Publications

Project 1: Boekelheide Project 2: Kane   Project 3: Suuberg Project 4: Hurt 
Core 2: RTC Core 3: CEC Core 4: MPC Core 5: TC

PROJECT 1: Mechanism of Toxicant-induced Testicular Sensitization
Kim Boekelheide, M.D., Ph.D.

2016
Dere, E., Huse, S., Hwang, K., Sigman, M., Boekelheide, K. (2016). Intra- and Inter-Individual Differences in Human Sperm DNA Methylation. Andrology, 4(5):832-42.
PubMed Listing 

Dere, E., Wilson, S., Anderson, L., & Boekelheide, K. (2016). Sperm Molecular Biomarkers Are Sensitive Indicators of Testicular Injury Following Subchronic Model Toxicant Exposure. Toxicological Sciences, 153(2):327.
PubMed Listing

2014
Catlin N, Huse SM, Boekelheide K (2014). The stage-specific testicular germ cell apoptotic response to low dose x-irradiation and 2,5-hexanedione combined exposure. I. Validation of the laser capture microdissection method for qRT-PCR array application. Toxicol Pathol, 42:1221-1228. 
PubMed Listing

Catlin N, Huse SM, Boekelheide K. (2014). The stage-specific testicular germ cell apoptotic response to low dose x-irradiation and 2,5-hexanedione combined exposure. II. qRT-PCR array analysis reveals dose dependent adaptive alterations in the apoptotic pathway. Toxicol Pathol, 42:1229-1237.
PubMed Listing

Rider C, Boekelheide K, Catlin N, Gordon C, Morata T, Sexton K, Simmons J (2014). Cumulative Risk: Toxicity and Interactions of Physical and Chemical Stressors. Toxicol Sci, 137: 3-11. 
PubMed Listing

2013
Campion SN, Aubrecht J, Boekelheide K, Brewster D, Vaidya V, Anderson L, Burt D, Dere E, Hwang K, Pacheco S, Saikumar J, Schomaker S, Sigman M, Goodsaid F (2013). The Current Status of Biomarkers for Predicting Toxicity. Expert Opin Drug Metab Toxicol, 9(11): 1391-408.
PubMed Listing

Dere E, Anderson LM, Coulson M, McIntyre BS, Boekelheide K, Chapin RE (2013). SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, microRNAs and Sperm Signatures. Toxicol Sci, 136, 265-73. 
PubMed Listing 

Dere E, Anderson LM, Hwang K, Boekelheide K (2013). Biomarkers of chemotherapy-induced testicular damage. Fertil Steril, 100: 1192-202.
PubMed Listing

Thompson MR, Boekelheide K (2013). Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999–2004): Body burden and risk factors. Env Res 121: 23-30. 
PubMed Listing 

2012
Campion SN, Catlin N, Houseman EA, Hensley J, Sui Y, Gaido KW, Wu Z, Boekelheide K. Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposure. Reprod Toxicol. 
PubMed Listing

Pacheco, S.E., Anderson, L.M., Boekelheide, K. Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting. J. Androl. 
PubMed Listing

2011
Pacheco SE, Houseman EA, Christensen BC, Marsit CJ, Kelsey KT, Sigman M, Boekelheide K. Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm. PLoS ONE 
PubMed Listing

2010
Boekelheide, K., Campion, S.N. Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects. Toxicol Sci. 
PubMed Listing

Campion, S.N., Houseman, E.A., Sandrof, M.A., Hensley, J., Sui, Y., Gaido, K.W., Wu, Z., Boekelheide, K. Suppression of Radiation-induced Testicular Germ Cell Apoptosis. II. Gene Array Analysis Reveals Adaptive Changes in Cell Cycle and Cell Death Pathways. Toxicol Sci. 
PubMed Listing

Campion, S.N., Sandrof, M.A., Yamasaki, H., Boekelheide, K. Suppression of Radiation-induced Testicular Germ Cell Apoptosis. III. Candidate Gene Analysis Identifies a Role for Fas in the Attenuation of X-ray-induced apoptosis. Toxicol Sci. 
PubMed Listing

Yamasaki, H., Sandrof, M.A., Boekelheide, K. Suppression of Radiation-induced Testicular Germ Cell Apoptosis by 2,5-Hexanedione Pretreatment. I. Histopathological Analysis Reveals Stage-Dependence of Attenuated Apoptosis. Toxicol Sci. 
PubMed Listing

2008
Bryant, B.H., Yamasaki, H., Sandrof, M., Boekelheide, K. Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat. Toxicol. Pathol. 
PubMed Listing

Klysik, J., Theroux, S.J., Sedivy, J.M., Moffit, J.S., Boekelheide, K. Signaling crossroads: The function of Raf kinase inhibitory protein in cancer, the central nervous system. Cell Signal. 
PubMed Listing

2007

Boekelheide, K. Toxicological Highlight - Mixed Messages. Toxicol. Sci. 
Online access

Bryant, B.H., Boekelheide, K. Time-dependent changes in post-mortem testis histopathology in the rat. Toxicol. Pathol. 
PubMed Listing

Moffit, J.S., Boekelheide, K., Sedivy, J.M., Klysik, J. Mice lacking Raf kinase Inhibitor Protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury. J. Androl. 
PubMed Listing

Moffit, J.S., Bryant, B.H., Hall, S.J., Boekelheide K. Dose-dependent effects of Sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis. Toxicologic Pathol. 
PubMed Listing

Rasoulpour, R.J., Boekelheide, K. NF-kappaB activation elicited by ionizing radiation is proapoptotic in testis. Biol. Reprod. 
PubMed Listing

2006

Rasoulpour, R.J., Boekelheide, K. The Sycp1-Cre transgenic mouse and male germ cell inhibition of NF-kappa b. J. Androl. 
PubMed Listing

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PROJECT 2: Adverse Human Health Impacts of Nanomaterials 

Agnes Kane, M.D., Ph.D.

2016

Holden PA, Gardea-Torresdey JL, Klaessig F, Turco RF, Mortimer M, Hund-Rinke K, Cohen Hubal EA, Avery D, Barceló D, Behra R, Cohen Y, Deydier-Stephan L, Ferguson PL, Fernandes TF, Herr Harthorn B, Henderson WM, Hoke RA, Hristozov D, Johnston JM, Kane AB, Kapustka L, Keller AA, Lenihan HS, Lovell W, Murphy CJ, Nisbet RM, Petersen EJ, Salinas ER, Scheringer M, Sharma M, Speed DE, Sultan , Westerhoff P, White JC, Wiesner MR, Wong EM, Xing B, Steele Horan M, Godwin HA, Nel AE. (2016). Considerations of environmentally relevant test conditions for improved evaluation of ecological hazards of engineered nanomaterials. Environemental Science & Technology, 50(12):6124-45.
PubMed Listing

Kuempel ED, Jaurand MC, Moller P, Morimoto Y, Kobayashi N, Pinkerton KE, Sargent LM, Vermeulen RC, Fubini B, Kane AB. (2016). Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. Critical Review of Toxicology, 18:1-58.
PubMed Listing

Wang Z, von dem Bussche A, Qiu Y, Valentine TM, Gion K, Kane AB, Hurt RH. (2016). Chemical dissolution pathways of MoS2 nanosheets in biological and environmental media. Environemental Science & Technology, 50(13):7208-17.
PubMed Listing

2015

Godwin H, Nameth C, Avery D, Bergeson LL, Bernard D, Beryt E, Boyes W, Brown S, Clippinger AJ, Cohen Y, Doa M, Hendren CO, Holden P, Houck K, Kane AB, Klaessig F, Kodas T, Landsiedel R, Lynch I, Malloy T, Miller MB, Muller J, Oberdorster G, Petersen EJ, Pleus RC, Sayre P, Stone V, Sullivan KM, Tentschert J, Wallis P, Nel AE. 2015. Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making. ACS Nano. 9(4):3409-17. doi: 10.1021/acsnano.5b00941. PMID: 25791861
PubMed Listing

Kabadi PK, Vantangoli MM, Rodd AL, Leary E, Madnick SJ, Morgan JR, Kane, AB, Boekelheide, K. 2015. Into the depths: Techniques for in vitro three-dimensional microtissue visualization. Biotechniques. 1:59(5):279-86.
PubMed Listing

2014

Qiu Y, Wang Z, Owens AC, Kulaots I, Chen I, Kane AB, Hurt RH. (2014) Antioxidant chemistry of grapheme-based materials and its role in oxidation protection technology. Nanoscale, 6(20): 11744-55.
PubMed Listing

