and rationale for investigating phosphodiesterase type 5 inhibition for the treatment of pulmonary hypertension due to chronic obstructive lung disease: the TADA-PHiLD (TADAlafil for Pulmonary Hypertension associated with chronic obstructive Lung Disease) trial. Pulm Circ. 2013 Dec;3(4):889-97.
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Aliotta JM, Pereira M, Amaral A, Sorokina A, Igbinoba Z, Hasslinger A, El-Bizri R, Rounds SI, Quesenberry PJ, Klinger JR. Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice. Cardiovasc Res. 2013 Dec 1;100(3):354-62.
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Lu Q, Sakhatskyy P, Newton J, Shamirian P, Hsiao V, Curren S, Gabino Miranda GA, Pedroza M, Blackburn MR, Rounds S. Sustained adenosine exposure causes lung endothelial apoptosis: a possible contributor to cigarette smoke-induced endothelial apoptosis and lung injury. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 1;304(5):L361-70.