Bio-Med Center, 502
University of California,
San Francisco, 1983
Manhattan School of Music
M.A. in Music
New York University, 1973
Elaine Bearer, M.D., Ph.D.
Bio280: Systemic Pathology,
In the Bearer lab, we are interested in cell movements.
We use a combination of video microscopy, cell culture, and molecular biology.
Currently we are focusing on the actin-cytoskeleton to investigate three
types of dynamic cellular behavior:
- Transport of organelles down the axon from the neuronal cell body
to the synaptic terminal requires cytoskeleton. We have identified a novel
transport mechanism--on actin filaments--and are characterizing a unique
myosin motor that powers it.
- Platelet activation. This involves cell-shape changes in which actin
filaments form in response to agonist stimulation. We have identified several
novel proteins that control this shape-change and are studying their individual
- Transformation of the radially symmetric egg into a complex life-form
involves shape-changes and migrations of specific populations of cells.
We are studying the cytoskeletal machinery that permits these cellular
movements. We have found a transcription factor, Xrel-1, that regulates
the expression of proteins responsible for cell movements. We have cloned
this factor and plan to study its function by specifically poisoning it
using dominant negative mutations.
Retrograde axonal transport of Herpes simplex virus. Bearer, et al, Proc. Nat. Acad. Sci.
(in press for publication in July, 2000).
Digital movie sequence.
I am interested in consulting for Biotechnology in molecular biology,
cell culture, hemostasis and am in the process of patenting two of my discoveries.
Bearer, E.L., DeGiorgis, J.A., Medeiros, N.A., Jaffe,
H. and Reese, T.S. (1996) An axoplasmic myosin with a calmodulin-like
light chain. Proc. Nat. Acad. Sci. USA 93: 6064 - 6068.
Bearer, E.L. Cytoskeletal domains in the activated
platelet. Cell Motil. and Cytoskel. 30:50-66, 1995.
Bearer, E.L. (1994) Distribution of Xrel in the early
Xenopus embryo: a cytoplasmic and nuclear gradient. Euro. J. Cell Biol 63: 255 - 268.
Elective clinical clerkship in Guatamala
In addition to the lab work, I am also Director of an Elective Clerkship
for medical students in Guatemala
which is sponsored by the Dept. of Community Health at Brown, although
it is open to students from other Universities.
I am also faculty of the Music Department. To access more information
about my musical compositions (now out on two CDs), please visit my music page.