The laboratory of Dr. William Fairbrother
Department of Molecular Biology, Cell Biology and Biochemistry
My lab studies RNA splicing. A third of all hereditary disease mutations affect RNA splicing. Using deep sequencing and array based synthesis, we are measuring the effects of thousands of mutations and SNPs on splicing, spliceosome assembly and RNA protein binding. In the lab there is a strong emphasis on developing hybrid approaches to science, combining genome analysis and computational biology with experimentation.
Link to faculty profile: https://vivo.brown.edu/display/wfairbro
People in the Fairbrother Lab who use zebrafish as a model system: