PRIMO publications:

Perillo M, Swartz Z Wessel GM (2022). A conserved node in the regulation of Vasa between an induced and an inherited program of primordial germ cell specification. Developmental Biology 482: 28-32.


Leong J, Li Y, Uesaka M, Uchida Y, Omori A, Hao M, Wenting W, Dong Y, Ren Y, Zhang S, Zeng T, Wang F, Chen L, Wessel GM, Cameron RA, Livingston B, Bradham C, Wang W, Irie N (2021).  Derivedness index for estimating degree of phenotypic evolution of embryos: a study of comparative transcriptomic analyses of chordates and echinoderms. Frontiers in Cell and Developmental Biology (Evolutionary Developmental Biology) Nov 26;9:749963 PMCID: PMC8661034; DOI: 10.3389/fcell.2021.749963


Swartz Z, Tan HZ, Perillo, M, Fakhri N, Wessel, GM, Wikramayake A, Cheeseman I  (2021). Polarized Dishevelled dissolution and reassembly drives embryonic axis specification in sea star oocytes. Current Biology 31: 1-9.   


Scaffa A, Yao H, Oulhen N, Wallace J, Peterson AL, Rizal S, Ragavendran A, Wessel GM,. De Paepe ME, Dennery PA, (2021). Single-cell transcriptomics reveals lasting changes in the lung cellular landscape into adulthood after neonatal hyperoxic exposure Redox Dec;48:102091.Epub 2021 Aug 16.


Tilahun, L., Asrat, A., Wessel, G.M. Simachew A (2021). Microbial diversity in the hypersaline aquatic environments of the Danakil Depression, Ethiopia. African Journal of BioTechnology in press.


Wessel, GM, Wada Y, Yajima M, Kiyomoto M (2021). Sperm lacking bindin are infertile but are otherwise indistinguishable from wildtype sperm. Scientific Reports 11:21583


Wavreil FDM, Poon J,  Wessel GM, Yajima M. (2021). Light-induced, spatiotemporal control of protein in the developing embryo of the sea urchin. Developmental Biology 478: 13-24.


Wessel, GM, Wada Y, Yajima M, Kiyomoto M (2021). Bindin is essential for fertilization in the sea urchin. Proceedings of the National Academy of Sciences (USA) Aug 24; 118(34):e2109636118. doi: 10.1073/pnas.2109636118


Pieplow A, Dastaw M, Sakuma T, Sakamoto N, Yamamoto T, Yajima M, Oulhen N, Wessel GM (2021).  CRISPR-Cas9 editing of non-coding genomic loci as a means of controlling gene expression in the sea urchin. Developmental Biology Dev Biol.2021 Jan 19;S0012-1606(21)00015-4. doi: 10.1016/j.ydbio.2021.01.003.


Tilahun L, Asrat A, Wessel GM Simachew A (2021). In silico Determination of Nitrogen Metabolism in Microbes from Extreme Conditions using Metagenomics Archives of Microbiology, in press.


Perillo M, Oulhen N, Foster S, Spurrell M, Calestani C, Wessel GM, (2020). Regulation of dynamic pigment cell states at single-cell resolution. eLife 9:e60388 DOI:10.7554/eLife.60388. PMCID: PMC7455242


Foster S, Oulhen N, Wessel GM (2020). A single cell RNA-seq resource for early sea urchin development. Development. 2020 Sep 11;147(17):dev191528. doi: 10.1242/dev.191528. PMCID:PMC7502599


Wessel, G.M., Kiyomoto, M., Shen, T. Yajima, M. Genetic manipulation of the pigment pathway in a sea urchin reveals distinct lineage commitment prior to metamorphosis in the bilateral to radial body plan transition. Scientific Reports 10, 1973 (2020). PMCID: PMC7005274