Rodd AL, Creighton MA, Vaslet CA, Rangel-Mendez JR, Hurt RH, Kane AB (2014). Effects of surface-engineered nanoparticle-based dispersants for marine oil spills on the model organism Artemia franciscana. Environ Sci Technol, 48: 6419-6427.
PubMed Listing

2013

Creighton M, Rene Rangel-Mendez J, Huang J, Kane A, Hurt R (2013). Graphene Induced Optical and Adsorptive Artifacts During In Vitro Toxicology Assays. Small 9(11): 1921-1927.
PubMed Listing 

Li Y, Yuan H, von dem Bussche A, Creighton M, Hurt RH, Kane AB, Gao H (2013). Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites. Proc Natl Acad Sci, 110(30): 12295-300.
PubMed Listing  

Wang Z, von dem Bussche A, Kabadi PK, Kane AB, Hurt RH (2013). Biological and environmental transformations of copper-based nanomaterials. ACS Nano 7: 8715-27.
PubMed Listing  

2012

Sanchez V, Jachak A, Hurt, RH, Kane AB. Biological interactions of graphene-family nanomaterials. Chem. Res. Toxicol. 
PubMed Listing

2011

Broaddus, V.C., Everitt, J.I., Black, B., Kane, A.B. Non-neoplastic and neoplastic endpoints following fiber exposure. J. Toxicol. And Environ. Health. 
PubMed Listing

Liu X, Sen S. Liu J, Kulaots I, Geohegan D, Kane AB, Palmore T, Hurt RH. Antioxidant deactivation on graphene nanocarbon surfaces. Small. 
PubMed Listing

Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt RH, Kane AB. Bioavailability, intracellular mobiliztion of nickel and HIF-1? activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci. 
PubMed Listing

Sanchez, V.C., Weston, P., Yan, A., Hurt, R.H., Kane, A.B. A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials. Particle and Fibre Toxicology. 
PubMed Listing

Shi X, von dem Bussche A, Hurt RH, Kane AB, Gao H. Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation. Nat. Nanotechnol. 
PubMed Listing

2010

Pietruska, J.R., Johnston, T., Zhitkovich, A, Kane A.B. XRCC1 Deficiency Sensitizes Human Lung Epithelial Cells to Genotoxicity by Crocidolite Asbestos and Libby Amphibole. Environ Health Perspect. 
PubMed Listing

Lau, B.W., Kane, A.B. SDF1/CXCL12 is involved in recruitment of stem-like progenitor cells to orthotopic murine malignant mesothelioma spheroids. Anticancer Res. 
PubMed Listing

Liu X, Hurt RH, Kane AB. Biodurability of Single-Walled Carbon Nanotubes Depends on Surface Functionalization. Carbon N Y. 
PubMed Listing

2009

Sanchez, V.C., Pietruska, J.R., Miselis, N.R., Hurt, R.H., Kane, A.B. Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos? Nanomed Nanobiotechnol. 
PubMed Listing

2008

Kane, A.B., Hurt, R.H. Nanotoxicology: The Asbestos Analogy Revisited. Nat. Nanotechnol. 
PubMed Listing

Guo, L., Von Dem Bussche, A., Buechner, M., Kane, A.B., Hurt, R.H. Adsorption of essential micronutrients by carbon nanotubes and its implications for nanotoxicity testing. Small, 4(6): 721-7.
PubMed Listing

Liu, X., Guo, L., Morris, D., Kane, A.B., Hurt, R.H. Targeted removal of bioavailable metal as a detoxification strategy for carbon nanotubes. Carbon. 
PubMed Listing

2007

Guo, L., Liu, X., Sanchez, V., Vaslet, C., Kane, A.B., Hurt, R.H. A window of opportunity: Designing carbon nanomaterials for environmental safety and health. Mater. Sci. Forum. 
Online access.

Guo, L., Morris, D.G., Liu, X., Vaslet C., Hurt, R.H., Kane, A.B. Iron bioavailability and redox activity in diverse carbon nanotube samples. Chem. Mater. 
Online access.

Liu, X., Gural, V., Morris, D., Murray, D., Zhitkovich, A., Kane, A.B., Hurt, R.H. Bioavailability of nickel in single-wall carbon nanotubes. Adv. Mater. 
Online access.

Pietruska, J.R., Kane, A.B. SV40 oncoproteins enhance asbestos-induced dna double-strand breaks and abrogate senescence in murine mesothelial cells. Cancer Res. 
PubMed Listing

Yan, A., Von Dem Bussche, A., Kane, A.B., Hurt, R.H. Tocopheryl polyethylene glycol succinate as a safe, antioxidant surfactant for processing carbon nanotubes and fullerenes. Carbon. 
PubMed Listing

2006

Hurt, R.H., Monthioux, M., Kane, A.B. Toxicology of carbon nanomaterials: status, trends, and perspectives on the special issue. Carbon. 
Online access

Yan, A., Lau, B.W., Weissman, B.S., Kulaots, I., Yang, N.Y.C., Kane,A.B., Hurt, R.B. Biocompatible hydrophilic supramolecular carbon nanoparticles for cell delivery. Adv. Mater. 
Online access

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PROJECT 3: Indoor Air Concentration Dynamics and Vapor Intrusion 
Eric M. Suuberg, Sc.D., P.E. 

2016

Shen R and Suuberg EM. (2016). Impacts of changes of indoor air pressure and air exchange rate in vapor intrusion scenarios. Building and Environment, 96: 178-187.

2015

Moradi, Ali, Mazdak Tootkaboni, and Kelly G. Pennell. (2015). A variance decomposition approach to uncertainty quantification and sensitivity analysis of the Johnson and Ettinger model. Journal of the Air & Waste Management Association. 65(2):154-164.
PubMed Listing

Yao Y, Wu Y, Wang Y, Wang JJ, Verginelli I, Zeng Y, Suuberg EM, Jiang L, Wen YZ, Ma J. (2015). A petroleum vapor intrusion model involving upward advective soil gas flow due to methane generation. Environmental Science and Technology, 49(19):11577-85.
PubMed Listing

2014

Shen R, Pennell KG, Suuberg EM (2014). Analytical Modeling of the Subsurface Volatile Organic Vapor Concentration in Vapor Intrusion. Chemosphere, 95: 140-149.
PubMed Listing

Shen R, Suuberg EM (2014). Analytical Quantification of the Subslab Volatile Organic Vapor Concentration from a Non-uniform Source.Environ Model Softw, 54: 1-8.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2014). A Numerical Investigation of Oxygen Concentration Dependence on Biodegradation Rate Laws in Vapor Intrusion. Env Sci Process Impacts, 15(12): 2345-2354.
PubMed Listing

2013

Dannemiller KC, Murphy JS, Dixon SL, Pennell KG, Suuberg EM, Jacobs DE, Sandel M (2013). Formaldehyde concentrations in household air of asthma patients determined using colorimetric detector tubes. Indoor Air 23(4): 285-294.
PubMed Listing

Fu J, Rice JW, Suuberg EM (2013). Phase Behavior and Thermochemical Properties of Polycyclic Aromatic Hydrocarbons and their Derivatives. Handbook of Polycyclic Aromatic Hydrocarbons, G.C. Bandeira and H.E. Meneses, Eds., Nova Science Publishers, Inc., New York, 349-368.

Fu J, Suuberg EM (2013). Thermochemical and Vapor Pressure Behavior of Anthracene and Brominated Anthracene Mixtures. Fluid Phase Equilibria 342: 60-70.
PubMed Listing

Pennell KG, Scammel MK, McClean MD, Ames J, Weldon B, Friguglietti L, Suuberg EM, Shen R, Indeglia PA, Heiger-Bernays WJ (2013). Sewer Gas: An Indoor Air Source of PCE to Consider During Vapor Intrusion Investigations. Ground Water Monitoring & Remediation Summer, 33(3):119-126.
PubMed Listing

Perron M, Burgess RM, Suuberg EM, Cantwell MG, Pennell KG (2013). Performance of Passive Samplers for Monitoring Estuarine Water Column Concentrations: 1. Contaminants of Concern. Environmental Toxicology and Chemistry 32(10: 2182-9.
PubMed Listing

Perron M, Burgess RM, Suuberg EM, Cantwell MG, Pennell KG (2013) Performance of Passive Samplers for Monitoring Estuarine Water Column Concentrations 2. Emerging Contaminants. Environmental Toxicology and Chemistry. 32(10): 2190-6.
PubMed Listing

Rice JW, Fu J, Suuberg EM (2013). Thermodynamics and Phase Behavior of Polycyclic Aromatic Hydrocarbon Mixtures. Handbook of Polycyclic Aromatic Hydrocarbons, G.C. Bandeira and H.E. Meneses, Eds., Nova Science Publishers, Inc., New York, 169-195.

Shen R, Yao Y, Pennell KG, Suuberg EM (2013). Modeling Quantification of the Influence of Soil Moisture on Subslab Vapor Concentration. Environ Sci Process Impacts 15(7): 1444-51.
PubMed Listing

Shen R, Pennell KG, Suuberg EM (2013). Influence of Soil Mosture on Soil Gas Vapor Concentration for Vapor Intrusion. Environ Eng Sci 30(10): 628-637.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2013). Estimation of Contaminant Subslab Concentration in Vapor Intrusion Including Lateral Source–Building Separation. Vadose Zone J 12(3): doi: 10.2136/vzj2012.0157.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2013) Examination of the Influence of Environmental Factors on Contaminant Vapor Concentration Attenuation Factors Using the U.S. EPA's Vapor Intrusion Database. Environ Sci Technol 47(2): 906-913.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2013) Examination of the U.S. EPA's Vapor Intrusion Database Based on Models. Environ Sci Technol 47(3): 1425-33.
PubMed Listing

Yao Y, Pennell KG, Suuberg EM (2013). Simulating the effect of slab features on vapor intrusion of crack entry. Building and Environ 59: 417-425.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2013). A review of vapor intrusion models. Environ Sci Technol, 47(6): 2457-70.
PubMed Listing

2012

Fu J, Rice JW, Suuberg EM (2012) Phase Behavior and Crystal Structure of BinaryPolycyclic Aromatic Compound Mixtures. Crystallization Processes, Y. Mastai, Ed., Intech Publishing, Rijeka, Croatia, 515-538.
Fu, J, Suuberg EM (2012) Thermochemical Properties and Phase Behavior of Halogenated Polycyclic Aromatic Hydrocarbons. Environmental Toxicology and Chemistry 31(3): 488-493.
PubMed Listing

Fu J, Suuberg EM (2012) Vapor Pressure of Three Brominated Flame Retardants Determined via Knudsen Effusion Method. Environmental Toxicology and Chemistry 31(3): 574-578.
PubMed Listing

Shen R, Pennell KG, Suuberg EM (2012) A numerical investigation of vapor intrusion--the dynamic response of contaminant vapors to rainfall events. Sci Total Environ 437: 110-120.
PubMed Listing 

Yao Y, Pennell KG, Suuberg EM (2012) Estimation of contaminant subslab concentration in vapor intrusion. J Hazard Mater 231-232: 10-17.
PubMed Listing 

2011

Fu, J., Suuberg, E.M. Solid Vapor Pressure for five Heavy PAHs via the Knudsen Effusion Method. J. Chemical Thermodynamics.
Online access.

Rice, J.W., Fu, J., Suuberg, E.M. Thermodynamics of Multicomponent PAH Mixtures and Development of Tar-like Behavior. Ind Eng Chem Res. 
PMID: 21442010

Fu, J., Suuberg, E.M. Vapor Pressure of Solid Polybrominated Diphenyl Ethers Determined via Knudsen Effusion Method. Environmental Toxicology and Chemistry. Accepted for publication. 
Suuberg, E.M. Yao, Y., Shen, R., Bozkurt, O., Pennell, K.G. Modeling Vapor Intrusion Processes and Evaluating Risks Using Subslab Data. Environmental Health Risks.
Online access.

Pennell, K. G., Suuberg, E.M. Vapor Transport from Soil and Groundwater: Numerical Modeling Approach. In Vapor Emission to Outdoor Air and Enclosed Spaces for Human Health Risk Assessment, Saponaro, S., Sezenna, E., and Bonomo, L. (Eds.), Nova Science Publishers, New York, pp. 73-90, 2011.

Yao, Y., Pennell, K.G., Suuberg, E.M. Vapor intrusion in urban settings: effect of foundation features and source location. Procedia Environmental Sciences 4, 245-250. 
Online access.

Yao, Y., Shen, R. Pennell, K.G., Suuberg, E.M. Comparison of the Johnson-Ettinger Vapor Intrusion Screening Model Predictions with Full Three-Dimensional Model Results. Environmental Science and Technology 45, 2227-2235. 
PMID: 21344848

Rice, J. Fu, J. Suuberg, E.M. Thermodynamics of Multicomponent PAH Mixtures and Development of Tarlike Behavior. I&EC Research 50, 3613-3620. 
PMID: 21442010

2010

J. Fu, J.W. Rice, E.M. Suuberg. Phase behavior and vapor pressures of the pyrene+9,10-dibromoanthracene system. Fluid Phase Equilibrium, 298, 219-224. 
PMID: 21076624

J.L. Goldfarb and E.M. Suuberg. Deviations from Ideal Sublimation Vapor Pressure Behavior in Mixtures of Polycyclic Aromatic Compounds with Interacting Heteroatoms. Journal of Chemical Thermodynamics, 42, 1009-1015. 

Y. Yao, K.G. Pennell, E.M. Suuberg. The Influence of Transient Processes on Vapor Intrusion Processes. Paper for the AWMA Vapor Intrusion Conference, September 2010. 
Online access.

J.W. Rice and E.M. Suuberg. Thermodynamic Study of (Anthracene plus benzo[a]pyrene) Solid Mixtures. Journal of Chemical Thermodynamics, 42, 1356-1360. 
PMID: 20814451

J.W. Rice, J. Fu, E.M. Suuberg. Anthracene + Pyrene Solid Mixtures: Eutectic and Azeotropic Character. J. Chem. Eng. Data, 55, 3598-3605. 
PMCID: 2992339

J.L. Goldfarb and E.M. Suuberg. Vapor pressures and sublimation enthalpies of seven heteroatomic aromatic hydrocarbons measured via the Knudsen effusion technique. Journal of Chemical Thermodynamics, 42, 781-786. 
PMID: 20414454

2009

R.M. Burgess, M.M. Perron, C.L. Friedman, E.M. Suuberg, K. G. Pennell, M.G. Cantwell, M.C. Pelletier, K.T. Ho, J.R. Serbst, S.A. Ryba. Evaluation of the Effects of Coal Fly Ash Amendments on the Toxicity of a Contaminated Marine Sediment. Env. Toxicology and Chemistry 28, 26-35. 
PMID: 18717615

Bozkurt, O., Pennell, K.G. Suuberg, E.M. Simulation of the Vapor Intrusion Process for Non-Homogeneous Soils Using a Three Dimensional Numerical Model Ground Water Monit Remediat. 
PMID: 20664816

Pennell KG, Bozkurt O, Suuberg EM. Development and Application of a Three-Dimensional Finite Element Vapor Intrusion Model. J Air Waste Manag Assoc. 
PMID: 19418819

Pennell KG and Suuberg EM. Chapter 4: Vapor Transport From Soil and Groundwater: Numerical Modeling Approach. Vapor Emission to Outdoor Air and Enclosed Spaces for Human Health Risk Assessment: Site Characterization, Monitoring and Modeling. Editors: Sabrina Saponaro, Elena Sezenna and Luca Bonomo (Politecnico di Milano, Italy). Nova Science Publishers, Inc. 
Online access.

2008

Goldfarb, J.L., Suuberg, E.M. Raoult's Law and its application to sublimation vapor pressures of mixtures of polycyclic aromatic hydrocarbons . Environ. Eng. Sci. 
Online access

Goldfarb, J.L., Suuberg, E.M. The effects of halogen hetero-atoms on the vapor pressures and thermodynamics of polycyclic aromatic compounds measured via the knudsen effusion technique. J. Chem. Thermodyn. 
PMID: 20376299

Goldfarb, J.L., Suuberg, E.M. Vapor pressures and enthalpies of sublimation of ten polycyclic aromatic hydrocarbons determined via the knudsen effusion method. J. Chem. Eng. Data. 
Online access.

Goldfarb, J.L., Suuberg, E.M. Vapor pressures and thermodynamics of oxygen-containing polycyclic aromatic hydrocarbons measured using knudsen effusion. Environ. Toxicol. Chem. 
PMID: 18220445

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PROJECT 4: Nanomaterial Design for Environmental Health and Safety
Robert Hurt, Ph.D.

