CAPB Publications

  • Recent publications by CAPB researchers, 2016-present (in PubMed)
  • CAPB publications on spheroids, microtissues and high-throughput screening, 2010 - present (in PubMed)

Featured CAPB publications


  • Krewski D, Acosta, Jr., D, Andersen M, Andersen H, Bailar, 3rd JC, Boekeheide K, Brent R, Charnley G, Cheung VG, Green Jr., S, Kelsey KT, Kerkyliet NI, Li AA, McCray L, Meyer O, Patterson RD, Pennie W, Scala RA, Solomon GM, Stephens M, Yager J, and Zeise L. Toxicity testing in the 21st century: A vision and a strategy. J Toxicol. Environ. Health B Crit Rev, 13(2-4): 51-138. (2010). PMC4410863


  • Achilli T-M, McCalla S, Tripathi A, and Morgan JR. Quantification of the Kinetics and Extent of Self-Sorting in Three Dimensional Spheroids. Tissue Eng. 18: 302-309 (2012). PMC3312373
  • Achilli T-M, Meyer J, and Morgan JR. Advances in the formation, use, and understanding of multi-cellular spheroids. Expert Opin. Biol. Ther., 12(10): 1347-60 (2012).
  • Bao BA, Lai CPK, Naus CC, and Morgan JR. Pannexin 1 Drives Multicellular Compaction Via a Signaling Cascade that Upregulates Cytoskeletal Function. J. Biol Chem. 287: 8407-8416, (2012). PMC3318751
  • Desroches BR, Zhang P, Choi B, Maldonado AE, Rago A, Liu GX, Nath N, King ME, Hartmann KM, Yang B, Koren G, Morgan JR, and Mende U. Functional Scaffold-free Cardiac Microtissues: A Novel Model for the Investigation of Heart Cells. Am J Physiol. Heart Circ. Physiol 302: H22031-H220442 (2012). PMC3362102
  • Ho, DN, Kohler N, Sigdel A, Killuri R, Morgan JR, Xu C, Sun SS. Penetration of Endothelial Cell Coated Multicellular Tumor Spheroids by Iron Oxide Nanoparticles. Theranostics. 2: 66-75, (2012). PMC3263517
  • Sanchez VC, Jachak A, Hurt RH, Kane AB. Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review. Chem Res Toxicol, 25(1): 15-34 (2012). PMC3259226


  • Nel AE, Nasser E, Godwin H, Avery D, Bahadori T, Bergeson l, Beryt E, Bonner JC, Boverhof D, Carter J, Castranova V, Deshazo JR, Hussain SM, Kane AB, Klaessig F, Kuempel E, Lafranconi M, Landsiedel R, Malloy T, Miller MB, Morris J, Moss K, Oberdoster G, Pinkerton K, Pleus RC, Shatkin JA, Thomas R, Tolaymat T, Wang A, Wong J. A Multi-stakeholder Perspective on the Use of Alternative Test Strategies for Nanomaterial Safety Assessment. ACS Nano, 7(8): 6422-33 (2013). PMC4004078


  • Achilli TM, McCalla S, Meyer J, Tripathi A, Morgan JR. Multilayer Spheriods to Quantify Drug Uptake and Diffusion in 3D. Mol Pharm 11: 2071-81 (2014). PMC4096226
  • Rodd AL, Creighton MA, Vaslet CA, Rangel-Mendez JR, Hurt RH, Kane AB. Effects of Surface-Engineered Nanoparticle-Based Dispersants for Marine Oil Spills on the Model Organism Artemia franciscana. Environ Sci Technol, 48: 6419-27 (2014). PMC4046867


  • Boutin ME and Hoffman-Kim D. Application and assessment of optical clearing methods for imaging of tissue-engineered neural stem cell spheres. Tissue Eng Part C Methods 21(3): 292-302. (2015). PMC4346659
  • Curran S, Achilli T-M, Leary E, Wilks B, Vantangoli MM, Boekelheide K, and Morgan JR. A 3D Spheroid System to Evaluate Inhibitors of the ABCG2 Transporter in Drug Uptake and Penetration. TECHNOLOGY 3: 54-63, (2015).
  • Curran S, Vantangoli MM, Boekelheide K, and Morgan JR, Architecture of Chimeric Spheroids Controls Drug Transport. Cancer Microenvironment 8: 101-109, (2015). PMC4542826
  • Dingle Y-TL., Boutin ME, Chirila AM, Livi LL, Labriola NR, Jakubek LM, Morgan JR, Darling EM, Kauer JA, Hoffman-Kim D. 3D Neural Spheroid Culture: An In Vitro Model for Cortical Studies. Tissue Eng Part C Methods 21(12): 1274-83 (2015). PMC4663656
  • Kabadi PK, Vantangoli MM, Rodd AL, Leary E, Madnick SJ, Morgan JR, Kane A, and Boekelheide K. Into the Depths: Techniques for In Vitro Three-Dimensional Microtissue Visualization. Biotechniques 59(5): 279-86 (2015). PMC4804457
  • Vantangoli MM, Madnick SJ, Huse SM, Weston P, Boekelheide K. MCF-7 Human Breast Cancer Cells Form Differentiated Microtissues in Scaffold-Free Hydrogels. PLoS ONE 10(8): e0135426 (2015). PMC4534042


