Newly found CLAMP protein regulates genes

Dosage compensation: A male lifeline

“This is the last step of these signaling pathways that make the ultimate regulatory decision about whether you are going to turn on a gene or keep it off,” says Erica Larschan, right, with graduate students Marcela Soruco, left, and Jessica Chery. Credit: Mike Cohea/Brown University

A newly discovered protein, found in many species, turns out to be the missing link that allows a key regulatory complex to find and operate on the lone X chromosome of male fruit flies, bringing them to parity with females. Called CLAMP, the protein provides a model of how such regulatory protein complexes find their chromosome targets.