2016

Lv XS, Qiu Y, Wang ZY, Jiang GM, Chen YT, Xu XH, Hurt RH (2016). Aerosol synthesis of phase-controlled iron-graphene nanohybrids through FeOOH nanorod intermediates. Enviro. Science: Nano. DOI: 10.1039/C6EN00178E 

Qiu, Y, Felten C, Hurt RH, Külaots, I. (2016). Thermochemistry and kinetics of graphite oxide exothermic decomposition for safety in large-scale storage and processing. Carbon, 96 20-28.

Wang, Z, Zhu W, Qiu Y, Yi X, von dem Bussche A, Kane A, Gao H, Koski K, Hurt RH. Biological and environmental interactions of emerging two-dimensional nanomaterials, Chemical Society Reviews, 45, 1750-1780.
PubMed Listing

Wang Z, von dem Bussche A, Qiu Y, Valentin TM, Gion K, Kane AB, Hurt RH. (2016). Chemical dissolution pathways of MoS2 nanosheets in biological and environmental media. Environmental Science & Technology, 50(13):7208-17.
PubMed Listing

Zhu, Wenpeng, Annette von dem Bussche, Xin Yi, Zhongying Wang, Yang Qiu, Paula Weston, Robert Hurt, Agnes Kane, Huajian Gao.  A nanomechanical model of lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles, (expected 2016) 

 2014

Guo F, Creighton M, Chen Y, Hurt RH, Kulaots I, (2014). Porous structures in stacked, crumpled and pillared graphene-based 3D materials. Carbon, 66: 476–484.
PubMed Listing

Qiu Y, Guo F, Hurt R, Kulaots I (2014). Explosive thermal reduction of graphene oxide-based materials: mechanism and safety implications.  Carbon N Y 72: 215-223. 
PubMed Listing

Qiu Y, Wang Z, Owens AC, Kulaots I, Chen I, Kane AB, Hurt RH. (2014) Antioxidant chemistry of grapheme-based materials and its role in oxidation protection technology. Nanoscale, 6(20): 11744-55.
PubMed Listing

Rodd AL, Creighton MA, Vaslet CA, Rangel-Mendez JR, Hurt RH, Kane AB (2014). Effects of surface-engineered nanoparticle-based dispersants for marine oil spills on the model organism Artemia franciscana. Environ Sci Technol, 48: 6419-6427. 
PubMed Listing

Velazquez LH, Hurt RH, Matos J, Rangel-Mendez JR (2014). Zirconium-carbon hybrid sorbent for removal of fluoride from water: oxalic acid mediated Zr(IV) assembly and adsorption mechanism. Environ Sci Technol 48(2): 1166-1174.
PubMed Listing

2013

Creighton M, Rene Rangel-Mendez J, Huang J, Kane A, Hurt R (2013). Graphene Induced Optical and Adsorptive Artifacts During In Vitro Toxicology Assays. Small 9(11): 1921-1927.
PubMed Listing 

Li Y, Yuan H, von dem Bussche A, Creighton M, Hurt RH, Kane AB, Gao H (2013): Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites. Proc Natl Acad Sci USA 110(30): 12295-300.
PubMed Listing  

Wang Z, von dem Bussche A, Kabadi P, Kane A, Hurt R (2013). Biological and Environmental Transformations of Copper-Based Nanomaterials. ACS Nano 7: 8715-27.
PubMed Listing  

2012

Chen Y, Guo F, Jachak A, Kim SP, Datta D, Liu J, Kulaots I, Vaslet C, Jang HD, Huang J, Kane A, Shenoy VB, Hurt RH. Aerosol synthesis of cargo-filled graphene nanosacks. Nano Lett. 
PubMed listing

Guo F, Silverberg G, Bowers S, Kim SP, Datta D, Shenoy V, Hurt RH. Graphene-based environmental barriers. Environ Sci Technol. 
PubMed listing

Liu J, Katahara J, Li G, Coe-Sullivan S, Hurt RH. Degradation products from consumer nanocomposites: a case study on quantum dot lighting. Environ Sci Technol. 
PubMed listing

Sanchez VC, Jachak A, Hurt RH, Kane AB. Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol. 
PubMed listing

2011

Guo F, Kim F, Han TH, Shenoy VB, Huang J, Hurt RH. Hydration-Responsive Folding and Unfolding in Graphene Oxide Liquid Crystal Phases. ACS Nano. 
PubMed listing

Liu, J., Pennell, K.G., Hurt, R.H. Kinetics and Mechanisms of Nanosilver Oxysulfidation. Environ Sci Technol. 
PubMed listing

Liu, X., Sen, S., Liu, J. , Kulaots, I., Geohegan, D., Kane, A., Puretzkey, A.A., Rouleau, C.M., More, K.L., Palmore, G.T., Hurt, R.H. Antioxidant Deactivation on Graphenic Nanocarbon Surfaces. Small. 
PubMed listing

Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt R, Kane AB. Bioavailability, intracellular mobilization of nickel, and HIF-1a activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci. 
PubMed listing

Sanchez, V.C., Weston, P., Yan, A., Hurt, R.H., Kane, A.B. A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials. Particle and Fibre Toxicology. 
PubMed listing

Shi X, von dem Bussche A, Hurt RH, Kane AB, Gao H. Cell Entry of One-Dimensional Nanomaterials Occurs by Tip Recognition and Rotation. Nat Nanotechnol. 
PubMed listing

2010

Hower, J.C., Senier, C.L., Suuberg, E.M., Hurt, R.H., Wilcox, J.L., Olson, E.S., Mercury capture by native fly ash carbons in coal-fired power plants. Progress in Energy and Combustion Science. 
Online access

Liu, J., Sonshine, D., Shervani, S., Hurt, R.H., Controlled Release of Biological Active Silver from Nanosilver Surfaces. ACS Nano 4(11) 6903–6913 (2010). 
PubMed listing

Liu, X., Hurt, R.H., Kane, A.B. Biodurability of Single-Walled Carbon Nanotubes Depends on Surface Functionalization. Carbon. 
PubMed listing 

2009

Sanchez VC, Pietruska JR, Miselis NR, Hurt RH, Kane AB. Biopersistence and potential adverse health impacts of fibrous nanomaterials: What have we learned from asbestos? Wiley Interdiscip Rev Nanomed Nanobiotechnol. 
PubMed listing

Lee B, Sarin L, Johnson NC, Hurt RH, A nano-selenium reactive barrier approach for managing mercury over the life-cycle of compact fluorescent lamps Environ Sci Technol. 
PubMed listing

Jakubek LM, Marangoudakis S, Raingo J, Liu X, Lipscombe D, Hurt RH. The inhibition of neuronal calcium-ion channels by trace levels of yttrium released from carbon nanotubes, Biomaterials. 
PubMed listing

Liu X, Vinson D, Abt D, Hurt RH, Rand DM. Differential toxicity of carbon nanomaterials in Drosophila: Larval dietary uptake is benign but adult exposure causes locomotor impairment and mortality. Environ Sci Technol. 
PubMed listing

2008

Johnson, N., Manchester, S., Sarin, L., Gao, Y., Kulaots, I., Hurt, R.H. Mercury vapor release from broken compact fluorescent lamps and in situ capture by new nanomaterial sorbents. Environ Sci Technol. 
PubMed listing

Guo L, Von Dem Bussche A, Buechner M, Yan A, Kane AB, Hurt RH. Adsorption of essential micronutrients by carbon nanotubes and its implications for nanotoxicity testing. Small. 
PubMed listing

Liu, X., Guo, L., Morris, D., Kane, A., Hurt, R.H. Targeted Removal of Bioavailable Metal as a Detoxification Strategy for Carbon Nanotubes. Carbon. 
PubMed listing

Manchester, S., Wang, X., Kulaots, I., Gao, Y., Hurt, R.H. High capacity mercury adsorption on freshly ozone-treated carbon surfaces. Carbon. 
PubMed listing

2007

Guo, L., Liu, X., Sanchez, V., Vaslet, C., Kane, A.B., Hurt, R.H. A window of opportunity: Designing carbon nanomaterials for environmental safety and health. Mater. Sci. Forum. 
Online access

Guo, L., Morris, D.G., Liu, X., Vaslet C., Hurt, R.H., Kane, A.B. Iron bioavailability and redox activity in diverse carbon nanotube samples. Chem. Mater. 
Online access

Jian, K., Truong, T.C., Hoffman, W.P., Hurt, R.H. Mesoporous carbons with self-assembled surfaces of defined crystal orientation. Microporous Mesoporous Mater. 
PubMed listing

Liu, X., Gural, V., Morris, D., Murray, D., Zhitkovich, A., Kane, A.B., Hurt, R.H.G Bioavailability of nickel in single-wall carbon nanotubes. Adv. Mater. Online access

Yan, A., Von Dem Bussche, A., Kane, A.B., Hurt, R.H. Tocopheryl polyethylene glycol succinate as a safe, antioxidant surfactant for processing carbon nanotubes and fullerenes. Carbon. 
PubMed listing 

2006

Hurt, R.H., Monthioux, M., Kane, A.B. Toxicology of carbon nanomaterials: status, trends, and perspectives on the special issue. Carbon. 
Online access

Yan, A., Lau, B.W., Weissman, B.S., Kulaots, I., Yang, N.Y.C., Kane,A.B., Hurt, R.B. Biocompatible hydrophilic supramolecular carbon nanoparticles for cell delivery. Adv. Mater. 
Online access

Jian K, Kulaots I, Yan A, Crawford GP, Hurt, R.H. Reconstruction and hydrophobicity of nanocarbon surfaces composed solely of graphene edges. Carbon. 
Online access

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CORE 2: Research Translation Core 
Eric M. Suuberg, Sc.D., P.E. 

2014

Shen R, Pennell KG, Suuberg EM (2014). Analytical Modeling of the Subsurface Volatile Organic Vapor Concentration in Vapor Intrusion. Chemosphere, 95: 140-149.
PubMed Listing

Shen R, Suuberg EM (2014). Analytical Quantification of the Subslab Volatile Organic Vapor Concentration from a Non-uniform Source. Environ Model Softw, 54: 1-8.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2014). A Numerical Investigation of Oxygen Concentration Dependence on Biodegradation Rate Laws in Vapor Intrusion. Env Sci Process Impacts, 15(12): 2345-2354.
PubMed Listing 

2013

Pennell KG, Thompson M, Rice JW, Senier L, Brown P, Suuberg EM (2013). Bridging Research and Environmental Regulatory Processes: The Role of Knowledge Brokers. Environ Sci Technol, 47(21): 11985-92.
PubMed Listing

Pennell KG, Scammel MK, McClean MD, Ames J, Weldon B, Friguglietti L, Suuberg EM, Shen R, Indeglia PA, Heiger-Bernays WJ (2013). Sewer Gas: An Indoor Air Source of PCE to Consider During Vapor Intrusion Investigations. Ground Water Monitoring & Remediation Summer, 33(3):119-126.
PubMed Listing

Perron M, Burgess RM, Suuberg EM, Cantwell MG, Pennell KG (2013). Performance of Passive Samplers for Monitoring Estuarine Water Column Concentrations: 1. Contaminants of Concern. Environmental Toxicology and Chemistry. 32(10): 2182-9.
PubMed Listing

Perron M, Burgess RM, Suuberg EM, Cantwell MG, Pennell KG (2013) Performance of Passive Samplers for Monitoring Estuarine Water Column Concentrations 2. Emerging Contaminants. Environmental Toxicology and Chemistry. 32(10): 2190-6.
PubMed Listing

Shen R, Pennell KG, Suuberg EM (2013). Influence of Soil Mosture on Soil Gas Vapor Concentration for Vapor Intrusion. Environ Eng Sci, 30(10): 628-637.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2013). Estimation of Contaminant Subslab Concentration in Vapor Intrusion Including Lateral Source–Building Separation. Vadose Zone J 12(3): doi: 10.2136/vzj2012.0157.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2013) Examination of the Influence of Environmental Factors on Contaminant Vapor Concentration Attenuation Factors Using the U.S. EPA's Vapor Intrusion Database. Environ Sci Technol 47(2): 906-913.
PubMed Listing 

Yao Y, Shen R, Pennell KG, Suuberg EM (2013) Examination of the U.S. EPA's Vapor Intrusion Database Based on Models. Environ Sci Technol 47(3): 1425-33.
PubMed Listing

Yao Y, Pennell KG, Suuberg EM (2013). Simulating the effect of slab features on vapor intrusion of crack entry. Building and Environ 59: 417-425.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2013). A review of vapor intrusion models. Environ Sci Technol, 47(6): 2457-70.
PubMed Listing

2012

Thompson M, Rice J, and Suuberg, EM. Superfund Research Program. (2012). EnviroMentor, 12, 6-8. (Not Peer Reviewed).

2010

Hower JC, Senier CL, Suuberg EM, Hurt RH, Wilcox JL, Olson ES (2010) Mercury capture by native fly ash carbons in coal-fired power plants. Progress in Energy and Combustion Science, 36(4), 510–529.
PubMed Listing

2007

Bozkurt, O., Pennell, K.G., Suuberg, E.M. Evaluation of characterization techniques for vapor intrusion sites using a three-dimensional computational fluid dynamics (CFD) model. AWMA Vapor Intrusion Conference Proceedings Preprints, 2007.

Bozkurt, O., Pennell, K.G., Suuberg, E.M. Evaluation of vapor intrusion potential using a three-dimensional computational fluid dynamics (CFD) Model. Am. Chem. Soc. Environ. Chem. Div. Preprints, 2007.

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CORE 3: Community Engagement Core
Scott Frickel, Ph.D.

2014

Thompson MR, Burdon A, Boekelheide K (2014). Practice-based evidence informs environmental health policy and regulation: A case study of residential lead-soil contamination in Rhode Island. Sci Total Environ, 468–469, 514–522.
PubMed Listing 

2013

Pennell KG, Thompson M, Rice JW, Senier L, Brown P, Suuberg EM (2013). Bridging Research and Environmental Regulatory Processes: The Role of Knowledge Brokers. Environ Sci Technol, 47(21), 11985-92.
PubMed Listing 

Thompson MR, Boekelheide K (2013). Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999–2004): Body burden and risk factors. Env Res, 121, 23-30.
PubMed Listing 

2012

Cordner A, Ciplet D, Morello-Frosch R, Brown P (2012) Reflexive Research Ethics for Environmental Health and Justice. Soc Mov Stud. 11(2): 161-176. 
PubMed Listing 

2011

Cohen, A. K., Waters, A., Brown, P. Place-based Environmental Health Justice Education: A Community-University-Government-Middle School Partnership. Environmental Justice, in press.

2010

Cohen, A. Achieving Healthy School Siting and Planning Policies: Understanding Shared Concerns of Environmental Planners, Public Health Professionals, and Educators. New Solutions, 20(1), 49-72. 
Available online.

2008

Brown, P., Senier. L. Environmental Sociologists Help Form Local Environmental Justice Organization. Environment and Technology Section Newsletter (American Sociological Association), 2008. (Not peer reviewed.)

Senier, L., Hudson, B., Fort, S., Hoover, E., Tillson, R., Brown, P. The Brown Superfund Basic Research Program: A Multistakeholder Partnership Addresses Real-World Problems in Contaminated Communities. Environ. Sci. Technol. 
PMID: 18677987

2007

Brown, P. Toxic Exposures: Contested Illnesses and the Environmental Health Movement. Columbia University Press, 2007.

2006

Senier, L., Altman, R., Morello-Frosch, R., Brown, P. "Research and Action for Environmental Health and Environmental Justice: A Report on the Brown University Contested Illnesses Research Group." (Collective Behavior and Social Movements Newsletter (American Sociological Association), 2006. (Not peer reviewed.)

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CORE 4: Molecular Pathology Core 
Robbert Creton, Ph.D.

2015

Kabadi PK, Vantangoli MM, Rodd AL, Leary E, Madnick SJ, Morgan JR, Kane, AB, Boekelheide, K. 2015. Into the depths: Techniques for in vitro three-dimensional microtissue visualization. Biotechniques. 1:59(5):279-86.
PubMed Listing

2013

Kalkunte S, Neubeck S, Norris WE, Cheng S, Kostadinov S, Hoang DV, Ahmed A, Eggeling F, Shaikh Z, Padbury J, Berg G, Olofsson A, Markert UR, Sharma S (2013). Transthyretin is dysregulated in preeclampsia and its native form prevents the onset of disease in a preclinical mouse model. Am J Pathol, 183(5), 1425-36.
PubMed Listing

Li Y, Yuan H, von dem Bussche A, Creighton M, Hurt RH, Kane AB, Gao H (2013). Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites. Proc Natl Acad Sci USA ,110, 12295-12300.
PubMed Listing

Richendrfer H, Creton R (2013). Automated high-throughput behavioral analyses in zebrafish larvae. J Vis Exp, (77), e50622. doi: 10.3791/50622.
PubMed Listing

Thaxton J, Saito S, Sharma S (2013). NKG2D Blockade Inhibits Poly(I:C)-Triggered Fetal Loss in Wild Type but Not IL-10-/- Mice. J Immunol, 90(7), 3639-47.
PubMed Listing

2012

Campion SN, Catlin N, Houseman EA, Hensley J, Sui Y, Gaido KW, Wu Z, Boekelheide K (2012). Molecular Alterations Underlying the Enhanced Disruption of Spermatogenesis by 2,5-Hexanedione and Carbendazim Co-exposure. Reprod Toxicol, 33(3), 382-9.
PubMed Listing

Chen Y, Guo F, Jachak A, Kim SP, Datta D, Liu J, Kulaots I, Vaslet C, Jang HD, Huang J, Kane A, Shenoy VB, Hurt RH (2012). Aerosol synthesis of cargo-filled graphene nanosacks. Nano Lett, 12(4), 1996–2002.
PubMed Listing

Pacheco SE, Anderson LM, Sandrof MA, Vantangoli MM, Hall SJ, Boekelheide K (2012). Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat. PLoS ONE, 7(8), e44280.
PubMed Listing

Springer C, Dere E, Hall SJ, McDonnell-Clark E, Roberts SC, Butt CM, Stapleton HM, Watkins DJ, McClean MD, Webster TF, Schlezinger JJ, Boekelheide K (2012). Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (TBPH), a novel brominated flame retardant present in indoor dust. Environ Health Perspect, 120(12), 1711–1719.
PubMed Listing

Sanchez V, Jachak A, Hurt, RH, Kane AB (2012) Biological interactions of graphene-family nanomaterials: An interdisciplinary review. Chem Res Toxicol, 25(1), 15-34.
PubMed Listing

2011

Lai Z, Kalkunte S, Sharma S (2011). A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice. Hypertension 57(3), 505-14.
PubMed Listing

Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt R, Kane AB (2011). Bioavailability, intracellular mobilization of nickel, and HIF-1? activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci, 124(1), 138-48.
PubMed Listing

Sanchez, VC, Weston P, Yan A, Hurt RH, Kane AB (2011). A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials. Particle and Fibre Toxicology, 8,17.
PubMed Listing

Shi X, von dem Bussche A, Hurt RH, Kane AB, Gao H (2011). Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation. Nat Nanotechnol, 6(11), 714-9.
PubMed Listing

2010

Campion SN, Houseman EA, Sandrof MA, Hensley J, Sui Y, Gaido KW, Wu Z, Boekelheide K (2010). Suppression of Radiation-induced Testicular Germ Cell Apoptosis. II. Gene Array Analysis Reveals Adaptive Changes in Cell Cycle and Cell Death Pathways. Toxicol Sci, 117(2), 457-65.
PubMed Listing

Campion SN, Sandrof MA, Yamasaki H, Boekelheide K (2010). Suppression of Radiation-induced Testicular Germ Cell Apoptosis. III. Candidate Gene Analysis Identifies a Role for Fas in the Attenuation of X-ray-induced apoptosis. Toxicol Sci, 117(2), 466-74.
PubMed Listing

Kalkunte S, Boij R, Norris W, Friedman J, Lai Z, Kurtis J, Ham KH, Padbury J, Matthiesen L, Sharma S (2010). Sera from preeclampsia patients elicit symptoms of human disease in mice and provide a basis for an in vitro predictive assay. Am J Pathol, 77(5), 2387-98.
PubMed Listing

Lau BW, Kane AB (2010). SDF1/CXCL12 is involved in recruitment of stem-like progenitor cells to orthotopic murine malignant mesothelioma spheroids. Anticancer Res, 30(6), 2153-60.
PubMed Listing

Liu X, Hurt RH, Kane AB (2010). Biodurability of Single-Walled Carbon Nanotubes Depends on Surface Functionalization. Carbon, NY, 48(7), 1961-1969.
PubMed Listing

Pietruska JR, Johnston T, Zhitkovich A, Kane AB (2010). XRCC1 Deficiency Sensitizes Human Lung Epithelial Cells to Genotoxicity by Crocidolite Asbestos and Libby Amphibole. Environ Health Perspect, 118(12), 1707-13.
PubMed Listing

Yamasaki H, Sandrof MA, Boekelheide K (2010). Suppression of Radiation-induced Testicular Germ Cell Apoptosis by 2,5-Hexanedione Pretreatment. I. Histopathological Analysis Reveals Stage-Dependence of Attenuated Apoptosis. Toxicol Sci, 117(2), 449-56.
PubMed Listing

2009

Kalkunte S, Lai Z, Norris W, Pietras L, Tewari N, Boij R, Neubeck S, Markert U, Sharma S (2009). Novel approaches for mechanistic understanding and predicting preeclampsia. J Reprod Immunol, 83(1-2), 134-8.
PubMed Listing

McGowan EC, Kostadinov S, McLean K, Venturini D, Romero R, Laptook AR, Sharma S (2009). Placental IL-10 dysregulation and association with bronchopulmonary dysplasia risk. Pediatric Res, 66(4), 455-60.
PubMed Listing

Murphy S, Hanna NN, Fast L, Shaw SK, Berg G, Padbury G, Romero R, and Sharma S (2009). Evidence for participation of uterine natural killer cells in the mechanisms responsible for spontaneous preterm labor and delivery. Am J Obstet Gynecol, 200(3), 308.
PubMed Listing

Tewari N, Kalkunte S, Murray D, Sharma S (2009). The water channel aquaporin 1 is a novel molecular target of polychlorinated biphenyls for in utero anomalies. J. Biol. Chem, 284(22), 15224-32.
PubMed Listing

Thaxton, JE, Romero, R, Sharma S (2009). TLR-9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. J Immunol, 183(2), 1144-54. 
PubMed Listing

[Return to Top]

 CORE 5: Training Core 
Agnes Kane, M.D., Ph.D.

2014

Catlin N, Huse SM, Boekelheide K (2014). The stage-specific testicular germ cell apoptotic response to low dose x-irradiation and 2,5-hexanedione combined exposure. I. Validation of the laser capture microdissection method for qRT-PCR array application. Toxicol Pathol, 42:1221-1228. 
PubMed Listing

Catlin N, Huse SM, Boekelheide K. (2014). The stage-specific testicular germ cell apoptotic response to low dose x-irradiation and 2,5-hexanedione combined exposure. II. qRT-PCR array analysis reveals dose dependent adaptive alterations in the apoptotic pathway. Toxicol Pathol, 42:1229-1237.
PubMed Listing

Guo F, Creighton M, Chen Y, Hurt RH, Kulaots I, (2014). Porous structures in stacked, crumpled and pillared graphene-based 3D materials. Carbon, 66: 476–484.
PubMed Listing

Qiu Y, Guo F, Hurt R, Kulaots I (2014). Explosive thermal reduction of graphene oxide-based materials: mechanism and safety implications.  Carbon N Y 72: 215-223. 
PubMed Listing

Qiu Y, Wang Z, Owens AC, Kulaots I, Chen I, Kane AB, Hurt RH. (2014) Antioxidant chemistry of grapheme-based materials and its role in oxidation protection technology. Nanoscale, 6(20): 11744-55. 
PubMed Listing 

Rider C, Boekelheide K, Catlin N, Gordon C, Morata T, Sexton K, Simmons J (2014). Cumulative Risk: Toxicity and Interactions of Physical and Chemical Stressors. Toxicol Sci, 137: 3-11.
PubMed Listing

Rodd AL, Creighton MA, Vaslet CA, Rangel-Mendez JR, Hurt RH, Kane AB (2014). Effects of surface-engineered nanoparticle-based dispersants for marine oil spills on the model organism Artemiafranciscana. Environ Sci Technol, 48: 6419-6427. 
PubMed Listing 

Shen R, Pennell KG, Suuberg EM (2014). Analytical Modeling of the Subsurface Volatile Organic Vapor Concentration in Vapor Intrusion. Chemosphere, 95: 140-149. 
PubMed Listing

Shen R, Suuberg EM (2014). Analytical Quantification of the Subslab Volatile Organic Vapor Concentration from a Non-uniform Source.Environ Model Softw, 54: 1-8.
PubMed Listing

Thompson MR, Burdon A, Boekelheide K (2014). Practice-based evidence informs environmental health policy and regulation: A case study of residential lead-soil contamination in Rhode Island. Sci Total Environ, 468–469: 514–522.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2014). A Numerical Investigation of Oxygen Concentration Dependence on Biodegradation Rate Laws in Vapor Intrusion. Env Sci Process Impacts, 15(12): 2345-2354.
PubMed Listing 

2013

Creighton M, Rene Rangel-Mendez J, Huang J, Kane A, Hurt R (2013). Graphene Induced Optical and Adsorptive Artifacts During In Vitro Toxicology Assays. Small, 9(11): 1921-1927. 
PubMed Listing

Dannemiller KC, Murphy JS, Dixon SL, Pennell KG, Suuberg EM, Jacobs DE, Sandel M (2013). Formaldehyde concentrations in household air of asthma patients determined using colorimetric detector tubes. Indoor Air, 23(4): 285-294. 
PubMed Listing

Perron M, Burgess RM, Suuberg EM, Cantwell MG, Pennell KG (2013). Performance of Passive Samplers for Monitoring Estuarine Water Column Concentrations: 1. Contaminants of Concern. Environ Toxicol Chem 32(10): 2182-9.
PubMed Listing

Perron M, Burgess RM, Suuberg EM, Cantwell MG, Pennell KG (2013) Performance of Passive Samplers for Monitoring Estuarine Water Column Concentrations 2. Emerging Contaminants.  Environ Toxicol Chem 32(10):  2190-6. 
PubMed Listing

Thaxton J, Saito S, Sharma S (2013). NKG2D Blockade Inhibits Poly(I:C)-Triggered Fetal Loss in Wild Type but Not IL-10-/- Mice. J Immunol, 90(7): 3639-47.
PubMed Listing

Thompson MR, Boekelheide K (2013). Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999–2004): Body burden and risk factors. Env Res, 121: 23-30.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2013). Examination of the Influence of Environmental Factors on Contaminant Vapor Concentration Attenuation Factors Using the U.S. EPA's Vapor Intrusion Database. Environ Sci Technol, 47(2): 906-913. 
PubMed Listing 

Yao Y, Shen R, Pennell KG, Suuberg EM (2013). Examination of the U.S. EPA's Vapor Intrusion Database Based on Models. Environ Sci Technol, 47(3): 1425-33.
PubMed Listing

Yao Y, Pennell KG, Suuberg EM (2013). Simulating the effect of slab features on vapor intrusion of crack entry. Building and Environ, 59: 417-425.
PubMed Listing

Yao Y, Shen R, Pennell KG, Suuberg EM (2013). Estimation of Contaminant Subslab Concentration in Vapor Intrusion Including Lateral Source–Building Separation. Vadose Zone J 12(3).
PubMed Listing

2012

Calo JM, Madhavan L, Kirchner J, Bain EJ (2012). Arsenic Removal Via ZVI in a Hybrid Spouted Vessel/Fixed Bed Filter System. Chem Eng J, 189–190: 237–243.
PubMed Listing

Campion SN, Catlin N, Houseman EA, Hensley J, Sui Y, Gaido KW, Wu Z, Boekelheide K (2012). Molecular Alterations Underlying the Enhanced Disruption of Spermatogenesis by 2,5-Hexanedione and Carbendazim Co-exposure. Reprod Toxicol, 33(3): 382-9.
PubMed Listing

Chen Y, Guo F, Jachak A, Kim SP, Datta D, Liu J, Kulaotos I, Vaslet C, Jang HD, Huang J, Kane A, Shenoy VB, Hurt RH (2012). Aerosol synthesis of cargo-filled graphene nanosacks. Nano Lett, 12(4): 1996-2002.
PubMed Listing

Fu J, Suuberg EM (2012). Vapor Pressure of Three Brominated Flame Retardants Determined via Knudsen Effusion Method. Environmental Toxicology and Chemistry, 31(3): 574-578.
PubMed Listing

Houseman EA, Accomando WP, Koestler DC, Christensen BC, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT (2012). DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics, 13: 86.
PubMed Listing

Jachak A, Creighton M, Qiu Y, Kane AB, Hurt RH (2012). Biological Interactions and Safety of Graphene Materials. MRS Bulletin 37(12): 1307-1313.
PubMed Listing

Lambertini L, Marsit CJ, Sharma P, Maccani M, Ma Y, Hu J, Chen J (2012). Imprinted gene expression in fetal growth and development. Placenta, 33(6): 480-6.
PubMed Listing

Langevin SM, Koestler DC, Christensen BC, Butler RA, Wiencke JK, Nelson HH, Houseman EA, Marsit CJ, Kelsey KT (2012). Peripheral blood DNA methylation profiles are indicative of head and neck squanmous cell carcinoma: an epigenome-wide association study. Epigenetics, 7(3): 291-9.
PubMed Listing

Liu J, Wang Z, Liu FD, Kane AB, Hurt RH (2012). Chemical Transformations of Nanosilver in Biological Environments. ACS Nano, 6(11): 9887-99.
PubMed Listing

Springer C, Dere E, Hall SJ, McDonnell-Clark E, Roberts SC, Butt CM, Stapleton HM, Watkins DJ, McClean MD, Webster TF, Schlezinger JJ, Boekelheide K (2012). Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (TBPH): a novel brominated flame retardant present in indoor dust. Environ Health Perspect, 120: 1711-1719.
PubMed Listing

Maccani MA, Marsit CJ (2011). Exposure and fetal growth-associated miRNA alterations in the human placenta. Clin Epigenetics, 2(2): 401-4.
PubMed Listing

Marsit CJ, Maccani MA, Padbury JF, Lester BM (2012). Placental 11-beta hydroxysteriod degydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome. PLoS One, 7(3): e33794.
PubMed Listing

Marsit CJ, Lambertini L, Maccani MA, Koestler DC, Houseman EA, Padbury JF, Lester BM, Chen J (2012). Placenta-imprinted gene expression association of infant neurobehavior. J Pediatr, 160(5): 854-860.
PubMed Listing

Pacheco SE, Anderson LM, Boekelheide K (2012). Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting. J Androl, 33(5): 811-6.
PubMed Listing

Pacheco SE, Anderson LM, Sandrof MA, Vantangoli MM, Hall SJ, Boekelheide K (2012). Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat. PLoS ONE, 7(8): e44280.
PubMed Listing

Sanchez V, Jachak A, Hurt, RH, Kane AB (2012). Biological interactions of graphene-family nanomaterials: An interdisciplinary review. Chem Res Toxicol, 25(1): 15-34.
PubMed Listing

Shen R, Pennell KG, Suuberg EM (2012). A numerical investigation of vapor intrusion--the dynamic response of contaminant vapors to rainfall events. Sci Total Environ, 437: 110-120.
PubMed Listing

Thompson MR (2012). Mercury Contamination: Analysis of a residential response. Professional safety, 57(2): 50-58.
PubMed Listing

Wilhelm-Benartzi CS, Houseman EA, Maccani M, Poage G, Koestler DC, Langevin SM, Gagne, L, Banister, C, Padbury, JP, Marsit, CJ (2012). In Utero Exposures, Infant Growth, and DNA Methylation of Repetitive Elements and Developmentally Related Genes in Human Placenta. Environ Health Perspect, 120(2): 296–302. 
PubMed Listing

Yao Y, Pennell KG, Suuberg EM (2012). Estimation of contaminant subslab concentration in vapor intrusion. J Hazard Mater, 231-232: 10-17.
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2011

Banister CE, Koestler DC, Maccani M, Padbury JF, Houseman EA, Marsit CJ (2011). Infant Growth Restriction is Associated with Distinct Patterns of DNA Methylation in Human Placentas. Epigenetics, 6(7): 920-7.
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Brown P, Zavestoski S, McCormick S, Mayer B, Morello-Frosch R, Altman R, Adams C, Hoover E (2011). Embodied Health Movements: Uncharted Territory in Social Movement Research. In Contested Illnesses: Ethnographic Explorations. Edited by Phil Brown, Rachel Morello-Frosch, and Stephen Zavestoski. University of California Press.

