Changes in Community Structure and Functional Responses of the Human Microbiome During Antibiotic Treatment in the Outpatient Setting

Current antibiotic therapy can lead to microbiome related complications and shifts in microbial populations that can contribute to the spread of antibiotic resistance. The work proposed here will transcriptionally profile the impacts of antibiotics on the composition and function of the oral microbiome in clinical samples. This functional information can identify therapies that more effectively utilize our current arsenal of antimicrobials in order to combat the impending antibiotic resistance crisis.