Dr. Elaine Bearer, Course Leader
Dr. Halit Pinar, Reproductive Pathology Section Leader
502 Biomed Center
x3478

Jan 22 - Feb 12  Gastrointestinal Pathology

Feb 19   Infctious Disease

Feb 24 - Mar 10  Supporting Structure Pathology

  Midterm Exam - Monday, March 16 9:00-12:00 noon
                    Biomed Center Rm. 202

Mar 31 - Apr 14  Endocrine Diseases

Apr 16 - May 5  Reproductive Pathology

    Final Exam, Monday, May 11 9:00-12:00 noon
    Biomed Center Room 202
 

Lectures
Dr. Elaine Bearer  Dept. Pathology, Brown University
Dr. Jack Canick   Dept. Pathology, Women and Infants Hospital
Dr. Katrina Hansen  Dept. Pathology, Women and Infants Hospital
Dr. Eric Hendrickson Div. Biology and Medicine, Brown University
Dr. Abby Hornstein Dept. Pathology, Rhode Island Hospital
Dr. Charles Kuhn  Dept. Pathology, Memorial Hospital of RI
Dr. Ken Miller  Div. Biology and Medicine, Brown University
Dr. Calvin Oyer  Dept. Pathology, Women and Infants Hospital
Dr. Halit Pinar  Dept. Pathology, Women and Infants Hospital
Dr. Leslie Robinson-Bostom, Dept. Pathology, Memorial Hospital of RI
Dr. Margaret Steinhoff Dept. Pathology, Women and Infants Hospital
Dr. James Sung  Dept. Pathology, Women and Infants Hospital

 
 

Gastrointestinal Pathology      10.5 hours
 

Introduction (10 minutes)       Dr. Bearer

Thur - Jan 22  Esophagus      Dr. Pinar
pp 755-783   (70 minutes)

Tues - Jan 27  Diseases of the Small Intestine  Dr. Pinar
pp 783-825   and Colon (80 minutes)

Thur - Jan 29  Pancreas & Biliary System   Dr. Hansen
pp 831-842   Liver: structure/function   Dr. Miller
    (40 minutes)
 
Tues-Feb 3   Diseases of the Liver 1   Dr. Hansen
pp 842-883   (80 minutes)

Thur - Feb 5   Diseases of the Liver 2   Dr. Hansen
pp 883-907   (80 minutes)
 

Tues - Feb 10  Diabetes     Dr. Bearer
pp 907-923   (40 minutes)

Tues - Feb 10  Human Diseases Genes      Dr. Hendrickson
     (40 minutes)

Thur - Feb 12  Review/Case Discussion   Dr. Bearer

Infectious Diseases        1.5 hours

Thur - Feb 19  Viral diseases    Dr. Pinar
pp 313-314   (40 minutes)
322-328
330-358   Fungal Diseases    Dr. Oyer
442-444   (40 minutes)
 

Supporting Structures Pathology      7.5 hours

Tues - Feb 24   Diseases of Skin    Dr. Robinson-Bostom
pp 1173-1209    Malignancies
      Dermatoses
       (80 minutes)

Thurs - Feb 26  Diseases of Bone and Muscle  Dr. Hornstein
pp 1213-1246   (80 minutes)
     1261-1269
 

Tues - Mar 3   Systemic Pathology of Connective Dr. Bearer
pp 199-215   Tissue Diseases
    Autoimmune Diseases: Systemic Lupus
          Erythematosus, Scleroderma, Sjögren's
    Syndrome and Mixed Connective Tissue
     Diseases (80 minutes)

Thurs - Mar 5  Systemic Pathology of Connective Dr. Bearer
pp 1246-1261  Tissue Diseases: (cont)
        Rheumatoid Arthritis (40 minutes)

Tues - Mar 10  Review/Case Discussion   Dr. Bearer
 

Endocrine Pathology      7.5 hours

Tues - Mar 31  Neuroendocrine System and Pituitary Drs. Canick & Pinar
pp  555-556   (80 minutes)
      818-820
     922-924
     1113-1121
     1165;1169-1170

Thur - Apr 2    Thyroid and Parathyroid   Drs.Canick & Pinar    pp 1121-1148   Diseases
     (80 minutes)

Tues - Apr 7  Diseases of the Adrenal Cortex  Dr. Pinar
pp 1148-1165 and Medulla
   (80 minutes)

Thurs - Apr 9 Male Genital Tract: Testis,   Dr. Boekelheide
pp  1007-1032 Epididymis and Prostate
   (80 minutes)

Tues - Apr 14 Review/Case Discussion   Dr. Bearer
   (80 minutes)
 

Human Growth and Development, Dr. Pinar Section Leader 7.5 hours

Thurs - April 16         Female Genital Tract: Vulva Vagina,  Dr. Sung
pp 1039-64  Cervix, Uterus & Tubes
   (80 minutes)
 
Tues - Apr 21 Ovary      Dr. Steinhoff
pp 1156-1178 (80 minutes)
 1054-1055
 1064-1077
 
Thurs - Apr 23 Embryology and Placental Anatomy  Dr. Pinar
pp 1082-1084 (80 minutes)

Tues - Apr 28 Abnormal Human Development;   Dr. Oyer
pp 154-162  and Chromosomal Abnormalities
 437-442  (80 minutes)
 671-675
 756-757
 769-770
 930-938
 992
 1011-1013
 1217-1219
 1300-1303
 

Thurs - Apr 30 Childhood Neoplasia     Dr. Oyer
 pp 456-465  (80 minutes)
     879, 1244,
     1267-1268
     1342-1343
     1346-1347
     1353-1354
 
Tues - May 5 Review/Case Discussion    Dr. Bearer
   (80 minutes)
 

Systemic Pathology 280
Objectives

This course will help you to gain more expertise in two of Brown's Nine Abilities:

 1) Using basic science in the practice of medicine
 2)  Lifelong learning
 
You will be expected to read the assigned pages in the Robbins Pathologic Basis of Disease, attend the lectures, and read the journal articles on reserve in the Science Library.  You must use this information to perform the following tasks:
 1) Understand the clinical presentations of the most common diseases
 2) Be able to describe the morphological features of organs effected by the
       disease
 3) Understand the underlying mechanism of injury (the pathogenesis)
 4) Apply the knowledge of pathogenesis of disease to a specific person
      presenting with an illness

There will be two exams which are not cumulative--you must past both exams to pass this course.  The exams will contain some multiple choice questions taken from old Medical Board Part I exams, and short answer and essay questions based on the course material and the cases.

Grades:

You can all achieve the basic goals of this course by fulfilling the following plan of action:

1.  Read the textbook : concentrate on the diseases discussed in lecture and try to design your own tables to categorize the pathologic changes and to compare similar but different entities;

2.  Attend the lectures: Be sure that you have understood the major points at the end of class.  Don't be afraid to ask questions, or to come and see me during office hours.

3.  Review your lecture notes and assigned reading systematically before each exam.
 
 

Honors will be awarded based on achieving a cumulative exam score above 90%.

You have all successfully completed two semesters of Pathology and you know the basis of many human diseases.  If you use that knowledge, attend lectures, and study the text, you should all pass this course and the National Boards successfully!

List of additional readings on reserve in the SciLi:

Good color photographs of Gross pathology specimens

Sandritter, W. Thomas, C., and Kirsten, W.H., Color Atlas of Macropathology
     Gross pathology with short descriptive texts and tables

Reith, E.J. and Ross, M.H., Atlas of Descriptive Histology Normal histology and EM

Leeson, T.S. and Leeson, C.R., A brief Atlas of Histology Normal histology, some text

Moore, R.L. and Persand, T.V.N. The Developing Human