Wong Lab Publications







At Brown (Preprint, Under Review)

22. A.S. Brodsky,* J. Khurana, K. Guo, E.Y. Wu, D. Yang, I.Y. Wong, E.D. Uzun, and M.B. Resnick."Somatic Mutations in Collagens are Associated with a Distinct Tumor Environment and Overall Survival in Gastric Cancer." bioRxiv: 2021.01.19.426938 (2021)

At Brown (Peer-Reviewed)

21. D. Bhaskar, W.Y. Zhang, and I.Y. Wong.* "Topological Data Analysis of Collective and Individual Epithelial Cells using Persistent Homology of Loops." Soft Matter. 17, 4653-4664 (2021)

20. A. Markoski, I.Y. Wong,* and J.T. Borenstein.* "3D Printed Monolithic Device for the Microfluidic Capture, Perfusion, and Analysis of Multicellular Spheroids." Frontiers in Medical Technology. 3, 646441 (2021)

19. S.E. Leggett, A.M. Hruska, M. Guo, and I.Y. Wong.* "The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems." Cell Communication and Signaling. 19, 32 (2021)

18. M. Ding, L. Jing, H. Yang, C.E. Machnicki, X. Fu, K. Li, I.Y. Wong,* and P.-Y. Chen.* "Multifunctional soft machines based on stimuli-responsive hydrogels: from freestanding hydrogels to smart integrated systems." Materials Today Advances. 8, 100088 (2020)

17. S.E. Leggett,# M. Patel,# T.M. Valentin, L. Gamboa, A.S. Khoo, E.K. Williams, C. Franck, and I.Y. Wong.* "Mechanophenotyping of 3D Multicellular Clusters using Displacement Arrays of Rendered Tractions." Proceedings of the National Academy of Sciences, USA. 117 (11) 5655-5663 (2020)

16. S.E. Leggett, Z.J. Neronha, D. Bhaskar, J.Y. Sim, T.M. Perdikari, and I.Y. Wong.* "Motility-limited aggregation of mammary epithelial cells into fractal-like clusters." Proceedings of the National Academy of Sciences, USA. 116(35), 17298-17306 (2019)

15. A.S. Khoo,# T.M. Valentin,# S.E. Leggett, D. Bhaskar, E.M. Bye, S. Benmelech, B.C. Ip, and I.Y. Wong.* "Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable 3D Silk-Collagen Hydrogels"  ACS Biomaterials Science & Engineering. 5(9), 4341-4354 (2019)

14. C.E. Machnicki, F. Fu, L. Jing, P.-Y. Chen,* and I.Y. Wong.* "Mechanochemical Engineering of 2D Materials for Multiscale Biointerfaces."  Journal of Materials Chemistry B. 7, 6293-6309 (2019)

13. T.M. Valentin, E.M. DuBois, C.E. Machnicki, D. Bhaskar, F.R. Cui, and I.Y. Wong.* "3D Printed Self-Adhesive PEGDA-PAA Hydrogels as Modular Components for Soft Actuators and Microfluidics." Polymer Chemistry. 10, 2015-2028 (2019)

12. T.M. Valentin, A.K. Landauer, L.C. Morales, E.M. DuBois, S. Shukla, M. Liu, L.H. Stephens, C. Franck, P.-Y. Chen, and I.Y. Wong.* "Alginate-graphene oxide hydrogels with enhanced ionic tunability and chemomechanical stability for light-directed 3D printing." Carbon. 143, 447-456 (2019)

11. M. Patel, S.E. Leggett, A.K. Landauer, I.Y. Wong, and C. Franck.* "Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields." Scientific Reports. 8, 5581 (2018)

10. P.-Y. Chen,* M. Zhang, M. Liu, I.Y. Wong,* and R.H. Hurt.* "Ultra-Stretchable Graphene-Based Molecular Barriers for Chemical Protection, Detection, and Actuation." ACS Nano. 12(1), 234-244 (2018)

9. T.M. Valentin, S.E. Leggett, P.-Y. Chen, J.K. Sodhi, L.H. Stephens, H.D. McClintock, J.Y. Sim, and I.Y. Wong.* "Stereolithographic Printing of Ionically-Crosslinked Alginate Hydrogels for Degradable Biomaterials and Microfluidics." Lab on a Chip 17, 3474-3488 (2017)

8. S.E. Leggett, A.S. Khoo, and I.Y. Wong.* 

7. P.-Y. Chen,* M. Liu, Z. Wang, R.H. Hurt* and I.Y. Wong.*

6. P.-Y. Chen,* ,* and

5. S.E. Leggett, J.Y. Sim, J.E. Rubins, Z.J. Neronha, E.K. Williams and I.Y. Wong.* "Morphological Single Cell Profiling of the Epithelial-Mesenchymal Transition." Integrative Biology. 8, 1133-1144 (2016)

4. M. Gamboa Castro, S.E. Leggett and I.Y. Wong.* "Clustering and Jamming in Epithelial-Mesenchymal Co-Cultures." Soft Matter. 12, 8327-8337 (2016)

3. P.-Y. Chen,* J. Sodhi, Y. Qiu, T.M. Valentin, R. Spitz Steinberg, Z. Wang, R.H. Hurt* and I.Y. Wong.* "Multiscale Graphene Topographies Programmed by Sequential Mechanical Deformation." Advanced Materials. 28(18), 3564-3571 (2016)

