Brown University Center for Computational Molecular Biology

News Archive

Sorin Istrail Awarded Title of Professor Honoris Causa from Alexandru Ioan Cuza University
Aug 17, 2010
Aug 17, 2010
Alexandru Ioan Cuza University, Iasi, Romania

As part of the celebration of its 150th anniversary, Alexandru Ioan Cuza University in Iasi, Romania, presented an honorary professorship (Professor Honoris Causa) to alumnus Sorin Istrail. Read more by clicking here!

Postdoctoral Fellow Fabio Vandin and PhD candidate Derek Aguiar win Travel Awards for the RECOMB 2010
August 2010
August 2010
Lisbon, Portugal

Postdoctoral Fellow Fabio Vandin and PhD candidate Derek Aguiar win Travel Awards for the RECOMB 2010 where they presented their papers. The Annual International Conference on Research in Computational Biology -- RECOMB -- is one of the top conferences in computational biology.

Bjarni V. Halldo´rsson, Derek Aguiar, Ryan Tarpine, and Sorin Istrail. The Clark Phaseable Sample Size Problem: Long-Range Phasing and Loss of Heterozygosity in GWAS. Journal of Computational Biology, 18(3):323–333, March 2011.

Fabio Vandin, Eli Upfal, and Benjamin J. Raphael. Algorithms for detecting significantly mutated pathways in cancer. Journal of Computational Biology, 18(3):507–522, March 2011.

May 2010 CCMB Symposium Videos in HD
May 2010
May 2010
Brown University

May 2010 Symposium lectures and Q&A sessions posted online in HD!
View the schedule of the talks and streaming video.

Ryan Tarpine and Sorin Istrail featured in Today at Brown's article entitled "A ‘great leap forward’ in gene research".
March 24, 2010
March 24, 2010
Department of Computer Science, Brown University

Grad student Ryan Tarpine has created a software program that will help scientists reach a better – and faster – understanding – of why species evolved differently over time. Read more here.

RECOMB Satellite Conference
on SNPs and Haplotypes - January 27-28, 2007
January 27-28, 2007
University of Southern California

Organized by the
Department of Molecular and Computational Biology,
University of Southern California
in collaborations with
the Center for Computational Molecular Biology, Brown University
University of Southern California, Los Angeles

Genome Magazine highlights Ben Raphael's Work
January 3, 2007

Genome Technology Magazine Recognizes Ben Raphael as Rising Star

The January 2007 issue of Genome Technology magazine named Center for Computational Molecular Biology Assistant Professor Ben Raphael to their annual "Tomorrow's PIs" list.

Raphael received his Ph.D. from the University of California, San Diego in 2002 and joined the Brown faculty in September. In the past year Raphael and his colleagues published a paper in Genome Research titled, "Decoding the fine-scale structure of a breast cancer genome and transcriptome." The study demonstrated advantages of end sequence profiling to map the rearrangements of tumor genomes using the MCF-7 breast cancer cell line; those include the ability to generate tumor-specific reagents for in vitro and in vivo studies as well as detection of rearrangement and copy number changes...

Article at Brown CS

Center Research featured in Proceedings of
The National Academy of Sciences (Ben Raphael)
December 20, 2006

Evolution, Software, and Microinversions

Biologists will be able to reconstruct the process of evolution, determine relationships between species and build phylogenetic trees with greater accuracy thanks to a new method for identifying “microinversions,” which are extremely short strings of inverted nucleotides. This new work from researchers at UC San Diego and Brown University appeared in the online edition of the Proceedings of the National Academy of Sciences (PNAS)...

Article at Brown CS

Sea Urchin Genome Is
a Biology Boon and a Computational Feat (Sorin Istrail)
November 9, 2006

Now that the entire DNA map of the sea urchin is complete, it's clear that these spiny sea creatures are even closer genetic cousins to humans than suspected. Brown University professors Gary Wessel and Sorin Istrail helped reveal the secrets of the urchin - from its powerful immune system to its formidable gene regulatory network - by identifying individual genes and creating the first high-resolution map of genes activated in its embryo. The work appears on the cover of Science...

*The Transcriptome of the Sea Urchin Embryo

*The Genome of the Sea Urchin Strongylocentrotus purpuratus

Inaugural Distinguished Lectures
Poster, 2006

~Inaugural Distinguished Lectures 2005-2006
~Coming Inaugural Distinguished Lectures in 2006-2007

Ben Raphael joins CCMB
September 1, 2006

Raphael joins the CCMB after completing a postdoctoral fellowship at the University of California, San Diego. Prof. Raphael research interests include computational cancer biology and the design and application of algorithms for problems in comparative genomics, regulatory genomics, and genetic variation. He holds a Career Award at the Scientific Interface from the Burroughs Wellcome Fund, and was the recipient of Alfred P. Sloan Postdoctoral Fellowship in Computational Molecular Biology.

Paradigm Shift in RNA Inference
June 2006

The "power of sampling" RNA secondary structure pioneered by Professor Lawrence and colleagues is highlighted in a recent review article in the Journal of Molecular Biology (J. Mol. Biol. (2006) 359, 526-532). "Recent results show the power of sampling in predicting regions in an RNA that are most likely to be accessible to hybridization, in predicting secondary structures with fewer false positive base-pairs, and to understanding the folding landscape. The impact of this is enormous because, for the first time, the set of predicted secondary structures is a statistical sample of the complete ensemble of structures. The probability of sampling any given structure is exactly its probability of occurring in the thermodynamic ensemble".

Brown Students present Computational Biology Research
May, 2006

Student Poster Day on Computational Biology
hosted by
Professor Will Fairbrother

The First Annual Computational Biology Poster Session was held in Room 105 of the Center for Genomics and Proteomics on Friday, May 5th, 2006, from 3:00-5:00pm. Posters ranged from image processing, to simulation of protein nucleic acid recognition events, to the development of special alignment tools for non-coding regulatory elements. It was a great opportunity to meet students and faculty interested in Computational Biology here at Brown...

Brown Computational Biology Initiative
September, 2003

Endowed by a $20 million gift from a Brown trustee

The Center for Computational Molecular Biology (CCMB) at Brown was founded in September 2003 with the aim of establishing a world-class center for research and scholarship in this new discipline.

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