Collaborating Labs

The following laboratories collaborate with one of the zebrafish groups at Brown University.  These laboratories may study cell lines, invertebrate organisms, rodent models or human tissues and use zebrafish as a complementary model system.

The laboratory of Dr. Rachel Altura
Department of Pediatrics
The Warren Alpert Medical School at Brown University

Our laboratory is exploring novel anti-cancer treatments for pediatric and adult malignancies. We are also interested in the toxicities of chemotherapy and on whether mutations in specific genes make children more prone to develop toxicity after chemotherapy treatment.

* In May 2014, Dr. Altura joined the division of Discovery Medicine Oncology, Bristol-Myers Squibb, Lawrenceville, NJ.  Dr. Altura continues to work on her research program at Brown University as an adjunct professor in collaboration with Dr. DeNardo and Dr. Chalwa. 

Link to faculty profile:

People in the Altura Lab who use zebrafish as a model system:

Rachel Altura (PI), Email:
Mike Holloway (Assistant Professor), Email:
Bradley Denardo (Postdoc), Email:
Kevin Nguyen (Undergraduate Student), Email:
Colby Davis (Undergraduate Student), Email:
Isabela Souza (Undergraduate Student), Email:

The laboratory of Dr. Richard Bennett
Department of Molecular Microbiology & Immunology
Brown University

My laboratory is interested in understanding the biology of the human pathogen Candida albicans. C. albicans is a yeast that grows in the human gastrointestinal tract and is usually harmless to humans. However, in some cases, Candida can cause localized infections in healthy individuals and even life-threatening systemic (bloodstream) infections in immunocompromised individuals. The focus of the laboratory is to understand how Candida acts as a pathogen in humans.

Link to faculty profile: 
Link to Bennett laboratory:

People in the Bennett Lab who use zebrafish as a model system:

Richard Bennett (PI), Email:
Emily Mallick (Graduate Student), Email:

The laboratory of Dr. Elizabeth Brainerd
Department of Ecology and Evolutionary Biology
Brown University

Professor Brainerd and her research group combine anatomical studies of the musculoskeletal system with principles and techniques from engineering to understand the mechanical basis of movement in animals. Current projects include: biomechanics of the temporomandibular joint, muscle architecture, intercostal muscle function, and the development of a new 3D imaging technology, X-ray Reconstruction of Moving Morphology

Link to faculty profile: 
Link to Brainerd laboratory:

People in the Brainerd Lab who use zebrafish as a model system:

Elizabeth Brainerd (PI), Email:
Terry Dial (Graduate Student), Email:
Tom Anzivino (URI summer intern), Email:
Cally Harper* (Graduate Student), Email:

* Prior lab members

The laboratory of Dr. Will Fairbrother
Department of Molecular Biology, Cell Biology, and Biochemistry
Brown University

My lab studies RNA splicing. A third of all hereditary disease mutations affect RNA splicing. Using deep sequencing and array based synthesis, we are measuring the effects of thousands of mutations and SNPs on splicing, spliceosome assembly and RNA protein binding. In the lab there is a strong emphasis on developing hybrid approaches to science, combining genome analysis and computational biology with experimentation.

Link to faculty profile:

People in the Fairbrother Lab who use zebrafish as a model system:

Will Fairbrother (PI), Email:
Chien-Ling Lin (Postdoc), Email:

The laboratory of Dr. Elena Oancea
Department of Molecular Pharmacology, Physiology & Biotechnology
Brown University

The focus of my laboratory is in understanding signal transduction events using fluorescent microscopy in living cells. My lab is equipped with a state-of-the-art two-color TIRF microscope, which we will use to study UV-induced pigmentation in human skin and melanoma behavior. To visualize signal transduction events, we design and generate novel fluorescent probes using molecular biology techniques, which give us a unique angle in answering biologically relevant questions.

Link to faculty profile:

People in the Oancea Lab who use zebrafish as a model system:

Elena Oancea (PI), Email:
Rana (Graduate Student), Email:
Kirk (Graduate Student), Email:
Iliana (Research Assistant), Email:

The Laboratory of Dr. Jason Sello
Department of Chemistry
Brown University

Members of my research group and I have been investigating new approaches to antibacterial therapy and to biofuel production that are inspired by the unique metabolites and physiology of Streptomyces bacteria. A hallmark of my program has been the synergistic application of experimental methods from synthetic organic chemistry, molecular microbiology and biochemistry. Thematically, my research has been organized around potential solutions to challenges in human health and in energy.

Faculty Profile:

People in the Sello Lab who use zebrafish as a model system:

Amanda Dombroski (Graduate Student): 

The laboratory of Dr. Kristi Wharton
Department of Molecular Biology, Cell Biology, and Biochemistry
Brown University

The goal of the research in our laboratory is to understand how TGF-B signaling molecules facilitate the communication between cells. Cellular communication is essential to the proper manifestation of cell movements, growth, and differentiation during the development of multi-cellular organisms.

Link to faculty profile: 

People in the Wharton Lab who use zebrafish as a model system:

Kristi Wharton (PI), Email: 
Cathy Trebino (Research Assistant), Email:
Eric Tung (Undergraduate Student), Email: