This photo shows the burnt-out sclerotic phase of Paget disease. Woven bone appears as bony shelves divided by cement lines into irregular regions. The earliest phase of the disease was dominated by lysis of bone by osteoclasts. That was followed by a phase during which osteoclastic lysis continued but was dominated by osteoblastic laying down of new bone. Paramyxovirus infection is suspected of playing a role in the causation of Paget disease. There may also be a hereditary component related to a locus on chromosome 18q.
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