Li Y, OmoriA, Flores RL, Satterfield S, Nguyen C, Ota T, Tsurugaya T, Ikuta T, Ikeo K, Kikuchi M, Leong JCK, Reich A, Hao M, Wan W, Dong Y, Ren Y, Zhang S, Zeng T, Uesaka M, Uchida Y, Li X, Shibata TF, Bino T, Ogawa K, Shigenobu S, Kondo M, Wang F, Chen L, Wessel GM, Saiga H, Cameron RA, Livingston B, Bradham C, Wang W, Irie N (2020). Genomic tests of body plan transitions from bilateral to pentameral symmetry in Echinoderms. Communications Biology  Jul 10;3(1):371. doi: 10.1038/s42003-020-1091-1. PMCID: PMC7351957


Perillo M, Pagano P, Spurrell M, Arnone I, Wessel GM. (2020). Methodology for Whole Mount and Fluorescent RNA in situ Hybridization in Echinoderms: Single, Double, and Beyond. Methods in Molecular Biology pg 195-216.


Wessel GM, Morita S, Oulhen N. (2020) Somatic cell conversion to a germ cell lineage - a violation or a revelation. Journal of Experimental Zoology B Molecular and Developmental Evolution


Duncan FE, Schindler K, Schultz RM Blengini C, Stein P, Stricker SA, Wessel GM, Williams CJ (2020). Unscrambling the oocyte and the egg: clarifying terminology of the female gamete in mammals. Mol Hum Reprod. 2020 Oct 6:gaaa066. doi: 10.1093/molehr/gaaa066. Online ahead of print. PMID: 33022047


Beyene E, Tefera A, Muleta D, Fantahun S, Wessel GM (2020). Molecular identification and performance evaluation of wild yeasts from different Ethiopian fermented products Journal of Food Science and Technology DOI: 10.1007/s13197-020-04377-7


Poon J, Fries A, Wessel GM, Yajima M, (2019) Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins. Nature Communications 10(1):3779 - 3795. doi: 10.1038/s41467-019-11560-8. PMCID: PMC6706577


Clark H, Knapik LO, Zhang Z, Wu X, Naik MT, Oulhen N, Wessel GM, Brayboy LM, (2019). Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary. Scientific Reports Jul 3;9(1):9616. doi: 10.1038/s41598-019-4602 PMCID: PMC6610133



Gebreslassie E, Tefera A, Muleta D, Kiros S, Wessel GM (2019). Optimization of the Cultivation Conditions of Indigenous Wild Yeasts and Evaluation of their Leavening Capacity. International Journal of Science. Vol 8: 15-23. doi: 10.18483/ijSci.2043 


Oulhen N, Swartz SZ, Wang L, Wikramanayake A, Wessel GM. (2019). Distinct transcriptional regulation of Nanos2 in the germ line and soma by the Wnt and delta/notch pathways. Dev Biol. 452(1):34-42. doi: 10.1016/j.ydbio.2019.04.010. PMCID: PMC6848975


Foster S+, Teo YV+, Neretti N, Oulhen N, Wessel GM (2019). Single cell RNA-seq in the sea urchin embryo shows marked cell-type specificity in the Delta/Notch pathway. Molecular Reproduction and Development Aug;86(8):931-934. doi: 10.1002/mrd.23181. Epub 2019 Jun 14. (+ co-first authors). PMCID: PMC6690749


Vecchioni S, Capece MC, Toomey E, Le N, Ray A, Greenberg A, Fujishima K, Urbina J, Paulino-Lima I, Pinheiro V, Shih J, Wessel GM, Wind S, Rothschild LJ. (2019). Construction and characterization of metal ion-containing DNA nanowires for synthetic biology and nanotechnology. Scientific Reports volume 9, Article number: 6942. PMCID: PMC6502794


Roux-Osovitz M, Foltz KR, Oulhen N, Wessel GM (2019).  Trapping, Tagging and Tracking: Tools for the Study of Proteins During Early Development of the Sea Urchin. Methods in Cell Biology 151:283-304. doi: 10.1016/bs.mcb.2018.11.003. PMCID: PMC7549693


Oulhen N. Foster S, Wray G, Wessel GM (2019). Identifying gene expression from single cells to single genes. Methods in Cell Biology 151:127-158. doi: 10.1016/bs.mcb.2018.11.018. PMCID: PMC7384399


Campanale J, Hamdoun A, Wessel GM, Su Y-H, Oulhen N (2019). Methods to label, isolate, and image sea urchin small micromeres. Methods in Cell Biology 150:269-292. doi: 10.1016/bs.mcb.2018.11.007. PMCID: PMC6487853


Lin C-Y, Oulhen N, Wessel GM, Su Y-H (2019). CRISPR/Cas9-mediated genome editing in sea urchins. Methods in Cell Biology 151:305-321. doi: 10.1016/bs.mcb.2018.10.004. PMCID: PMC7357425


Fresques T, Wessel GM (2018). Nodal induces sequential restriction of germ cell factors during primordial germ cell specification. Development Jan 22;145(2). pii: dev155663. doi: 10.1242/dev.155663. PMCID:PMC5825842


Wessel, G. M. (2018). Echinodermata. In M. K. Skinner (Ed.), Encyclopedia of Reproduction. vol. 6, pp. 533–545. Academic Press: Elsevier.


Calestani C, Wessel GM (2018). These Colors Don’t Run: Regulation of Pigment Biosynthesis in Echinoderms. Marine Organisms as Model Systems in Biology and Medicine. Kloc M, and Kubiak J. Editors SpringerNature. 2018;65:515-525. doi: 10.1007/978-3-319-92486-1_22. PMID:30083933


Brayboy LM Clark H, Schnirman R, Knapik L, Wessel GM (2018). Nitrogen mustard exposure perturbs oocyte mitochondrial physiology and alters reproductive outcomes.  Reproductive Toxicology Oct 9;82:80-87. PMID 30308227. doi: 10.1016/j.reprotox.2018.10.002. PMCID: PMC7050192


Tilahun B, Bahiru A, Tesfaye A, Muleta D, Terefework Z, and Wessel GM (2019) Molecular Characterization of fermenting Yeast Species from Fermenting Teff Dough during preparation of Injera using ITS DNA Sequence. International Journal of Food Science, Volume 2019, Article ID 1291863, 7 pages


Brayboy LM, Knapik LO, Long S, Westrick M, Wessel GM. (2018). Ovarian hormones modulate multidrug resistance transporters in the ovary. Contraception and Reprod Med. 3:26. PMID: 30460040; doi: 10.1186/s40834-018-0076-7. PMCID: PMC6236903


Tilahun B, Tesfaye A, Muleta D, Terefework Z, Bahiru A, Wessel G (2018) Isolation and Molecular Identification of lactic acid Bacteria using 16s rDNA from Fermented Teff (Eragrostis teff (Zucc.))  Dough.  International Journal of Food Science, Volume 2019, Article ID 1291863, 7 pages


Oulhen N, Wessel GM (2017). A quiet space during rush hour: Quiescence in primordial germ cells. Stem Cell Research 25: 296-299. PMCID: PMC5732843


Niikura K, Alam S, Naruse M, Jimbo M, Moriyama H, Reich A, Wessel GM, Matsumoto M (2017). Protein Kinase A Activity Leads to the Extension of the Acrosomal Process in Starfish Sperm Molecular Reproduction and Development Jul;84(7):614-625. doi: 10.1002/mrd.22824. Epub 2017 Jun 19.


Schudrowitz N, Takagi S, Wessel G, Yajima M. (2017). The germline factor DDX4 functions in blood-derived cancer cell phenotypes. Cancer Science Aug;108(8):1612-1619. doi: 10.1111/cas.13299. Epub 2017 Jul 11.


Shevidi S, Uchida A, Schudrowitz N, Wessel GM, Yajima M (2017). Single nucleotide editing without DNA cleavage using CRISPR/Cas9-deaminase in the sea urchin embryo. Developmental Dynamics 246:1036-1046. DOI: 10.1002/dvdy.24586 PMCID: PMC5872153


Bucci C, Francoeur M, McGreal J, Smolowitz R, Zazueta-Novoa V, Wessel GM, Gomez-Chiarri M. (2017) Sea Star Wasting Disease in Asterias forbesi along the Atlantic Coast of North America. PLoS ONE 12(12):e0188523. 10.1371/journal.pone.0188523 PMCID:PMC5724889

Oulhen N, Swartz Z, Laird J, Mascaro A, Wessel GM (2017). Transient Translational Quiescence in Primordial Germ Cells.  Development 144, 1201-1210 doi:10.1242/dev.144170


Brayboy LM, Oulhen N,  Long S, Voigt N, Raker C, Wessel GM (2017).Multidrug Resistance Transporter-1 and Breast Cancer Resistance Protein protect against ovarian toxicity, and are essential in ovarian physiology. Reproductive Toxicology 69: 121-131.


Oulhen N, Wessel GM (2016). Albinism as a visual, in vivo guide for CRISPR/Cas9 functionality in the sea urchin embryo. Molecular Reproduction and Development 2016 Dec;83(12):1046-1047. doi: 10.1002/mrd.22757.


Oulhen N, Heyland A, Carrier T, Zazueta-Novoa V, Fresques T, Laird J, Onorato T, Janies D, Wessel GM (2016). Regeneration in bipinnaria larvae of the bat star Patiria miniata induces rapid and broad new gene expression. Mechanisms of Development 142: 10-21. doi: 10.1016/j.mod.2016.08.003.


Oulhen N, Wessel GM (2016). Differential Nanos 2 protein stability results in selective germ cell accumulation in the sea urchin. Developmental Biology  418: 146-156 doi: 10.1016/j.ydbio.2016.07.007 PMCID: PMC5031544


Zazueta-Novoa, V, Onorato T, Luis Reyes Chavez G, Oulhen N, Wessel GM (2016) The complexity of yolk proteins and their dynamics in the sea star, Patiria miniata. Biological Bulletin Jun;230 (3):209-19. PMCID: PMC5103698 DOI: 10.1086/BBLv230n3p209


Fresques T, Swartz Z, Juliano C, Morino Y, Kikuchi M, Akasaka K, Wada H, Yajima M, Wessel GM (2016). The Diversity of Nanos Expression in Echinoderm Embryos Supports Different Mechanisms in Germ Cell Specification. Evolution & Development Jul;18(4):267-78. DOI:10.1111/ede.12197 PMCID: PMC4943673


Poon J, Wessel GM, Yajima M (2016).An unregulated regulator: Vasa expression in the development of somatic cells and in tumorigenesis. Developmental Biology 415: 24-32. doi:10.1016/j.ydbio.2016.05.012


Wessel GM (2016).Germ line mechanics – and unfinished business. In “Essays of Developmental Biology” (Ed. P. Wassarman) Current Topics in Developmental Biology Volume 117:553-66. doi: 10.1016/bs.ctdb.2015.11.030. Epub 2016 Jan 7. Elsevier Press, Amsterdam


Dresselhaus T, Sprunck S, Wessel GM (2016). Fertilization mechanisms in flowering plants. Current Biology 26(3):R125-39. doi: 10.1016/j.cub.2015.12.032.


Brayboy LM, Wessel GM (2016). The double-edged sword of the mammalian oocyte – advantages, drawbacks, and approaches for basic and clinical single cell analysis. Molecular Human Reproduction 22(4):311-318. doi:10.1093/molehr/gaw020 PMCID:PMC4767051


Reich A, Dunn C, Akasaka K, Wessel GM. (2015).Phylogenetic Analyses of Echinodermata Support the Sister Groups of Asterozoa and Echinozoa. PLoS One Mar 20; 10(3);e0119627. Doi:10.1371/journal.pone.0119627.  PMCID:PMC4368666


Yajima M, Wessel GM (2015).Essential elements for translation: the germ line factor, Vasa, functions broadly in somatic cells. Development 142(11):1960-70. doi: 10.1242/dev.118448. PMCID:PMC4460737


Swartz SZ, Wessel GM. (2015). Germ Line Versus Soma in the Transition from Egg to Embryo. In “The Maternal-to-Zygotic Transition” (Ed. H. Lipshitz) Current Topics in Developmental Biology V. 113. Elsevier Press, Amsterdam. Chapter 32.


Kelel M, Abera G Yisma A, Molla B, Gebre N, Adugna T, Wessel G (2014). Isolation of phosphate solubilizing bacteria from Acacia tree rhizosphere soil. Journal of Microbiology and Biotechnology Research 4: 9-13. 


Angione S, Oulhen N, Brayboy L, Tripathi A, Wessel GM (2014). Simple Perfusion Apparatus (SPA) for Manipulation, Tracking, and Study of Oocytes and Embryos.  Fertility and Sterility 103(1):281-290.e5. doi: 10.1016/j.fertnstert.2014.09.039. PMCID:PMC4768872


Ramos I, Wessel G. (2014). Two-pore Channels (TPCs) function in calcium regulation in sea star oocytes and embryos. Development 141(23):4598-609. doi: 10.1242/dev.113563. PMCID: PMC4302940


Kelel, M, Temam S, Mandefro A, Asfaw F, Wessel GM (2014). Bovine Tuberculosis Prevalence in Slaughtered Cattle at Gondar Elfora Abattoir, Based on Meat Inspection and Microscopic Methods. American-Eurasian Journal of Scientific Research 9 (5): 114-119.


Swartz SZ, Reich AM, Oulhen N, Raz T, Milos PM, Campanale JP, Hamdoun A, Wessel GM. (2014). Deadenylase depletion protects inherited mRNAs in primordial germ cells. Development 141(16):3134-42. doi: 10.1242/dev.110395. PMCID:PMC4197533


Zazueta V, Wessel GM (2014). Protein degradation machinery is present broadly during early development in the sea urchin. Gene Expression Patterns 15(2):135-41. doi: 10.1016/j.gep.2014.06.002. PMCID: PMC4125525


Yewhalaw D, Kelel M, Getu E, Temam S, Wessel G. (2014). Blood meal sources and sporozoite rates of Anophelines in Gilgel-Gibe dam area, Southwestern Ethiopia. African Journal of Vector Biology September 2014


Oulhen N, Xu D, Wessel GM (2014). Conservation of sequence and function in fertilization of the cortical granule serine protease in echinoderms. BBRC 450: 1135-1141. PMCID:PMC4133295


Campanela J, Oulhen N, Wessel G, Hamdoun A (2014).  Migration of sea urchin primordial germ cells. Developmental Dynamics 243: 917-27.  PMCID: PMC4164171


Oulhen N, Onorato T, Ramos I, Wessel GM (2014). Dysferlin is essential for endocytosis in the sea star oocyte. Developmental Biology 388: 94-102. DOI information: 10.1016/j.ydbio.2013.12.018. PMCID: PMC3982204


Yajima M, Gustafson EA, Song JL, Wessel GM (2014). Piwi regulates Vasa accumulation during embryogenesis in the sea urchin. Developmental Dynamics 243:451–458. PMCID: PMC4018429


Juliano CE, Reich A, Liu N, Götzfried J, Zhon M, Uman S, Reenan, R, Wessel GM, Steele RE, Lin H (2014). PIWI-piRNA pathway function in Hydra somatic stem cells Proceedings of the National Academy of Sciences 111, no. 1 (2014): 337–342. doi:10.1073/pnas.1320965111 PMCID: PMC3890812