Fly study finds two new drivers of RNA editing

More complicated than anyone had guessed

Studies in the RNA of fruit flies discovered two new mechanisms that can control editing at distant parts of the RNA molecule. Robert Reenan has studied the para gene and its expression for almost 25 years. Credit: David Orenstein/Brown University

A new study in Nature Communications finds that RNA editing is not only regulated by sequences and structures near the editing sites but also by ones found much farther away. One newly discovered structure gives an editing enzyme an alternate docking site. The other appears to throttle competing splicing activity.