2. Z. Wang,# D. Tonderys,# S.E. Leggett,# E.K. Williams, M.T. Kiani, R. Spitz-Steinberg, Q. Yang, I.Y. Wong,* and R.H. Hurt.* "Wrinkled, wavelength-tunable graphene-based surface topographies for directing cell alignment and morphology."  Carbon. 97, 14-24 (2016) (Cover, Special Issue on Biomedical Applications of Carbon Nanomaterials)

1. I.Y. Wong,* S.N. Bhatia, and M. Toner*. “Nanotechnology: emerging tools for biology and medicine.” Genes & Development. 27, 2397-2408 (2013)

At Brown (Non-Peer Reviewed Commentaries)

10. I.Y. Wong.* "Emerging Biomimetic Assays for Cancer Cell Invasion." ASME Alliance of Advanced Biomedical Engineering (White Paper, 2019)

9. S.E. Leggett and I.Y. Wong.* "Nanomedicine: Catching tumour cells in the zone." Nature Nanotechnology. 12, 191-193 (2017).

8. I.Y. Wong. "Use the force." Science Translational Medicine. 8, 325ec25 (2016)

7. I.Y. Wong. "Neutrophils: Harbingers of metastasis?Science Translational Medicine7, 319ec220 (2015) 

6. I.Y. Wong. "Singled out: Exploring epigenetics." Science Translational Medicine7, 313ec195 (2015) 

5. I.Y. Wong. "Platelet impersonation." Science Translational Medicine7, 307ec169 (2015)

4. I.Y. Wong. "Cells choose the path less potholed." Science Translational Medicine. 7, 301ec144 (2015)

3. I.Y. Wong. "Electronics, freshly squeezed." Science Translational Medicine. 7, 295ec117 (2015)

2. I.Y. Wong. "A graphene security blanket." Science Translational Medicine. 7, 289ec89 (2015)

1. I.Y. Wong. "Singled Out: Profiling Metabolic and Proteomic Heterogeneity." Science Translational Medicine. 7, 283ec64 (2015)

Prior to Brown (Peer-Reviewed)

13. I.Y. Wong, S. Javaid, E.A. Wong, S. Perk, D.A. Haber, M. Toner, D. Irimia. “Collective and individual migration following the epithelial–mesenchymal transition.” Nature Materials. 13, 1063-1071 (2014)

12. S. Mittal,# I.Y. Wong,# (Co-First Authors), A.A. Yanik, W.M. Deen, M. Toner. “Discontinuous Nanoporous Membranes Reduce Non-Specific Fouling for Immunoaffinity Cell Capture.” Small. 9(24), 4207-14 (2013).

11. S. Mittal, I.Y. Wong, W.M. Deen, M. Toner. “Antibody-Functionalized Fluid-Permeable Surfaces for Rolling Cell Capture at High Flow Rates.” Biophysical Journal. 102(4), 721-30 (2012). (Cover)

10. A. Hoerning, K. Koss, D. Datta, L. Boneschansker, C.N. Jones, I.Y. Wong, D. Irimia, K. Calzadilla, F. Benitez, P.F. Hoyer, W.E. Harmon, D.M. Briscoe. “Subsets of Human CD4+ T Regulatory Cells Express the Peripheral Homing Receptor CXCR3.” European Journal of Immunology. 41(8), 2291-302 (2011).

9. V. Ambravaneswaran, I.Y. Wong, A.J. Aranyosi, M. Toner and D. Irimia. “Directional Decisions during Neutrophil Chemotaxis inside Bifurcating Channels.” Integrative Biology. 2(11), 639-647 (2010).

8. I.Y. Wong and N.A. Melosh. “An Electrostatic Model for DNA Surface Hybridization.” Biophysical Journal. 98(12) 2954-63 (2010).

7. I.Y. Wong, B.D. Almquist and N.A. Melosh. “Dynamic actuation using nano-bio interfaces.” Materials Today. 13(6), 14-22 (2010). (Invited Feature and Cover)

6. P. Verma, I.Y. Wong and N.A. Melosh. “Continuum model of mechanical interactions between biological cells and artificial nanostructures.” Biointerphases. 5(2), 37 (2010)

5. I.Y. Wong and N.A. Melosh. “Directed Hybridization and Melting of DNA using Counterion-Screened Electric Fields.” Nano Letters. 9(10) 3521-6 (2009)

4. I.Y. Wong, M.J. Footer and N.A. Melosh. "Electronically Activated Actin Protein Polymerization and Alignment.” Journal of the American Chemical Society. 130(25), 7908-15 (2008).

3. I.Y. Wong, M.J. Footer and N.A. Melosh. "Dynamic Control of Biomolecular Activity using Electrical Interfaces." Soft Matter. 3, 267 (2007). (Invited Feature and Cover)

2. A.D. Dinsmore, V. Prasad, I.Y. Wong and D.A. Weitz. "Microscopic Structure and Elasticity of Weakly Aggregated Colloidal Gels." Physical Review Letters. 96, 185502 (2006)

1. I.Y. Wong, M.L. Gardel, D.R. Reichman, E.R. Weeks, M.T. Valentine, A.R. Bausch and D.A. Weitz, "Anomalous Diffusion Probes Microstructure Dynamics of Entangled F-actin Networks." Physical Review Letters. 92, 178101 (2004).