NMR advance brings proteins into the open

A permissive captor

A computer rendering depicts a GroEL protein hunting down an Aβ protein. Four complementary styles of nuclear magnetic resonance spectroscopy contributed to an understanding of the protein-to-protein interaction. Credit: Fawzi lab/Brown University

A key protein interaction, common across all forms of life, had eluded scientists’ observation until a team of researchers cracked the case by combining data from four different techniques of nuclear magnetic resonance spectroscopy.