Filiberto AC, Maccani MA, Wilhelm C, Gagne LA, Marsit CJ (2011). Birthweight is Associated with DNA Promoter Methylation of the Glucocorticoid Receptor in Human Placenta. Epigenetics, 6(5): 566-72.
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Fu J, Suuberg EM (2011). Solid Vapor Pressure for five Heavy PAHs via the Knudsen Effusion Method.  J Chemical Thermodynamics, 43(11): 1660-1665.
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Lai Z, Kalkunte S, Sharma S (2011). A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice. Hypertension, 57(3): 505-14.
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Liu X, Sen S, Liu J, Kulaots I, Geohegan D, Kane A, Puretzkey AA, Rouleau CM, More KL, Palmore GT, Hurt RH (2011). Antioxidant Deactivation on Graphenic Nanocarbon Surfaces. Small, 7(19): 2775-85.
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Liu J, Pennell KG, Hurt RH (2011). Kinetics and Mechanisms of Nanosilver Oxysulfidation. Environ Sci Technol, 45(17): 7345-53.
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Maccani MA, Padbury JF, Marsit, CJ (2011). miR-16 and miR-21 expression in the placenta is associated with fetal growth. PLoS One, 6(6): e21210.
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Marsit CJ, Koestler DC, Christensen BC, Karagas MR, Houseman EA, Kelsey KT (2011). DNA methylation array analysis identifies profiles of blood-derived DNA methlyation associated with bladder cancer. J Clin Oncol, 29(9): 1133-9.
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Pacheco SE, Houseman EA, Christensen BC, Marsit CJ, Kelsey KT, Sigman M, Boekelheide K (2011). Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm. PLoS ONE, 6(6): e20280.
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Pennell KG, Suuberg EM (2011). Vapor Transport from Soil and Groundwater: Numerical Modeling Approach. In Vapor Emission to Outdoor Air and Enclosed Spaces for Human Health Risk Assessment, S. Saponaro, E. Sezenna, L. Bonomo, Eds., Nova Science Publishers, Hauppauge, NY, 73-90.

Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt RH, Kane AB (2011). Bioavailability, intracellular mobilization of nickel and HIF-1? Activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci, 124(1): 138-48.
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Rice JW, Fu J, Suuberg EM (2011). Thermodynamics of Multicomponent PAH Mixtures and Development of Tarlike Behavior. I&EC Research, 50(6): 3613-3620.
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Sanchez VC, Weston P, Yan A, Hurt RH, Kane AB (2011). A 3-dimensional in vitro model of epithelioid granulomas induced by high aspect ratio nanomaterials. Particle and Fibre Toxicology, 8, 17.
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Wilhelm-Benartzi CS, Christensen BC, Koestler DC, Andres Houseman E, Schned AR, Karagas MR, Kelsey KT, Marsit CJ (2011). Association of secondhand smoke exposures with DNA methylation in bladder carcinomas. Cancer Causes Control, 22(8): 1205-12.
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Yao Y, Shen R, Pennell KG, Suuberg EM (2011). Comparison of the Johnson- Ettinger Vapor Intrusion Screening Model Predictions with Full Three-Dimensional Model Results. Environmental Science and Technology, 45(6): 2227-2235.
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Yao Y, Pennell KG, Suuberg EM (2011). Vapor intrusion in urban settings: effect of foundation features and source location. Procedia Environmental Sciences, 4, 245-250.
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2010

Avissar M, Veiga K, Uhl K, Moen E, Maccani M, Gagne L, Marsit CJ (2010). Bisphenol A Exposure Leads to MicroRNA Alterations in Placental Cells. Reprod Toxicol, 29(4): 401-6.
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Bain EJ, Calo JM, Spitz-Steinberg R, Kirchner J, Axen J (2010). Electrosorption/electrodesorption of arsenic on a granular activated carbon in the presence of other heavy metals. Energy Fuels, 24(6): 3415-3421.
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Boekelheide K, Campion SN (2010). Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects. Toxicol Sci, 114(1): 20-4.
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Brown P, Morello-Frosch R, Zavestoski S, Senier L, Altman R, Hoover E, McCormick S, Mayer B, Adams C (2010) Field Analysis and Policy Ethnography: New Directions for Studying Health Social Movements. In Social Movements and the Transformation of American Health Care. Edited by Mayer Zald, Jane Banaszak-Holl, and Sandra Levitsky. Oxford University Press. P. 101-116.

Brown P, Morello-Frosch R, Zavestoski S, Senier L, Altman R, Hoover E, McCormick S, Mayer B, Adams C (2010) Health Social Movements: Advancing Traditional Medical Sociology Concepts. In Handbook of Health, Illness & Healing: Blueprint for the 21st Century. Edited by Bernice A. Pescosolido, Jack K. Martin, Jane McLeod, and Anne Rogers, New York: Springer. P. 117-138.

Campion SN, Houseman EA, Sandrof MA, Hensley J, Sui Y, Gaido KW, Wu Z, Boekelheide K (2010). Suppression of Radiation-induced Testicular Germ Cell Apoptosis. II. Gene Array Analysis Reveals Adaptive Changes in Cell Cycle and Cell Death Pathways. Toxicol Sci, 117(2): 457-65.
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Campion SN, Sandrof MA, Yamasaki H, Boekelheide K (2010). Suppression of Radiation-induced Testicular Germ Cell Apoptosis. III. Candidate Gene Analysis Identifies a Role for Fas in the Attenuation of X-ray-induced apoptosis. Toxicol Sci, 117(2): 466-74.
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Fu J,  Rice JW, Suuberg EM (2010). Phase behavior and vapor pressures of the pyrene+9,10- dibromoanthracene system. Fluid Phase Equilibrium, 298(2): 219-224.
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Goldfarb JL, Suuberg EM (2010). Vapor pressures and sublimation enthalpies of seven heteroatomic aromatic hydrocarbons measured via the Knudsen effusion technique. Journal of Chemical Thermodynamics, 42(6): 781-786.
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Koestler DC, Christensen BC, Karagas MR, Bueno R, Sugarbaker DJ, Kelsey KT, Marsit CJ, Houseman EA (2010). Semi-Supervised Recursively Partitioned Mixture Models for Identifying Cancer Subtypes. Bioinformatics, 26(20): 2578-85.
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Liu X, Hurt RH, Kane AB (2010) Biodurability of Single-Walled Carbon Nanotubes Depends on Surface Functionalization. Carbon NY, 48(7): 1961-1969.
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Maccani MA, Avissar-Whiting M, Banister CE, McGonnigal B, Padbury JF, Marsit CJ (2010). Maternal Cigarette Smoking During Pregnancy is Associated with Downregulation of miR-16, miR-21, and miR-146a in the Placenta. Epigenetics, 5(7): 583-9.
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Pietruska JR, Johnston T, Zhitkovich A, Kane AB (2010). XRCC1 Deficiency Sensitizes Human Lung Epithelial Cells to Genotoxicity by Crocidolite Asbestos and Libby Amphibole. Environ Health Perspect,118(12): 1707-13.
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Rice JW, Fu J, Suuberg EM (2010). Anthracene + Pyrene Solid Mixtures: Eutectic and Azeotropic Character. J Chem Eng Data, 55(9): 3598-3605.
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Rice JW, Suuberg EM (2010). Thermodynamic Study of (Anthracene plus benzo[a]pyrene) Solid Mixtures.Journal of Chemical Thermodynamics, 42(11): 1356-1360.
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Wilhelm-Benzarti CS, Koestler DC, Houseman EA, Christensen BC, Wiencke JK, Schned AR, Karagas MR, Kelsey KT, Marsit CJ (2010). DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis, 31(11): 1972-6.
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2009

Liu X, Abt D., Vinson, D., Hurt, RH., Rand, D. Differential toxicity of carbon nanomaterials in Drosophilia: Larval dietary uptake in benign but adult exposure causes locomotor impairment and mortality. Environ. Sci. Technol. 
PMID: 19746737

Jakubek L, Marangoudakis S, Raingo J, Liu X, Lipscombe D, Hurt RH. The inhibition of neuronal calcium-ion channels by trace levels of yttrium released from carbon nanotubes. Biomaterials. 
PMID: 19698989

Hoover E, Brown P, Averick M, Kane A and Hurt R. Teaching small and thinking large: Effects of including social and ethical implications in an interdisciplinary nanotechnology course. Journal of Nano Education. 
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