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A cartoon of a single-peaked
fitness function, the expected time to the optimum on which is nevertheless
equal to that on any random multipeaked fitness function. Click image for details.
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Current
Members
Daniel M.
Weinreich, Ph.D.
Jennifer
Knies, Ph.D.
Brendan
Hickey, Sc.B. 08
Rachel
Cohn, 10
Michaeline Nelson, 11
Stephanie
Spielman, 10
Robin
Zelman, 09
Alumni
Alexander
Franks, 08
Jacob
Johnson, 08
Nicholas
Haldan,08
Rohan Maddamestti,
08
Glen Scheinberg, 08
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Our group uses computers,
mathematics and a diversity of microbes to ask basic questions about
evolutionary genetics. Click on lab
members names above for details on individual projects.
We are actively recruiting new
members at all levels from high school to post-doctoral. Please send an email to Dan Weinreich describing your
background and interest if you would like to join us.
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A portion of the crystal
structure of the TEM-1 β-lactamase.
We have examined the effect on drug resistance of all combinations
of the four mutations shown. Click
image for details.
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The procession of fixed points
in pA
Χ D-space as a function of
recombination rate (r) for a
two-peaked fitness function. Yellow
represents the biologically meaningful region; note that for some r > 0, the red points lie within
this region. In this case they are
saddles defining the boundary between basins of attraction. (The same is true for the purple points
when r < 0, though this only a mathematical curiosity.)
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