  • Vantangoli, M.M., S. Wilson, S.J. Madnick, S.M. Huse, and K. Boekelheide, Morphologic effects of estrogen stimulation on 3D MCF-7 microtissues. Toxicol Lett, 2016. 248: p. 1-8. PMC4803074
  •  Vantangoli, M.M., S.J. Madnick, S. Wilson, and K. Boekelheide, Estradiol Exposure Differentially Alters Monolayer versus Microtissue MCF-7 Human Breast Carcinoma Cultures. PLoS One, 2016. 11(7): p.  PMC4933361 e0157997. 
  • Wang Z, Tonderys D, Leggett SE, Williams EK, Kiani MT, Spitz-Steinberg R, Yang Q, Wong IY, Hurt RH. Wrinkled, Wavelength-Tunable Graphene-Based Surface Topographies for Directing Cell Alignment and Morphology. Carbon N.Y., 1(97): 14-24 (2016). PMC4384125
  • Wang, Z., D. Tonderys, S.E. Leggett, E.K. Williams, M.T. Kiani, R.S. Steinberg, Y. Qiu, I.Y. Wong, and R.H. Hurt, Wrinkled, wavelength-tunable graphene-based surface topographies for directing cell alignment and morphology. Carbon, 2016. 97: p. 14-24.  PMC4384125


  • Kofron CM, Mende U. In vitro models of the cardiac microenvironment to study myocyte and non-myocyte crosstalk: bioinspired approaches beyond the polystyrene dish. J Physiol 595(12):3891-3905 (2017).
  • Kofron CM*, Kim TY*, King ME, Xie A, Feng F, Park E, Qu Z, Choi B-R*, Mende U*. Gaq-activated fibroblasts induce cardiomyocyte action potential prolongation and automaticity in a 3D microtissue environment. Am J Physiol Heart Circ Physiol 313(4): H810-H827 (2017).
  • Labriola NR, Mathiowitz E, Darling EM. (2017) Fabricating polyacrylamide microbeads by inverse emulsification to mimic the size and elasticity of living cells. Biomater Sci. 5:41-45. PMCID: PMC5201106


  • Kim TY*, Kofron CM*, King ME, Marks AR, Okundaye AO, Qu Z, Mende U*, Choi B-R*. Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts. PLoS One 13(5): e0196714 (2018).
  • Labriola NR, Sadick JS, Morgan JR, Mathiowitz E, Darling EM. (2018) Cell mimicking microparticles influence the organization, growth, and mechanophenotype of stem cell spheroids. Ann Biomed Eng. 46(8): 1146-1159. PMCID: PMC6039261
  • Labriola NR, Azagury A, Gutierrez R, Mathiowitz E, Darling EM. (2018) Concise Review: Fabrication, customization, and application of cell mimicking microparticles in stem cell science. Stem Cell Transl Med. (7):232-240. PMCID: PMC5788880


  • Dent MP, Madnick SJ, Hall S, Vantangoli Policelli M, Bars C, Li H, Amin A, Carmichael PL, Martin FL, Boekelheide K. A human-derived prostate co-culture microtissue model using epithelial (RWPE-1) and stromal (WPMY-1) cell lines. Toxicol In Vitro. 2019 Oct;60:203-211 PMC6717042
  • Kabadi PK, Rodd AL, Simmons AE, Messier NJ, Hurt RH, Kane AB. A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations. Particle and fibre toxicology, 16(1):15 (2019). PMC6448215
  • Shah MK, Leary EA, Darling EM. (2019) Integration of hyper-compliant microparticles into a 3D melanoma tumor model. J Biomech. 82(3): 46-53. PMCID: PMC6310620.